Tags

Type your tag names separated by a space and hit enter

Baloxavir marboxil: a novel cap-dependent endonuclease (CEN) inhibitor for the treatment of acute uncomplicated influenza.
Drugs Today (Barc). 2019 Jun; 55(6):359-366.DT

Abstract

Baloxavir marboxil is a newly approved antiviral agent with activity against influenza via a novel mechanism of action of inhibition of cap-dependent endonuclease (CEN). The novel agent was approved in October of 2018 in the United States for the treatment of acute uncomplicated influenza A and B in patients aged 12 years or older. Baloxavir is given as a single weight-based dose of 40 mg orally once for patients weighing less than 80 kg and 80 mg orally once for those weighing 80 kg or more within 48 hours of symptom onset. In comparison with current therapy, baloxavir is as effective in decreasing time to symptom alleviation as the drug of choice, oseltamivir, and significantly reduces viral load 1 day after treatment compared with placebo and oseltamivir. In safety analyses baloxavir was well tolerated with only mild adverse events reported (nausea, headache, diarrhea, bronchitis, nasopharyngitis), thus providing a safe and reliable alternative option to current therapy for acute uncomplicated influenza. Further studies are being conducted to evaluate the use of baloxavir in additional patient populations including pediatric patients less than 12 years of age and patients who are at high risk of complications related to influenza.

Authors+Show Affiliations

The University of Texas at Tyler, College of Pharmacy, Tyler, Texas, USA.The University of Texas at Tyler, College of Pharmacy, Tyler, Texas, USA.The University of Texas at Tyler, College of Pharmacy, Tyler, Texas, USA. jcho@uttyler.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31250840

Citation

Locke, S C., et al. "Baloxavir Marboxil: a Novel Cap-dependent Endonuclease (CEN) Inhibitor for the Treatment of Acute Uncomplicated Influenza." Drugs of Today (Barcelona, Spain : 1998), vol. 55, no. 6, 2019, pp. 359-366.
Locke SC, Splawn LM, Cho JC. Baloxavir marboxil: a novel cap-dependent endonuclease (CEN) inhibitor for the treatment of acute uncomplicated influenza. Drugs Today (Barc). 2019;55(6):359-366.
Locke, S. C., Splawn, L. M., & Cho, J. C. (2019). Baloxavir marboxil: a novel cap-dependent endonuclease (CEN) inhibitor for the treatment of acute uncomplicated influenza. Drugs of Today (Barcelona, Spain : 1998), 55(6), 359-366. https://doi.org/10.1358/dot.2019.55.6.2999889
Locke SC, Splawn LM, Cho JC. Baloxavir Marboxil: a Novel Cap-dependent Endonuclease (CEN) Inhibitor for the Treatment of Acute Uncomplicated Influenza. Drugs Today (Barc). 2019;55(6):359-366. PubMed PMID: 31250840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baloxavir marboxil: a novel cap-dependent endonuclease (CEN) inhibitor for the treatment of acute uncomplicated influenza. AU - Locke,S C, AU - Splawn,L M, AU - Cho,J C, PY - 2019/6/29/entrez PY - 2019/6/30/pubmed PY - 2019/8/6/medline KW - Anti-influenza virus drugs KW - Antiviral drugs KW - Baloxavir marboxil KW - Capdependent endonuclease (CEN) inhibitors KW - Influenza A and B virus infection SP - 359 EP - 366 JF - Drugs of today (Barcelona, Spain : 1998) JO - Drugs Today (Barc) VL - 55 IS - 6 N2 - Baloxavir marboxil is a newly approved antiviral agent with activity against influenza via a novel mechanism of action of inhibition of cap-dependent endonuclease (CEN). The novel agent was approved in October of 2018 in the United States for the treatment of acute uncomplicated influenza A and B in patients aged 12 years or older. Baloxavir is given as a single weight-based dose of 40 mg orally once for patients weighing less than 80 kg and 80 mg orally once for those weighing 80 kg or more within 48 hours of symptom onset. In comparison with current therapy, baloxavir is as effective in decreasing time to symptom alleviation as the drug of choice, oseltamivir, and significantly reduces viral load 1 day after treatment compared with placebo and oseltamivir. In safety analyses baloxavir was well tolerated with only mild adverse events reported (nausea, headache, diarrhea, bronchitis, nasopharyngitis), thus providing a safe and reliable alternative option to current therapy for acute uncomplicated influenza. Further studies are being conducted to evaluate the use of baloxavir in additional patient populations including pediatric patients less than 12 years of age and patients who are at high risk of complications related to influenza. SN - 1699-3993 UR - https://www.unboundmedicine.com/medline/citation/31250840/Baloxavir_marboxil:_a_novel_cap_dependent_endonuclease__CEN__inhibitor_for_the_treatment_of_acute_uncomplicated_influenza_ L2 - http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=4&p_RefId=2999889 DB - PRIME DP - Unbound Medicine ER -