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Locomotor sensitization in male Sprague-Dawley rats following repeated concurrent treatment with 4-methylmethcathinone and 3,4-methylenedioxymethamphetamine.
Behav Pharmacol. 2019 10; 30(7):566-573.BP

Abstract

Recreational abuse of illicit synthetic cathinones is an ongoing public health concern. Recent studies indicate that the methcathinone derivative 4-methylmethcathinone (4-MMC) produces behavioral and neurochemical effects similar to the entactogen 3,4-methylenedioxymethamphetamine (MDMA). Whereas polysubstance abuse is common, most preclinical studies of drug abuse liability only evaluate the effects of single drugs. Utilizing the locomotor sensitization paradigm, the present study assessed the combined locomotor stimulant effects of 4-MMC and MDMA for induction of sensitization following repeated administration and for expression of sensitization to a challenge dose of either substance alone after a 10-day period of drug abstinence. Male Sprague-Dawley rats received once daily intraperitoneal injections of saline, 4-MMC (1.0 mg/kg or 5.0 mg/kg), MDMA (3.0 mg/kg), or a mixture containing 4-MMC (1.0 mg/kg or 5.0 mg/kg) + MDMA (3.0 mg/kg) for 7 consecutive days. Following a 10-day drug-free period, rats were given a single intraperitoneal injection of either saline, 4-MMC (1.0 or 5.0 mg/kg), or 3.0 mg/kg MDMA. Activity was recorded for 1 h immediately before and 1 h immediately after injections on days 1, 7, and 17. 4-MMC treatment failed to induce locomotor sensitization, but, when combined with MDMA, sensitization was induced to a greater extent than with MDMA alone. Furthermore, the expression of sensitization to a subsequent challenge dose of MDMA was observed only in animals previously exposed to MDMA or a 5.0 mg/kg 4-MMC + MDMA mixture. In consideration of these findings along with the fact that 4-MMC has similar neurochemical actions to MDMA, further research may be warranted to determine the abuse liability of drug mixtures including 4-MMC and MDMA.

Authors+Show Affiliations

Department of Psychology, Western Michigan University, Michigan, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31268871

Citation

Bullock, Trent A., et al. "Locomotor Sensitization in Male Sprague-Dawley Rats Following Repeated Concurrent Treatment With 4-methylmethcathinone and 3,4-methylenedioxymethamphetamine." Behavioural Pharmacology, vol. 30, no. 7, 2019, pp. 566-573.
Bullock TA, Berquist MD, Baker LE. Locomotor sensitization in male Sprague-Dawley rats following repeated concurrent treatment with 4-methylmethcathinone and 3,4-methylenedioxymethamphetamine. Behav Pharmacol. 2019;30(7):566-573.
Bullock, T. A., Berquist, M. D., & Baker, L. E. (2019). Locomotor sensitization in male Sprague-Dawley rats following repeated concurrent treatment with 4-methylmethcathinone and 3,4-methylenedioxymethamphetamine. Behavioural Pharmacology, 30(7), 566-573. https://doi.org/10.1097/FBP.0000000000000491
Bullock TA, Berquist MD, Baker LE. Locomotor Sensitization in Male Sprague-Dawley Rats Following Repeated Concurrent Treatment With 4-methylmethcathinone and 3,4-methylenedioxymethamphetamine. Behav Pharmacol. 2019;30(7):566-573. PubMed PMID: 31268871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Locomotor sensitization in male Sprague-Dawley rats following repeated concurrent treatment with 4-methylmethcathinone and 3,4-methylenedioxymethamphetamine. AU - Bullock,Trent A, AU - Berquist,Michael D, AU - Baker,Lisa E, PY - 2019/7/4/pubmed PY - 2019/7/4/medline PY - 2019/7/4/entrez SP - 566 EP - 573 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 30 IS - 7 N2 - Recreational abuse of illicit synthetic cathinones is an ongoing public health concern. Recent studies indicate that the methcathinone derivative 4-methylmethcathinone (4-MMC) produces behavioral and neurochemical effects similar to the entactogen 3,4-methylenedioxymethamphetamine (MDMA). Whereas polysubstance abuse is common, most preclinical studies of drug abuse liability only evaluate the effects of single drugs. Utilizing the locomotor sensitization paradigm, the present study assessed the combined locomotor stimulant effects of 4-MMC and MDMA for induction of sensitization following repeated administration and for expression of sensitization to a challenge dose of either substance alone after a 10-day period of drug abstinence. Male Sprague-Dawley rats received once daily intraperitoneal injections of saline, 4-MMC (1.0 mg/kg or 5.0 mg/kg), MDMA (3.0 mg/kg), or a mixture containing 4-MMC (1.0 mg/kg or 5.0 mg/kg) + MDMA (3.0 mg/kg) for 7 consecutive days. Following a 10-day drug-free period, rats were given a single intraperitoneal injection of either saline, 4-MMC (1.0 or 5.0 mg/kg), or 3.0 mg/kg MDMA. Activity was recorded for 1 h immediately before and 1 h immediately after injections on days 1, 7, and 17. 4-MMC treatment failed to induce locomotor sensitization, but, when combined with MDMA, sensitization was induced to a greater extent than with MDMA alone. Furthermore, the expression of sensitization to a subsequent challenge dose of MDMA was observed only in animals previously exposed to MDMA or a 5.0 mg/kg 4-MMC + MDMA mixture. In consideration of these findings along with the fact that 4-MMC has similar neurochemical actions to MDMA, further research may be warranted to determine the abuse liability of drug mixtures including 4-MMC and MDMA. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/31268871/Locomotor_sensitization_in_male_Sprague-Dawley_rats_following_repeated_concurrent_treatment_with_4-methylmethcathinone_and_3,4-methylenedioxymethamphetamine L2 - https://doi.org/10.1097/FBP.0000000000000491 DB - PRIME DP - Unbound Medicine ER -