Tags

Type your tag names separated by a space and hit enter

The role of mast cells in pediatric gastrointestinal disease.
Ann Gastroenterol 2019 Jul-Aug; 32(4):338-345AG

Abstract

Mast cells are granulocytes derived from CD34+ pluripotent progenitor cells that demonstrate plasticity in their development, leaving the bone marrow and differentiating in the tissue where they ultimately reside. They are best known for their role in the allergic response, but also play a prominent immunoregulatory role in other processes, including immune tolerance, the innate immune response, angiogenesis, wound healing and tissue remodeling. Mast cells are found throughout the gastrointestinal tract; their metabolic products influence and regulate intestinal epithelial and endothelial function, gastrointestinal secretion, intestinal motility and absorption, and contribute to host defense. They also play an important role in the development of visceral hypersensitivity through bidirectional interaction with the enteric nervous system. Mast cells have been found to have an increasingly important role in the pathophysiology of a number of pediatric gastrointestinal diseases. This review summarizes the current understanding of the role that mast cells play in the development of pediatric gastrointestinal disorders, including eosinophilic esophagitis, functional dyspepsia, irritable bowel syndrome, celiac disease, inflammatory bowel disease, histologically negative appendicitis, Hirschsprung's disease, intestinal neuronal dysplasia, and food protein-induced enterocolitis syndrome.

Authors+Show Affiliations

Department of Pediatrics (Naseem Ravanbakhsh).Section of Pediatric Gastroenterology (Anil Kesavan), Rush University Children's Hospital, Chicago, IL, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31263355

Citation

Ravanbakhsh, Naseem, and Anil Kesavan. "The Role of Mast Cells in Pediatric Gastrointestinal Disease." Annals of Gastroenterology, vol. 32, no. 4, 2019, pp. 338-345.
Ravanbakhsh N, Kesavan A. The role of mast cells in pediatric gastrointestinal disease. Ann Gastroenterol. 2019;32(4):338-345.
Ravanbakhsh, N., & Kesavan, A. (2019). The role of mast cells in pediatric gastrointestinal disease. Annals of Gastroenterology, 32(4), pp. 338-345. doi:10.20524/aog.2019.0378.
Ravanbakhsh N, Kesavan A. The Role of Mast Cells in Pediatric Gastrointestinal Disease. Ann Gastroenterol. 2019;32(4):338-345. PubMed PMID: 31263355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of mast cells in pediatric gastrointestinal disease. AU - Ravanbakhsh,Naseem, AU - Kesavan,Anil, Y1 - 2019/04/22/ PY - 2018/09/12/received PY - 2019/04/02/accepted PY - 2019/7/3/entrez PY - 2019/7/3/pubmed PY - 2019/7/3/medline KW - Hirschsprung’s disease KW - Mast cell KW - eosinophilic esophagitis KW - food protein induced enterocolitis syndrome KW - functional dyspepsia KW - histologically negative appendicitis KW - inflammatory bowel disease KW - intestinal neuronal dysplasia KW - irritable bowel syndrome SP - 338 EP - 345 JF - Annals of gastroenterology JO - Ann Gastroenterol VL - 32 IS - 4 N2 - Mast cells are granulocytes derived from CD34+ pluripotent progenitor cells that demonstrate plasticity in their development, leaving the bone marrow and differentiating in the tissue where they ultimately reside. They are best known for their role in the allergic response, but also play a prominent immunoregulatory role in other processes, including immune tolerance, the innate immune response, angiogenesis, wound healing and tissue remodeling. Mast cells are found throughout the gastrointestinal tract; their metabolic products influence and regulate intestinal epithelial and endothelial function, gastrointestinal secretion, intestinal motility and absorption, and contribute to host defense. They also play an important role in the development of visceral hypersensitivity through bidirectional interaction with the enteric nervous system. Mast cells have been found to have an increasingly important role in the pathophysiology of a number of pediatric gastrointestinal diseases. This review summarizes the current understanding of the role that mast cells play in the development of pediatric gastrointestinal disorders, including eosinophilic esophagitis, functional dyspepsia, irritable bowel syndrome, celiac disease, inflammatory bowel disease, histologically negative appendicitis, Hirschsprung's disease, intestinal neuronal dysplasia, and food protein-induced enterocolitis syndrome. SN - 1108-7471 UR - https://www.unboundmedicine.com/medline/citation/31263355/The_role_of_mast_cells_in_pediatric_gastrointestinal_disease L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31263355/ DB - PRIME DP - Unbound Medicine ER -