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Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6: A Preliminary Report from Istanbul.
Pol J Microbiol. 2019; 68(2):165-171.PJ

Abstract

Hand, foot, and mouth disease (HFMD) is caused by various serotypes of Enterovirus genus. Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) were known to be the only responsible agents for these epidemics; however, this opinion was challenged after the detection that coxsackievirus A6 (CV-A6) was the responsible species for the outbreak in Finland in 2008. HFMD is frequently seen in Turkey, and no detailed study on its clinical and microbiological epidemiology has previously been reported. The present study addresses this question. Twenty-seven patient samples collected between 2015 and 2017 were included in the study. Typing was conducted by RT-PCR and the sequencing applied directly to patient's samples and as well as to the viral cultures with pan-enterovirus and serotype-specific primers. The presence of Enterovirus in 12 of 27 HFMD samples was shown with RT-PCR. The causative agent for three of these 12 samples was CV-A16, one of the most frequent two serotypes around the world, and the remaining nine samples was CV-A6. The findings of the study are relevant since it pertains to the molecular epidemiology of HFMD in Turkey, a gateway country where different serotypes might be circulating and transmitted. The findings also support the notion that CV-A6 cases are rising in number, which has caused more severe clinical features and widespread rashes in recent outbreaks.

Hand, foot, and mouth disease (HFMD) is caused by various serotypes of Enterovirus genus. Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) were known to be the only responsible agents for these epidemics; however, this opinion was challenged after the detection that coxsackievirus A6 (CV-A6) was the responsible species for the outbreak in Finland in 2008. HFMD is frequently seen in Turkey, and no detailed study on its clinical and microbiological epidemiology has previously been reported. The present study addresses this question. Twenty-seven patient samples collected between 2015 and 2017 were included in the study. Typing was conducted by RT-PCR and the sequencing applied directly to patient’s samples and as well as to the viral cultures with pan-enterovirus and serotype-specific primers. The presence of Enterovirus in 12 of 27 HFMD samples was shown with RT-PCR. The causative agent for three of these 12 samples was CV-A16, one of the most frequent two serotypes around the world, and the remaining nine samples was CV-A6. The findings of the study are relevant since it pertains to the molecular epidemiology of HFMD in Turkey, a gateway country where different serotypes might be circulating and transmitted. The findings also support the notion that CV-A6 cases are rising in number, which has caused more severe clinical features and widespread rashes in recent outbreaks.

Authors+Show Affiliations

Bezmialem Vakif University, Department of Medical Microbiology , Istanbul , Turkey.Bezmialem Vakif University, Department of Pediatrics , Istanbul , Turkey.Bezmialem Vakif University, Department of Medical Microbiology , Istanbul , Turkey.Bezmialem Vakif University, Department of Pediatrics , Istanbul , Turkey.Bezmialem Vakif University, Department of Pediatrics , Istanbul , Turkey.Bezmialem Vakif University, Department of Medical Microbiology , Istanbul , Turkey ; Bezmialem Vakif University, Beykoz Institute of Life Sciences and Biotechnology (BILSAB) , Istanbul , Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31257789

Citation

Ceylan, Ayse N., et al. "Hand, Foot, and Mouth Disease Caused By Coxsackievirus A6: a Preliminary Report From Istanbul." Polish Journal of Microbiology, vol. 68, no. 2, 2019, pp. 165-171.
Ceylan AN, Turel O, Gultepe BS, et al. Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6: A Preliminary Report from Istanbul. Pol J Microbiol. 2019;68(2):165-171.
Ceylan, A. N., Turel, O., Gultepe, B. S., Inan, E., Turkmen, A. V., & Doymaz, M. Z. (2019). Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6: A Preliminary Report from Istanbul. Polish Journal of Microbiology, 68(2), 165-171. https://doi.org/10.33073/pjm-2019-016
Ceylan AN, et al. Hand, Foot, and Mouth Disease Caused By Coxsackievirus A6: a Preliminary Report From Istanbul. Pol J Microbiol. 2019;68(2):165-171. PubMed PMID: 31257789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6: A Preliminary Report from Istanbul. AU - Ceylan,Ayse N, AU - Turel,Ozden, AU - Gultepe,Bilge Sumbul, AU - Inan,Elif, AU - Turkmen,Aysel Vehapoglu, AU - Doymaz,Mehmet Z, PY - 2018/10/01/received PY - 2019/01/07/revised PY - 2019/01/07/accepted PY - 2019/7/2/entrez PY - 2019/7/2/pubmed PY - 2019/7/18/medline SP - 165 EP - 171 JF - Polish journal of microbiology JO - Pol. J. Microbiol. VL - 68 IS - 2 N2 - Hand, foot, and mouth disease (HFMD) is caused by various serotypes of Enterovirus genus. Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) were known to be the only responsible agents for these epidemics; however, this opinion was challenged after the detection that coxsackievirus A6 (CV-A6) was the responsible species for the outbreak in Finland in 2008. HFMD is frequently seen in Turkey, and no detailed study on its clinical and microbiological epidemiology has previously been reported. The present study addresses this question. Twenty-seven patient samples collected between 2015 and 2017 were included in the study. Typing was conducted by RT-PCR and the sequencing applied directly to patient's samples and as well as to the viral cultures with pan-enterovirus and serotype-specific primers. The presence of Enterovirus in 12 of 27 HFMD samples was shown with RT-PCR. The causative agent for three of these 12 samples was CV-A16, one of the most frequent two serotypes around the world, and the remaining nine samples was CV-A6. The findings of the study are relevant since it pertains to the molecular epidemiology of HFMD in Turkey, a gateway country where different serotypes might be circulating and transmitted. The findings also support the notion that CV-A6 cases are rising in number, which has caused more severe clinical features and widespread rashes in recent outbreaks. Hand, foot, and mouth disease (HFMD) is caused by various serotypes of Enterovirus genus. Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) were known to be the only responsible agents for these epidemics; however, this opinion was challenged after the detection that coxsackievirus A6 (CV-A6) was the responsible species for the outbreak in Finland in 2008. HFMD is frequently seen in Turkey, and no detailed study on its clinical and microbiological epidemiology has previously been reported. The present study addresses this question. Twenty-seven patient samples collected between 2015 and 2017 were included in the study. Typing was conducted by RT-PCR and the sequencing applied directly to patient’s samples and as well as to the viral cultures with pan-enterovirus and serotype-specific primers. The presence of Enterovirus in 12 of 27 HFMD samples was shown with RT-PCR. The causative agent for three of these 12 samples was CV-A16, one of the most frequent two serotypes around the world, and the remaining nine samples was CV-A6. The findings of the study are relevant since it pertains to the molecular epidemiology of HFMD in Turkey, a gateway country where different serotypes might be circulating and transmitted. The findings also support the notion that CV-A6 cases are rising in number, which has caused more severe clinical features and widespread rashes in recent outbreaks. SN - 2544-4646 UR - https://www.unboundmedicine.com/medline/citation/31257789/Hand_Foot_and_Mouth_Disease_Caused_by_Coxsackievirus_A6:_A_Preliminary_Report_from_Istanbul_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31257789/ DB - PRIME DP - Unbound Medicine ER -