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Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients.
Oral Dis. 2019 Oct; 25(7):1798-1808.OD

Abstract

OBJECTIVES

To evaluate (a) oral colonization of Candida species, especially for non-albicans Candida species (NACS), in xerostomic postradiotherapy head and neck cancer patients and (b) risk factors affecting their colonization.

MATERIALS AND METHODS

Subjective and objective dry mouth scores, stimulated salivary flow rates, pH and buffering capacity were measured in 72 xerostomic postradiotherapy head and neck cancer patients. Candida counts and species identification were performed using oral rinse samples cultured in Candida Chromagar, followed by polymerase chain reaction and API 20C AUX system.

RESULTS

Candida colonization was observed in 87.5% of subjects, with 80.6% and 48.6% of study population colonized by C. albicans and NACS, respectively. NACS was associated with high objective dry mouth scores, denture use, and females (p = .006, .009, and .036, respectively). In addition, Candida glabrata was detected more in females (p = .018) and denture wearers (p = .026), while Candida tropicalis was associated with high objective dry mouth scores (p = .022) and females (p = .027). Quantity of Candida colonization correlated positively with objective dry mouth scores (r = 0.599, p < .001) and negatively with salivary flow rates (r = -0.258, p = .041) and pH (r = -0.290, p = .022).

CONCLUSION

NACS colonization was common in xerostomic head and neck cancer patients. Increased signs of dry mouth, female and dental prostheses may promote NACS colonization.

Authors+Show Affiliations

Faculty of Dentistry, Srinakharinwirot University, Bangkok, Thailand.Department of Microbiology and Research Unit on Oral Microbiology and Immunology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Laboratory of Biotechnology, Chulabhorn Research Institute, Bangkok, Thailand.Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.Faculty of Dentistry, Mahidol University, Bangkok, Thailand.Faculty of Dentistry, Srinakharinwirot University, Bangkok, Thailand.Chulabhorn Hospital, Bangkok, Thailand.Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.Chonburi Cancer Hospital, Chonburi, Thailand.Chonburi Cancer Hospital, Chonburi, Thailand.Faculty of Dentistry, Srinakharinwirot University, Bangkok, Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31257663

Citation

Tarapan, Supanat, et al. "Oral Candida Colonization in Xerostomic Postradiotherapy Head and Neck Cancer Patients." Oral Diseases, vol. 25, no. 7, 2019, pp. 1798-1808.
Tarapan S, Matangkasombut O, Trachootham D, et al. Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients. Oral Dis. 2019;25(7):1798-1808.
Tarapan, S., Matangkasombut, O., Trachootham, D., Sattabanasuk, V., Talungchit, S., Paemuang, W., Phonyiam, T., Chokchaitam, O., Mungkung, O. O., & Lam-Ubol, A. (2019). Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients. Oral Diseases, 25(7), 1798-1808. https://doi.org/10.1111/odi.13151
Tarapan S, et al. Oral Candida Colonization in Xerostomic Postradiotherapy Head and Neck Cancer Patients. Oral Dis. 2019;25(7):1798-1808. PubMed PMID: 31257663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients. AU - Tarapan,Supanat, AU - Matangkasombut,Oranart, AU - Trachootham,Dunyaporn, AU - Sattabanasuk,Vanthana, AU - Talungchit,Sineepat, AU - Paemuang,Wannaporn, AU - Phonyiam,Tawaree, AU - Chokchaitam,Orapin, AU - Mungkung,On-Ong, AU - Lam-Ubol,Aroonwan, Y1 - 2019/08/01/ PY - 2019/04/13/received PY - 2019/06/16/revised PY - 2019/06/25/accepted PY - 2019/7/2/pubmed PY - 2020/1/3/medline PY - 2019/7/2/entrez KW - Candida KW - head and neck cancer KW - hyposalivation KW - non-albicans KW - xerostomia SP - 1798 EP - 1808 JF - Oral diseases JO - Oral Dis VL - 25 IS - 7 N2 - OBJECTIVES: To evaluate (a) oral colonization of Candida species, especially for non-albicans Candida species (NACS), in xerostomic postradiotherapy head and neck cancer patients and (b) risk factors affecting their colonization. MATERIALS AND METHODS: Subjective and objective dry mouth scores, stimulated salivary flow rates, pH and buffering capacity were measured in 72 xerostomic postradiotherapy head and neck cancer patients. Candida counts and species identification were performed using oral rinse samples cultured in Candida Chromagar, followed by polymerase chain reaction and API 20C AUX system. RESULTS: Candida colonization was observed in 87.5% of subjects, with 80.6% and 48.6% of study population colonized by C. albicans and NACS, respectively. NACS was associated with high objective dry mouth scores, denture use, and females (p = .006, .009, and .036, respectively). In addition, Candida glabrata was detected more in females (p = .018) and denture wearers (p = .026), while Candida tropicalis was associated with high objective dry mouth scores (p = .022) and females (p = .027). Quantity of Candida colonization correlated positively with objective dry mouth scores (r = 0.599, p < .001) and negatively with salivary flow rates (r = -0.258, p = .041) and pH (r = -0.290, p = .022). CONCLUSION: NACS colonization was common in xerostomic head and neck cancer patients. Increased signs of dry mouth, female and dental prostheses may promote NACS colonization. SN - 1601-0825 UR - https://www.unboundmedicine.com/medline/citation/31257663/Oral_Candida_colonization_in_xerostomic_postradiotherapy_head_and_neck_cancer_patients L2 - https://doi.org/10.1111/odi.13151 DB - PRIME DP - Unbound Medicine ER -