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Spectral Analysis of Codons in the DNA Sequence of Fragile X Syndrome.
J Med Syst 2019; 43(8):261JM

Abstract

There are frequent studies undergoing related to the Fragile X syndrome caused due to the triplet CGG replicates on the X chromosome of Fragile X Mental Retardation 1 (FMR1) gene. Mutations of this chromosome can lead to Fragile X syndrome, rational disability, and other cognitive discrepancies. A novel approach based on Rajan Transform is proposed to analyze the spectral density of codons. The traditional transform like Fourier transform provides imaginary values whereas the Rajan Transform exhibits only the real values. The mutations there in the DNA are successfully distinguished by using the Rajan Transform which is suitable tool for the spectral analysis of DNA sequences. The utilization of the Rajan Transform urges larger profits in terms of minimal false alarm rate and thereby leading to an increase in the accuracy of the spectral analysis.

Authors+Show Affiliations

Department of Mathematics, Thiagarajar College of Engineering, Madurai, Tamil Nadu, India.Department of Mathematics, Thiagarajar College of Engineering, Madurai, Tamil Nadu, India. mailtobalamaths@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31267258

Citation

S, Jeya Bharathi, and Balamanikandan P. "Spectral Analysis of Codons in the DNA Sequence of Fragile X Syndrome." Journal of Medical Systems, vol. 43, no. 8, 2019, p. 261.
S JB, P B. Spectral Analysis of Codons in the DNA Sequence of Fragile X Syndrome. J Med Syst. 2019;43(8):261.
S, J. B., & P, B. (2019). Spectral Analysis of Codons in the DNA Sequence of Fragile X Syndrome. Journal of Medical Systems, 43(8), p. 261. doi:10.1007/s10916-019-1408-0.
S JB, P B. Spectral Analysis of Codons in the DNA Sequence of Fragile X Syndrome. J Med Syst. 2019 Jul 2;43(8):261. PubMed PMID: 31267258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spectral Analysis of Codons in the DNA Sequence of Fragile X Syndrome. AU - S,Jeya Bharathi, AU - P,Balamanikandan, Y1 - 2019/07/02/ PY - 2019/03/20/received PY - 2019/06/26/accepted PY - 2019/7/4/entrez PY - 2019/7/4/pubmed PY - 2019/7/4/medline KW - Autocorrelation KW - Codon KW - Fourier transform KW - Fragile X syndrome KW - Rajan transform SP - 261 EP - 261 JF - Journal of medical systems JO - J Med Syst VL - 43 IS - 8 N2 - There are frequent studies undergoing related to the Fragile X syndrome caused due to the triplet CGG replicates on the X chromosome of Fragile X Mental Retardation 1 (FMR1) gene. Mutations of this chromosome can lead to Fragile X syndrome, rational disability, and other cognitive discrepancies. A novel approach based on Rajan Transform is proposed to analyze the spectral density of codons. The traditional transform like Fourier transform provides imaginary values whereas the Rajan Transform exhibits only the real values. The mutations there in the DNA are successfully distinguished by using the Rajan Transform which is suitable tool for the spectral analysis of DNA sequences. The utilization of the Rajan Transform urges larger profits in terms of minimal false alarm rate and thereby leading to an increase in the accuracy of the spectral analysis. SN - 1573-689X UR - https://www.unboundmedicine.com/medline/citation/31267258/Spectral_Analysis_of_Codons_in_the_DNA_Sequence_of_Fragile_X_Syndrome L2 - https://dx.doi.org/10.1007/s10916-019-1408-0 DB - PRIME DP - Unbound Medicine ER -
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