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Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice.
Biochem Pharmacol 2019; 168:119-132BP

Abstract

Fibromyalgia is a disease characterised as generalised chronic primary pain that causes functional disability and a reduction in patients' quality of life, without specific pathophysiology or appropriate treatment. Previous studies have shown that kinins and their B1 and B2 receptors contribute to chronic painful conditions. Thus, we investigated the involvement of kinins and their B1 and B2 receptors in a fibromyalgia-like pain model induced by reserpine in mice. Nociceptive parameters (mechanical allodynia, cold sensitivity and overt nociception) and behaviours of burrowing, thigmotaxis, and forced swimming were evaluated after reserpine administration in mice. The role of kinin B1 and B2 receptors was investigated using knockout mice or pharmacological antagonism. The protein expression of kinin B1 and B2 receptors and the levels of bradykinin and monoamines were measured in the sciatic nerve, spinal cord and cerebral cortex of the animals. Knockout mice for the kinin B1 and B2 receptor reduced reserpine-induced mechanical allodynia. Antagonism of B1 and B2 receptors also reduced mechanical allodynia, cold sensitivity and overt nociception reserpine-induced. Reserpine altered thigmotaxis, forced swimming and burrowing behaviour in the animals; with the latter being reversed by antagonism of kinin B1 receptor. Moreover, reserpine increased the protein expression of kinin B1 and B2 receptors and levels of kinin, as well as reduced the levels of monoamines in peripheral and central structures. Kinins and its B1 and B2 receptors are involved in fibromyalgia-like pain symptoms. B1 or B2 receptors might represent a potential target for the relief of fibromyalgia-like pain symptoms.

Authors+Show Affiliations

Graduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, RS, Brazil.Graduate Program in Genetics and Biochemistry, Biotechnology Institute, Federal University of Uberlândia, Uberlândia, MG, Brazil.Graduate Program in Genetics and Biochemistry, Biotechnology Institute, Federal University of Uberlândia, Uberlândia, MG, Brazil.Graduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, RS, Brazil.Department of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, SP, Brazil.Graduate Program in Health Sciences, University of Extrem South Catarinense, Criciuma, SC, Brazil.Graduate Program in Health Sciences, University of Extrem South Catarinense, Criciuma, SC, Brazil.Graduate Program in Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.Graduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: saramarchesan@ufsm.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31254493

Citation

Brusco, Indiara, et al. "Kinins and Their B1 and B2 Receptors Are Involved in Fibromyalgia-like Pain Symptoms in Mice." Biochemical Pharmacology, vol. 168, 2019, pp. 119-132.
Brusco I, Justino AB, Silva CR, et al. Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice. Biochem Pharmacol. 2019;168:119-132.
Brusco, I., Justino, A. B., Silva, C. R., Fischer, S., Cunha, T. M., Scussel, R., ... Oliveira, S. M. (2019). Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice. Biochemical Pharmacology, 168, pp. 119-132. doi:10.1016/j.bcp.2019.06.023.
Brusco I, et al. Kinins and Their B1 and B2 Receptors Are Involved in Fibromyalgia-like Pain Symptoms in Mice. Biochem Pharmacol. 2019;168:119-132. PubMed PMID: 31254493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice. AU - Brusco,Indiara, AU - Justino,Allisson Benatti, AU - Silva,Cássia Regina, AU - Fischer,Susana, AU - Cunha,Thiago Mattar, AU - Scussel,Rahisa, AU - Machado-de-Ávila,Ricardo Andrez, AU - Ferreira,Juliano, AU - Oliveira,Sara Marchesan, Y1 - 2019/06/26/ PY - 2019/04/30/received PY - 2019/06/24/accepted PY - 2019/6/30/pubmed PY - 2019/6/30/medline PY - 2019/6/30/entrez KW - Cold sensitivity KW - Mechanical Allodynia KW - Monoamines KW - Overt Nociception KW - Reserpine SP - 119 EP - 132 JF - Biochemical pharmacology JO - Biochem. Pharmacol. VL - 168 N2 - Fibromyalgia is a disease characterised as generalised chronic primary pain that causes functional disability and a reduction in patients' quality of life, without specific pathophysiology or appropriate treatment. Previous studies have shown that kinins and their B1 and B2 receptors contribute to chronic painful conditions. Thus, we investigated the involvement of kinins and their B1 and B2 receptors in a fibromyalgia-like pain model induced by reserpine in mice. Nociceptive parameters (mechanical allodynia, cold sensitivity and overt nociception) and behaviours of burrowing, thigmotaxis, and forced swimming were evaluated after reserpine administration in mice. The role of kinin B1 and B2 receptors was investigated using knockout mice or pharmacological antagonism. The protein expression of kinin B1 and B2 receptors and the levels of bradykinin and monoamines were measured in the sciatic nerve, spinal cord and cerebral cortex of the animals. Knockout mice for the kinin B1 and B2 receptor reduced reserpine-induced mechanical allodynia. Antagonism of B1 and B2 receptors also reduced mechanical allodynia, cold sensitivity and overt nociception reserpine-induced. Reserpine altered thigmotaxis, forced swimming and burrowing behaviour in the animals; with the latter being reversed by antagonism of kinin B1 receptor. Moreover, reserpine increased the protein expression of kinin B1 and B2 receptors and levels of kinin, as well as reduced the levels of monoamines in peripheral and central structures. Kinins and its B1 and B2 receptors are involved in fibromyalgia-like pain symptoms. B1 or B2 receptors might represent a potential target for the relief of fibromyalgia-like pain symptoms. SN - 1873-2968 UR - https://www.unboundmedicine.com/medline/citation/31254493/Kinins_and_their_B1_and_B2_receptors_are_involved_in_fibromyalgia-like_pain_symptoms_in_mice L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(19)30251-5 DB - PRIME DP - Unbound Medicine ER -