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The Nitrogen Isotope Ratio Is a Biomarker of Yup'ik Traditional Food Intake and Reflects Dietary Seasonality in Segmental Hair Analyses.
J Nutr. 2019 11 01; 149(11):1960-1966.JN

Abstract

BACKGROUND

The nitrogen isotope ratio (NIR) is a promising index of traditional food intake for an Alaska Native (Yup'ik) population, which can be measured in blood and hair. However, the NIR has not been calibrated to high-quality measures of Yup'ik traditional food intake.

OBJECTIVES

Our primary objective was to examine associations between intakes of Yup'ik traditional food groups, including fish, marine mammals, birds, land mammals, berries, greens, and total traditional foods, and the NIR. In an exploratory analysis, we also examined whether NIR analyzed sequentially along hair could reflect dietary seasonality.

METHODS

We recruited 68 participants from 2 Yup'ik communities in the Yukon Kuskokwim region of Southwest Alaska (49% female, aged 14-79 y). Participants completed 4 unscheduled 24-h food recalls over the period peak of RBC and hair synthesis preceding a specimen collection visit. The NIR was measured in RBCs (n = 68), a proximal hair section (n = 58), and sequential segments of hair from individuals in the upper 2 quartiles of traditional food intake having hair >6 cm in length, plus 2 low subsistence participants for reference (n = 18). Diet-biomarker associations were assessed using Pearson's correlation and linear regression.

RESULTS

Intakes of fish, marine mammals, berries, and greens were significantly associated with the NIR. The strongest dietary association was with total traditional food intake (R2 = 0.62), which indicated that each 1‰ increase in the RBC NIR corresponded to 8% of energy from traditional foods. Hair NIR appeared to fluctuate seasonally in some individuals, peaking in the summertime.

CONCLUSIONS

Findings support the use of the RBC and hair NIR to assess total traditional food intake in a Yup'ik population. Analyses of sequential hair NIR provided evidence of seasonality in traditional food intake, although seasonal variations were modest relative to interindividual variation.

Authors+Show Affiliations

Department of Cultural Anthropology, Hanyang University ERICA, Ansan, South Korea. Center for Alaska Native Health Research, Institute for Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA.Center for Alaska Native Health Research, Institute for Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA. Department of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK, USA.Department of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK, USA.Center for Alaska Native Health Research, Institute for Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA. Department of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK, USA.Center for Alaska Native Health Research, Institute for Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA. Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA.Center for Alaska Native Health Research, Institute for Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA. Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA.Center for Alaska Native Health Research, Institute for Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA. Department of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31268149

Citation

Choy, Kyungcheol, et al. "The Nitrogen Isotope Ratio Is a Biomarker of Yup'ik Traditional Food Intake and Reflects Dietary Seasonality in Segmental Hair Analyses." The Journal of Nutrition, vol. 149, no. 11, 2019, pp. 1960-1966.
Choy K, Nash SH, Hill C, et al. The Nitrogen Isotope Ratio Is a Biomarker of Yup'ik Traditional Food Intake and Reflects Dietary Seasonality in Segmental Hair Analyses. J Nutr. 2019;149(11):1960-1966.
Choy, K., Nash, S. H., Hill, C., Bersamin, A., Hopkins, S. E., Boyer, B. B., & O'Brien, D. M. (2019). The Nitrogen Isotope Ratio Is a Biomarker of Yup'ik Traditional Food Intake and Reflects Dietary Seasonality in Segmental Hair Analyses. The Journal of Nutrition, 149(11), 1960-1966. https://doi.org/10.1093/jn/nxz144
Choy K, et al. The Nitrogen Isotope Ratio Is a Biomarker of Yup'ik Traditional Food Intake and Reflects Dietary Seasonality in Segmental Hair Analyses. J Nutr. 2019 11 1;149(11):1960-1966. PubMed PMID: 31268149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Nitrogen Isotope Ratio Is a Biomarker of Yup'ik Traditional Food Intake and Reflects Dietary Seasonality in Segmental Hair Analyses. AU - Choy,Kyungcheol, AU - Nash,Sarah H, AU - Hill,Courtney, AU - Bersamin,Andrea, AU - Hopkins,Scarlett E, AU - Boyer,Bert B, AU - O'Brien,Diane M, PY - 2019/05/14/received PY - 2019/05/29/revised PY - 2019/06/04/accepted PY - 2019/7/4/pubmed PY - 2020/6/27/medline PY - 2019/7/4/entrez KW - biomarker evaluation KW - circumpolar health KW - dietary seasonality KW - nitrogen stable isotope ratio KW - traditional food SP - 1960 EP - 1966 JF - The Journal of nutrition JO - J Nutr VL - 149 IS - 11 N2 - BACKGROUND: The nitrogen isotope ratio (NIR) is a promising index of traditional food intake for an Alaska Native (Yup'ik) population, which can be measured in blood and hair. However, the NIR has not been calibrated to high-quality measures of Yup'ik traditional food intake. OBJECTIVES: Our primary objective was to examine associations between intakes of Yup'ik traditional food groups, including fish, marine mammals, birds, land mammals, berries, greens, and total traditional foods, and the NIR. In an exploratory analysis, we also examined whether NIR analyzed sequentially along hair could reflect dietary seasonality. METHODS: We recruited 68 participants from 2 Yup'ik communities in the Yukon Kuskokwim region of Southwest Alaska (49% female, aged 14-79 y). Participants completed 4 unscheduled 24-h food recalls over the period peak of RBC and hair synthesis preceding a specimen collection visit. The NIR was measured in RBCs (n = 68), a proximal hair section (n = 58), and sequential segments of hair from individuals in the upper 2 quartiles of traditional food intake having hair >6 cm in length, plus 2 low subsistence participants for reference (n = 18). Diet-biomarker associations were assessed using Pearson's correlation and linear regression. RESULTS: Intakes of fish, marine mammals, berries, and greens were significantly associated with the NIR. The strongest dietary association was with total traditional food intake (R2 = 0.62), which indicated that each 1‰ increase in the RBC NIR corresponded to 8% of energy from traditional foods. Hair NIR appeared to fluctuate seasonally in some individuals, peaking in the summertime. CONCLUSIONS: Findings support the use of the RBC and hair NIR to assess total traditional food intake in a Yup'ik population. Analyses of sequential hair NIR provided evidence of seasonality in traditional food intake, although seasonal variations were modest relative to interindividual variation. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/31268149/The_Nitrogen_Isotope_Ratio_Is_a_Biomarker_of_Yup'ik_Traditional_Food_Intake_and_Reflects_Dietary_Seasonality_in_Segmental_Hair_Analyses_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/nxz144 DB - PRIME DP - Unbound Medicine ER -