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Arbutin reduces cognitive deficit and oxidative stress in animal model of Alzheimer's disease.
Int J Neurosci. 2019 Nov; 129(11):1145-1153.IJ

Abstract

Objectives:

Recent evidences have shown the beneficial effects of natural products for treating of Alzheimer's disease (AD). Arbutin is derived from Pyrus biossieriana and exerts a wide range of pharmacological activities including anti-inflammatory and anti-oxidant effects. The present study was designed to examine the protective effects of arbutin on streptozotocin (STZ)-induced neurotoxicity in rats. Materials and methods: The spatial memory impairment was induced by intracerebroventricular (i.c.v) microinjection of STZ (3 mg/kg, 10 μL). Animals received the pretreatment of arbutin (50 mg/kg) for 21 days before STZ injection. The Morris Water maze (MWM) task was used to study the spatial learning and memory. The levels of oxidative stress markers including malondialdehyde (MDA), nitrite and carbonyl were measured in serum and hippocampus samples. In addition, antioxidant level was assessed by ferric reducing antioxidant power (FRAP) test.

Results:

The obtained result indicated that administration of STZ is led to memory impairment and increases the levels of oxidative stress markers in the hippocampus tissues. Conversely, arbutin improves spatial memory and reduces oxidative and nitrosative stress, as evidenced by a significant decrease in the amount of MDA and nitrite in the serum and hippocampus. In addition, an increase in FRAP levels of hippocampus was observed in arbutin receiving animals. The protein carbonyl content was not reduced in arbutin receiving animals.

Conclusion:

It could be concluded that arbutin protects the brain against STZ-induced memory impairment and oxidative damage in the hippocampus. The neuroprotective effect of arbutin might be mediated through its antioxidant and free radical scavenging effects.

Authors+Show Affiliations

Student Research Committee, Babol University of Medical Sciences , Babol , Iran. Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences , Babol , Iran.Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences , Babol , Iran. Cellular and Molecular Biology Research Centre, Health Research Institute, Babol University of Medical Sciences , Babol , Iran.Cellular and Molecular Biology Research Centre, Health Research Institute, Babol University of Medical Sciences , Babol , Iran.Department of Animal Biology, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran , Tehran , Iran.Student Research Committee, Babol University of Medical Sciences , Babol , Iran. Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences , Babol , Iran.Department of Anatomy, Faculty of Medicine, Babol University of Medical Sciences , Babol , Iran.Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences , Babol , Iran.Cellular and Molecular Biology Research Centre, Health Research Institute, Babol University of Medical Sciences , Babol , Iran. Department of Anatomy, Faculty of Medicine, Babol University of Medical Sciences , Babol , Iran.Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences , Babol , Iran. Department of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences , Babol , Iran.Department of Epidemiology, Faculty of Medicine, Babol University of Medical Sciences , Babol , Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31251091

Citation

Dastan, Zohreh, et al. "Arbutin Reduces Cognitive Deficit and Oxidative Stress in Animal Model of Alzheimer's Disease." The International Journal of Neuroscience, vol. 129, no. 11, 2019, pp. 1145-1153.
Dastan Z, Pouramir M, Ghasemi-Kasman M, et al. Arbutin reduces cognitive deficit and oxidative stress in animal model of Alzheimer's disease. Int J Neurosci. 2019;129(11):1145-1153.
Dastan, Z., Pouramir, M., Ghasemi-Kasman, M., Ghasemzadeh, Z., Dadgar, M., Gol, M., Ashrafpour, M., Pourghasem, M., Moghadamnia, A. A., & Khafri, S. (2019). Arbutin reduces cognitive deficit and oxidative stress in animal model of Alzheimer's disease. The International Journal of Neuroscience, 129(11), 1145-1153. https://doi.org/10.1080/00207454.2019.1638376
Dastan Z, et al. Arbutin Reduces Cognitive Deficit and Oxidative Stress in Animal Model of Alzheimer's Disease. Int J Neurosci. 2019;129(11):1145-1153. PubMed PMID: 31251091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Arbutin reduces cognitive deficit and oxidative stress in animal model of Alzheimer's disease. AU - Dastan,Zohreh, AU - Pouramir,Mahdi, AU - Ghasemi-Kasman,Maryam, AU - Ghasemzadeh,Zahra, AU - Dadgar,Masoumeh, AU - Gol,Mohammad, AU - Ashrafpour,Manouchehr, AU - Pourghasem,Mohsen, AU - Moghadamnia,Ali Akbar, AU - Khafri,Soraya, Y1 - 2019/07/19/ PY - 2019/6/30/pubmed PY - 2020/2/14/medline PY - 2019/6/29/entrez KW - Arbutin KW - oxidative stress KW - spatial memory impairment KW - streptozotocin SP - 1145 EP - 1153 JF - The International journal of neuroscience JO - Int J Neurosci VL - 129 IS - 11 N2 - Objectives: Recent evidences have shown the beneficial effects of natural products for treating of Alzheimer's disease (AD). Arbutin is derived from Pyrus biossieriana and exerts a wide range of pharmacological activities including anti-inflammatory and anti-oxidant effects. The present study was designed to examine the protective effects of arbutin on streptozotocin (STZ)-induced neurotoxicity in rats. Materials and methods: The spatial memory impairment was induced by intracerebroventricular (i.c.v) microinjection of STZ (3 mg/kg, 10 μL). Animals received the pretreatment of arbutin (50 mg/kg) for 21 days before STZ injection. The Morris Water maze (MWM) task was used to study the spatial learning and memory. The levels of oxidative stress markers including malondialdehyde (MDA), nitrite and carbonyl were measured in serum and hippocampus samples. In addition, antioxidant level was assessed by ferric reducing antioxidant power (FRAP) test. Results: The obtained result indicated that administration of STZ is led to memory impairment and increases the levels of oxidative stress markers in the hippocampus tissues. Conversely, arbutin improves spatial memory and reduces oxidative and nitrosative stress, as evidenced by a significant decrease in the amount of MDA and nitrite in the serum and hippocampus. In addition, an increase in FRAP levels of hippocampus was observed in arbutin receiving animals. The protein carbonyl content was not reduced in arbutin receiving animals. Conclusion: It could be concluded that arbutin protects the brain against STZ-induced memory impairment and oxidative damage in the hippocampus. The neuroprotective effect of arbutin might be mediated through its antioxidant and free radical scavenging effects. SN - 1563-5279 UR - https://www.unboundmedicine.com/medline/citation/31251091/Arbutin_reduces_cognitive_deficit_and_oxidative_stress_in_animal_model_of_Alzheimer's_disease_ L2 - https://www.tandfonline.com/doi/full/10.1080/00207454.2019.1638376 DB - PRIME DP - Unbound Medicine ER -