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Chronic alcohol abuse leads to gastric atrophy and decreased gastric secretory capacity: a histological and physiological study.
Am J Gastroenterol. 1988 Apr; 83(4):373-9.AJ

Abstract

We performed morphological and physiological studies in 43 male patients with alcohol dependence (ALC) who had no other apparent lesions in the upper gastrointestinal tract except atrophic and erosive gastritis. A gastric secretory study in which tetragastrin was used as the stimulant revealed that acid and pepsin secretion was less in ALC patients than in hospital controls (p less than 0.001). Endoscopic biopsy specimens of gastric mucosa from ALC patients revealed that atrophy of the gastric mucosa advanced with age. A strong negative correlation was also found between the secretory capacity of the stomach and the degree of atrophy. Possibly, the interval between recurrent episodes of acute mucosal damage was too short to allow complete healing of mucosal lesions. Failure to regenerate denuded epithelium would result in a decrease in the gastric secretory area. Thus, chronic alcohol abuse seems to be an etiological factor in atrophic gastritis.

Authors+Show Affiliations

Segawa K
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Nakazawa S
No affiliation info available
Tsukamoto Y
No affiliation info available
Goto H
No affiliation info available
Yamao K
No affiliation info available
Hase S
No affiliation info available
Osada T
No affiliation info available
Arisawa T
No affiliation info available

MeSH

AdultAge FactorsAgedAlcoholismAtrophyGastric AcidGastric MucosaGastritisHumansMaleMiddle AgedPepsin AStomach

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3126647

Citation

Segawa, K, et al. "Chronic Alcohol Abuse Leads to Gastric Atrophy and Decreased Gastric Secretory Capacity: a Histological and Physiological Study." The American Journal of Gastroenterology, vol. 83, no. 4, 1988, pp. 373-9.
Segawa K, Nakazawa S, Tsukamoto Y, et al. Chronic alcohol abuse leads to gastric atrophy and decreased gastric secretory capacity: a histological and physiological study. Am J Gastroenterol. 1988;83(4):373-9.
Segawa, K., Nakazawa, S., Tsukamoto, Y., Goto, H., Yamao, K., Hase, S., Osada, T., & Arisawa, T. (1988). Chronic alcohol abuse leads to gastric atrophy and decreased gastric secretory capacity: a histological and physiological study. The American Journal of Gastroenterology, 83(4), 373-9.
Segawa K, et al. Chronic Alcohol Abuse Leads to Gastric Atrophy and Decreased Gastric Secretory Capacity: a Histological and Physiological Study. Am J Gastroenterol. 1988;83(4):373-9. PubMed PMID: 3126647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic alcohol abuse leads to gastric atrophy and decreased gastric secretory capacity: a histological and physiological study. AU - Segawa,K, AU - Nakazawa,S, AU - Tsukamoto,Y, AU - Goto,H, AU - Yamao,K, AU - Hase,S, AU - Osada,T, AU - Arisawa,T, PY - 1988/4/1/pubmed PY - 1988/4/1/medline PY - 1988/4/1/entrez SP - 373 EP - 9 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 83 IS - 4 N2 - We performed morphological and physiological studies in 43 male patients with alcohol dependence (ALC) who had no other apparent lesions in the upper gastrointestinal tract except atrophic and erosive gastritis. A gastric secretory study in which tetragastrin was used as the stimulant revealed that acid and pepsin secretion was less in ALC patients than in hospital controls (p less than 0.001). Endoscopic biopsy specimens of gastric mucosa from ALC patients revealed that atrophy of the gastric mucosa advanced with age. A strong negative correlation was also found between the secretory capacity of the stomach and the degree of atrophy. Possibly, the interval between recurrent episodes of acute mucosal damage was too short to allow complete healing of mucosal lesions. Failure to regenerate denuded epithelium would result in a decrease in the gastric secretory area. Thus, chronic alcohol abuse seems to be an etiological factor in atrophic gastritis. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/3126647/Chronic_alcohol_abuse_leads_to_gastric_atrophy_and_decreased_gastric_secretory_capacity:_a_histological_and_physiological_study_ DB - PRIME DP - Unbound Medicine ER -