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The role of the fibroblast growth factor family in bone-related diseases.
Chem Biol Drug Des. 2019 10; 94(4):1740-1749.CB

Abstract

Fibroblast growth factor (FGF) family members are important regulators of cell growth, proliferation, differentiation, and regeneration. The abnormal expression of certain FGF family members can cause skeletal diseases, including achondroplasia, craniosynostosis syndrome, osteoarthritis, and Kashin-Beck disease. Accumulating evidence shows that FGFs play a crucial role in the growth and proliferation of bone and in the pathogenesis of certain bone-related diseases. Here, we review the involvement of FGFs in bone-related processes and diseases; FGF1 in the differentiation of human bone marrow mesenchymal stem cells and fracture repair; FGF2, FGF9, and FGF18 in osteoarthritis; FGF6 in bone and muscle injury; FGF8 in osteoarthritis and Kashin-Beck disease; and FGF21 and FGF23 on bone regulation. These findings indicate that FGFs are targets for novel therapeutic interventions for bone-related diseases.

Authors+Show Affiliations

Department of Orthopaedics, Shaanxi Provincial People's Hospital, Xi'an, China. Xi'an Medical University, Xi'an, China.Department of Orthopaedics, Shaanxi Provincial People's Hospital, Xi'an, China.Department of Orthopaedics, Shaanxi Provincial People's Hospital, Xi'an, China.Department of Orthopaedics, Shaanxi Provincial People's Hospital, Xi'an, China.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31260189

Citation

Wang, Jicheng, et al. "The Role of the Fibroblast Growth Factor Family in Bone-related Diseases." Chemical Biology & Drug Design, vol. 94, no. 4, 2019, pp. 1740-1749.
Wang J, Liu S, Li J, et al. The role of the fibroblast growth factor family in bone-related diseases. Chem Biol Drug Des. 2019;94(4):1740-1749.
Wang, J., Liu, S., Li, J., & Yi, Z. (2019). The role of the fibroblast growth factor family in bone-related diseases. Chemical Biology & Drug Design, 94(4), 1740-1749. https://doi.org/10.1111/cbdd.13588
Wang J, et al. The Role of the Fibroblast Growth Factor Family in Bone-related Diseases. Chem Biol Drug Des. 2019;94(4):1740-1749. PubMed PMID: 31260189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of the fibroblast growth factor family in bone-related diseases. AU - Wang,Jicheng, AU - Liu,Shizhang, AU - Li,Jingyuan, AU - Yi,Zhi, Y1 - 2019/08/04/ PY - 2019/02/16/received PY - 2019/04/25/revised PY - 2019/06/17/accepted PY - 2019/7/2/pubmed PY - 2019/7/2/medline PY - 2019/7/2/entrez KW - abnormal expression KW - bone-related diseases KW - fibroblast growth factor KW - targeted therapy SP - 1740 EP - 1749 JF - Chemical biology & drug design JO - Chem Biol Drug Des VL - 94 IS - 4 N2 - Fibroblast growth factor (FGF) family members are important regulators of cell growth, proliferation, differentiation, and regeneration. The abnormal expression of certain FGF family members can cause skeletal diseases, including achondroplasia, craniosynostosis syndrome, osteoarthritis, and Kashin-Beck disease. Accumulating evidence shows that FGFs play a crucial role in the growth and proliferation of bone and in the pathogenesis of certain bone-related diseases. Here, we review the involvement of FGFs in bone-related processes and diseases; FGF1 in the differentiation of human bone marrow mesenchymal stem cells and fracture repair; FGF2, FGF9, and FGF18 in osteoarthritis; FGF6 in bone and muscle injury; FGF8 in osteoarthritis and Kashin-Beck disease; and FGF21 and FGF23 on bone regulation. These findings indicate that FGFs are targets for novel therapeutic interventions for bone-related diseases. SN - 1747-0285 UR - https://www.unboundmedicine.com/medline/citation/31260189/The_role_of_the_fibroblast_growth_factor_family_in_bone-related_diseases L2 - https://doi.org/10.1111/cbdd.13588 DB - PRIME DP - Unbound Medicine ER -
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