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Differential Vascularity in Genetic and Nonhereditary Heterotopic Ossification.
Int J Surg Pathol. 2019 Dec; 27(8):859-867.IJ

Abstract

Introduction.

Nonhereditary heterotopic ossification (NHO) is a common complication of trauma. Progressive osseous heteroplasia (POH) and fibrodysplasia ossificans progressiva (FOP) are rare genetic causes of heterotopic bone. In this article, we detail the vascular patterning associated with genetic versus NHO. Methods. Vascular histomorphometric analysis was performed on patient samples from POH, FOP, and NHO. Endpoints for analysis included blood vessel (BV) number, area, density, size, and wall thickness.

Results.

Results demonstrated conserved temporal dynamic changes in vascularity across all heterotopic ossification lesions. Immature areas had the highest BV number, while the more mature foci had the highest BV area. Most vascular parameters were significantly increased in genetic as compared with NHO. Discussion. In sum, both genetic and NHO show temporospatial variation in vascularity. These findings suggest that angiogenic pathways are potential therapeutic targets in both genetic and nonhereditary forms of heterotopic ossification.

Authors+Show Affiliations

Johns Hopkins University, Baltimore, MD, USA.University of Pennsylvania, Philadelphia, PA, USA.Johns Hopkins University, Baltimore, MD, USA.Johns Hopkins University, Baltimore, MD, USA.Johns Hopkins University, Baltimore, MD, USA.University of Pennsylvania, Philadelphia, PA, USA.Johns Hopkins University, Baltimore, MD, USA.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

31250694

Citation

Ware, Alisha D., et al. "Differential Vascularity in Genetic and Nonhereditary Heterotopic Ossification." International Journal of Surgical Pathology, vol. 27, no. 8, 2019, pp. 859-867.
Ware AD, Brewer N, Meyers C, et al. Differential Vascularity in Genetic and Nonhereditary Heterotopic Ossification. Int J Surg Pathol. 2019;27(8):859-867.
Ware, A. D., Brewer, N., Meyers, C., Morris, C., McCarthy, E., Shore, E. M., & James, A. W. (2019). Differential Vascularity in Genetic and Nonhereditary Heterotopic Ossification. International Journal of Surgical Pathology, 27(8), 859-867. https://doi.org/10.1177/1066896919857135
Ware AD, et al. Differential Vascularity in Genetic and Nonhereditary Heterotopic Ossification. Int J Surg Pathol. 2019;27(8):859-867. PubMed PMID: 31250694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential Vascularity in Genetic and Nonhereditary Heterotopic Ossification. AU - Ware,Alisha D, AU - Brewer,Niambi, AU - Meyers,Carolyn, AU - Morris,Carol, AU - McCarthy,Edward, AU - Shore,Eileen M, AU - James,Aaron W, Y1 - 2019/06/28/ PY - 2019/6/30/pubmed PY - 2020/6/20/medline PY - 2019/6/29/entrez KW - angiogenesis KW - fibrodysplasia ossificans progressive KW - heterotopic bone KW - heterotopic ossification KW - progressive heterotopic ossification SP - 859 EP - 867 JF - International journal of surgical pathology JO - Int. J. Surg. Pathol. VL - 27 IS - 8 N2 - Introduction. Nonhereditary heterotopic ossification (NHO) is a common complication of trauma. Progressive osseous heteroplasia (POH) and fibrodysplasia ossificans progressiva (FOP) are rare genetic causes of heterotopic bone. In this article, we detail the vascular patterning associated with genetic versus NHO. Methods. Vascular histomorphometric analysis was performed on patient samples from POH, FOP, and NHO. Endpoints for analysis included blood vessel (BV) number, area, density, size, and wall thickness. Results. Results demonstrated conserved temporal dynamic changes in vascularity across all heterotopic ossification lesions. Immature areas had the highest BV number, while the more mature foci had the highest BV area. Most vascular parameters were significantly increased in genetic as compared with NHO. Discussion. In sum, both genetic and NHO show temporospatial variation in vascularity. These findings suggest that angiogenic pathways are potential therapeutic targets in both genetic and nonhereditary forms of heterotopic ossification. SN - 1940-2465 UR - https://www.unboundmedicine.com/medline/citation/31250694/Differential_Vascularity_in_Genetic_and_Nonhereditary_Heterotopic_Ossification_ L2 - http://journals.sagepub.com/doi/full/10.1177/1066896919857135?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -