Tags

Type your tag names separated by a space and hit enter

Antibiotic-loaded tantalum may serve as an antimicrobial delivery agent.
Bone Joint J 2019; 101-B(7):848-851BJ

Abstract

AIMS

The aims of this study were to compare the mean duration of antibiotic release and the mean zone of inhibition between vancomycin-loaded porous tantalum cylinders and antibiotic-loaded bone cement at intervals, and to evaluate potential intrinsic antimicrobial properties of tantalum in an in vitro medium environment against methicillin-sensitive Staphylococcus aureus (MSSA).

MATERIALS AND METHODS

Ten porous tantalum cylinders and ten cylinders of cement were used. The tantalum cylinders were impregnated with vancomycin, which was also added during preparation of the cylinders of cement. The cylinders were then placed on agar plates inoculated with MSSA. The diameter of the inhibition zone was measured each day, and the cylinders were transferred to a new inoculated plate. Inhibition zones were measured with a Vernier caliper and using an automated computed evaluation, and the intra- and interobserver reproducibility were measured. The mean inhibition zones between the two groups were compared with Wilcoxon's test.

RESULTS

MSSA was inhibited for 12 days by the tantalum cylinders and for nine days by the cement cylinders. At day one, the mean zone of inhibition was 28.6 mm for the tantalum and 19.8 mm for the cement group (p < 0.001). At day ten, the mean zone of inhibition was 3.8 mm for the tantalum and 0 mm for the cement group (p < 0.001). The porous tantalum cylinders soaked only with phosphate buffered solution showed no zone of inhibition.

CONCLUSION

Compared with cement, tantalum could release antibiotics for longer. Further studies should assess the advantages of using antibiotic-loaded porous tantalum implants at revision arthroplasty. Cite this article: Bone Joint J 2019;101-B:848-851.

Authors+Show Affiliations

Institute for Locomotion, Center for Arthritis Surgery, Sainte-Marguerite Hospital, CNRS, Institute of Movement Sciences (ISM), Aix-Marseille University, Marseille, France.Institute for Locomotion, Center for Arthritis Surgery, Sainte-Marguerite Hospital, CNRS, Institute of Movement Sciences (ISM), Aix-Marseille University, Marseille, France.Department of Pharmacology and Toxicology, Timone Hospital, Aix-Marseille University, Marseille, France.Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.Institute for Locomotion, Center for Arthritis Surgery, Sainte-Marguerite Hospital, CNRS, Institute of Movement Sciences (ISM), Aix-Marseille University, Marseille, France.Institute for Locomotion, Center for Arthritis Surgery, Sainte-Marguerite Hospital, CNRS, Institute of Movement Sciences (ISM), Aix-Marseille University, Marseille, France.Institute for Locomotion, Center for Arthritis Surgery, Sainte-Marguerite Hospital, CNRS, Institute of Movement Sciences (ISM), Aix-Marseille University, Marseille, France.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

31256673

Citation

Sautet, P, et al. "Antibiotic-loaded Tantalum May Serve as an Antimicrobial Delivery Agent." The Bone & Joint Journal, vol. 101-B, no. 7, 2019, pp. 848-851.
Sautet P, Parratte S, Mékidèche T, et al. Antibiotic-loaded tantalum may serve as an antimicrobial delivery agent. Bone Joint J. 2019;101-B(7):848-851.
Sautet, P., Parratte, S., Mékidèche, T., Abdel, M. P., Flécher, X., Argenson, J. N., & Ollivier, M. (2019). Antibiotic-loaded tantalum may serve as an antimicrobial delivery agent. The Bone & Joint Journal, 101-B(7), pp. 848-851. doi:10.1302/0301-620X.101B7.BJJ-2018-1206.R1.
Sautet P, et al. Antibiotic-loaded Tantalum May Serve as an Antimicrobial Delivery Agent. Bone Joint J. 2019;101-B(7):848-851. PubMed PMID: 31256673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic-loaded tantalum may serve as an antimicrobial delivery agent. AU - Sautet,P, AU - Parratte,S, AU - Mékidèche,T, AU - Abdel,M P, AU - Flécher,X, AU - Argenson,J-N, AU - Ollivier,M, PY - 2019/7/2/entrez PY - 2019/7/2/pubmed PY - 2019/7/2/medline KW - Antibiotic-loaded KW - Antimicrobial KW - Infection KW - Tantalum KW - Vancomycin SP - 848 EP - 851 JF - The bone & joint journal JO - Bone Joint J VL - 101-B IS - 7 N2 - AIMS: The aims of this study were to compare the mean duration of antibiotic release and the mean zone of inhibition between vancomycin-loaded porous tantalum cylinders and antibiotic-loaded bone cement at intervals, and to evaluate potential intrinsic antimicrobial properties of tantalum in an in vitro medium environment against methicillin-sensitive Staphylococcus aureus (MSSA). MATERIALS AND METHODS: Ten porous tantalum cylinders and ten cylinders of cement were used. The tantalum cylinders were impregnated with vancomycin, which was also added during preparation of the cylinders of cement. The cylinders were then placed on agar plates inoculated with MSSA. The diameter of the inhibition zone was measured each day, and the cylinders were transferred to a new inoculated plate. Inhibition zones were measured with a Vernier caliper and using an automated computed evaluation, and the intra- and interobserver reproducibility were measured. The mean inhibition zones between the two groups were compared with Wilcoxon's test. RESULTS: MSSA was inhibited for 12 days by the tantalum cylinders and for nine days by the cement cylinders. At day one, the mean zone of inhibition was 28.6 mm for the tantalum and 19.8 mm for the cement group (p < 0.001). At day ten, the mean zone of inhibition was 3.8 mm for the tantalum and 0 mm for the cement group (p < 0.001). The porous tantalum cylinders soaked only with phosphate buffered solution showed no zone of inhibition. CONCLUSION: Compared with cement, tantalum could release antibiotics for longer. Further studies should assess the advantages of using antibiotic-loaded porous tantalum implants at revision arthroplasty. Cite this article: Bone Joint J 2019;101-B:848-851. SN - 2049-4408 UR - https://www.unboundmedicine.com/medline/citation/31256673/Antibiotic-loaded_tantalum_may_serve_as_an_antimicrobial_delivery_agent L2 - https://online.boneandjoint.org.uk/doi/full/10.1302/0301-620X.101B7.BJJ-2018-1206.R1?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -