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A new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms.
J Pharm Biomed Anal 2019; 174:534-540JP

Abstract

A novel sensor based on a modification of glassy carbon electrode (GCE) with NH2-functionalized multi-walled carbon nano-tubes (NH2fMWCNTs) is reported and its applicability to the electrochemical sensing of Propafenone (PPF) demonstrated. The electrochemical catalytic activity was also utilized as a sensitive detection method for the investigation of the detailed redox mechanism of PFF using cyclic and and differential pulse voltammetry. The surface morphology of the sensor was investigated by SEM armed with EDX probe. Electrochemical impedance spectroscopy was employed as well to define the electron transfer capability of modified and bare electrodes. Key experimental and instrumental conditions related to electrochemical determination by cyclic, differential pulse, and square wave voltammetry, such as amount of modifier, pH, scan rate, accumulation time and potential were studied and optimized. The results have shown a significant enhancement of the peak current after modifying the electrode; the calibration curves of PPF offering good linearity from 0.1 to 10 μM, limit of quantification (LOQ) being 0.03 μM and limit of detection (LOD) 0.01 μM, both when using DPV technique. The proposed sensor was successfully applied to the determination of PFF in dosage form without any special purification, separation or pre-treatment steps. The results of analyses obtained with the proposed sensor were satisfactory and fully statistically relevant.

Authors+Show Affiliations

Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560, Ankara, Turkey; Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10, Pardubice, Czech Republic.Hitit University, Faculty of Art & Science, Department of Chemistry, Corum, Turkey.Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10, Pardubice, Czech Republic.Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560, Ankara, Turkey. Electronic address: ozkan@pharmacy.ankara.edu.tr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31252310

Citation

Farag, Amir S., et al. "A New Sensing Platform Based On NH2fMWCNTs for the Determination of Antiarrhythmic Drug Propafenone in Pharmaceutical Dosage Forms." Journal of Pharmaceutical and Biomedical Analysis, vol. 174, 2019, pp. 534-540.
Farag AS, Bakirhan NK, Švancara I, et al. A new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms. J Pharm Biomed Anal. 2019;174:534-540.
Farag, A. S., Bakirhan, N. K., Švancara, I., & Ozkan, S. A. (2019). A new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms. Journal of Pharmaceutical and Biomedical Analysis, 174, pp. 534-540. doi:10.1016/j.jpba.2019.06.026.
Farag AS, et al. A New Sensing Platform Based On NH2fMWCNTs for the Determination of Antiarrhythmic Drug Propafenone in Pharmaceutical Dosage Forms. J Pharm Biomed Anal. 2019 Sep 10;174:534-540. PubMed PMID: 31252310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms. AU - Farag,Amir S, AU - Bakirhan,Nurgul K, AU - Švancara,Ivan, AU - Ozkan,Sibel A, Y1 - 2019/06/20/ PY - 2019/04/29/received PY - 2019/05/29/revised PY - 2019/06/19/accepted PY - 2019/6/30/pubmed PY - 2019/6/30/medline PY - 2019/6/29/entrez KW - Drug analysis KW - Electrochemistry KW - Glassy carbon electrode KW - Nanotubes KW - Propafenone SP - 534 EP - 540 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 174 N2 - A novel sensor based on a modification of glassy carbon electrode (GCE) with NH2-functionalized multi-walled carbon nano-tubes (NH2fMWCNTs) is reported and its applicability to the electrochemical sensing of Propafenone (PPF) demonstrated. The electrochemical catalytic activity was also utilized as a sensitive detection method for the investigation of the detailed redox mechanism of PFF using cyclic and and differential pulse voltammetry. The surface morphology of the sensor was investigated by SEM armed with EDX probe. Electrochemical impedance spectroscopy was employed as well to define the electron transfer capability of modified and bare electrodes. Key experimental and instrumental conditions related to electrochemical determination by cyclic, differential pulse, and square wave voltammetry, such as amount of modifier, pH, scan rate, accumulation time and potential were studied and optimized. The results have shown a significant enhancement of the peak current after modifying the electrode; the calibration curves of PPF offering good linearity from 0.1 to 10 μM, limit of quantification (LOQ) being 0.03 μM and limit of detection (LOD) 0.01 μM, both when using DPV technique. The proposed sensor was successfully applied to the determination of PFF in dosage form without any special purification, separation or pre-treatment steps. The results of analyses obtained with the proposed sensor were satisfactory and fully statistically relevant. SN - 1873-264X UR - https://www.unboundmedicine.com/medline/citation/31252310/A_new_sensing_platform_based_on_NH2fMWCNTs_for_the_determination_of_antiarrhythmic_drug_Propafenone_in_pharmaceutical_dosage_forms L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(19)31065-9 DB - PRIME DP - Unbound Medicine ER -