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The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, mean arterial blood pressure and heart rate in adult male rats.
Lab Anim Sci. 1987 Dec; 37(6):736-42.LA

Abstract

Although anesthetics are known to cause respiratory and cardiovascular depression in humans, these adverse effects rarely have been investigated in laboratory rodents. This study evaluated the effects of four different injectable drugs, pentobarbital, fentanyl-droperidol (Innovar-Vet), ketamine-xylazine and ketamine-diazepam on the respiratory and cardiovascular systems of rats. Results showed marked acidosis, hypercarbia and hypoxia with high doses of Innovar-Vet, moderate respiratory depression with all dosages of pentobarbital and minimal respiratory depression with ketamine-xylazine and ketamine-diazepam. Innovar-Vet, ketamine-xylazine and pentobarbital caused profound hypotension, particularly at high dosages, while ketamine-diazepam caused the least depression in mean arterial blood pressure of all drugs evaluated. None of the drugs studied produced significant alterations in heart rate. Throughout all dosages investigated, the ketamine-diazepam combination showed the least overall effects on ventilation and perfusion of the four parenteral drug combinations studied.

Authors+Show Affiliations

Department of Comparative Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3125387

Citation

Wixson, S K., et al. "The Effects of Pentobarbital, Fentanyl-droperidol, Ketamine-xylazine and Ketamine-diazepam On Arterial Blood pH, Blood Gases, Mean Arterial Blood Pressure and Heart Rate in Adult Male Rats." Laboratory Animal Science, vol. 37, no. 6, 1987, pp. 736-42.
Wixson SK, White WJ, Hughes HC, et al. The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, mean arterial blood pressure and heart rate in adult male rats. Lab Anim Sci. 1987;37(6):736-42.
Wixson, S. K., White, W. J., Hughes, H. C., Lang, C. M., & Marshall, W. K. (1987). The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, mean arterial blood pressure and heart rate in adult male rats. Laboratory Animal Science, 37(6), 736-42.
Wixson SK, et al. The Effects of Pentobarbital, Fentanyl-droperidol, Ketamine-xylazine and Ketamine-diazepam On Arterial Blood pH, Blood Gases, Mean Arterial Blood Pressure and Heart Rate in Adult Male Rats. Lab Anim Sci. 1987;37(6):736-42. PubMed PMID: 3125387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, mean arterial blood pressure and heart rate in adult male rats. AU - Wixson,S K, AU - White,W J, AU - Hughes,H C,Jr AU - Lang,C M, AU - Marshall,W K, PY - 1987/12/1/pubmed PY - 2001/3/28/medline PY - 1987/12/1/entrez SP - 736 EP - 42 JF - Laboratory animal science JO - Lab Anim Sci VL - 37 IS - 6 N2 - Although anesthetics are known to cause respiratory and cardiovascular depression in humans, these adverse effects rarely have been investigated in laboratory rodents. This study evaluated the effects of four different injectable drugs, pentobarbital, fentanyl-droperidol (Innovar-Vet), ketamine-xylazine and ketamine-diazepam on the respiratory and cardiovascular systems of rats. Results showed marked acidosis, hypercarbia and hypoxia with high doses of Innovar-Vet, moderate respiratory depression with all dosages of pentobarbital and minimal respiratory depression with ketamine-xylazine and ketamine-diazepam. Innovar-Vet, ketamine-xylazine and pentobarbital caused profound hypotension, particularly at high dosages, while ketamine-diazepam caused the least depression in mean arterial blood pressure of all drugs evaluated. None of the drugs studied produced significant alterations in heart rate. Throughout all dosages investigated, the ketamine-diazepam combination showed the least overall effects on ventilation and perfusion of the four parenteral drug combinations studied. SN - 0023-6764 UR - https://www.unboundmedicine.com/medline/citation/3125387/The_effects_of_pentobarbital_fentanyl_droperidol_ketamine_xylazine_and_ketamine_diazepam_on_arterial_blood_pH_blood_gases_mean_arterial_blood_pressure_and_heart_rate_in_adult_male_rats_ DB - PRIME DP - Unbound Medicine ER -