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Mindfulness-Based Stress Reduction-related changes in posterior cingulate resting brain connectivity.
Soc Cogn Affect Neurosci. 2019 07 31; 14(7):777-787.SC

Abstract

Mindfulness meditation training has been shown to increase resting-state functional connectivity between nodes of the frontoparietal executive control network (dorsolateral prefrontal cortex [DLPFC]) and the default mode network (posterior cingulate cortex [PCC]). We investigated whether these effects generalized to a Mindfulness-Based Stress Reduction (MBSR) course and tested for structural and behaviorally relevant consequences of change in connectivity. Healthy, meditation-naïve adults were randomized to either MBSR (N = 48), an active (N = 47) or waitlist (N = 45) control group. Participants completed behavioral testing, resting-state fMRI scans and diffusion tensor scans at pre-randomization (T1), post-intervention (T2) and ~5.5 months later (T3). We found increased T2-T1 PCC-DLPFC resting connectivity for MBSR relative to control groups. Although these effects did not persist through long-term follow-up (T3-T1), MBSR participants showed a significantly stronger relationship between days of practice (T1 to T3) and increased PCC-DLPFC resting connectivity than participants in the active control group. Increased PCC-DLPFC resting connectivity in MBSR participants was associated with increased microstructural connectivity of a white matter tract connecting these regions and increased self-reported attention. These data show that MBSR increases PCC-DLPFC resting connectivity, which is related to increased practice time, attention and structural connectivity.

Authors+Show Affiliations

Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA. Department of Psychology, University of Wisconsin-Madison, Madison, WI 53703, USA. Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53703, USA.Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA.Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA. Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53703, USA.Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA. Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53703, USA.Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA. Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53703, USA.Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA.Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA. Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53703, USA.Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA. Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53703, USA.Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA. Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53703, USA.Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA. Department of Psychology, University of Wisconsin-Madison, Madison, WI 53703, USA. Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53703, USA. Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53703, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31269203

Citation

Kral, Tammi R A., et al. "Mindfulness-Based Stress Reduction-related Changes in Posterior Cingulate Resting Brain Connectivity." Social Cognitive and Affective Neuroscience, vol. 14, no. 7, 2019, pp. 777-787.
Kral TRA, Imhoff-Smith T, Dean DC, et al. Mindfulness-Based Stress Reduction-related changes in posterior cingulate resting brain connectivity. Soc Cogn Affect Neurosci. 2019;14(7):777-787.
Kral, T. R. A., Imhoff-Smith, T., Dean, D. C., Grupe, D., Adluru, N., Patsenko, E., Mumford, J. A., Goldman, R., Rosenkranz, M. A., & Davidson, R. J. (2019). Mindfulness-Based Stress Reduction-related changes in posterior cingulate resting brain connectivity. Social Cognitive and Affective Neuroscience, 14(7), 777-787. https://doi.org/10.1093/scan/nsz050
Kral TRA, et al. Mindfulness-Based Stress Reduction-related Changes in Posterior Cingulate Resting Brain Connectivity. Soc Cogn Affect Neurosci. 2019 07 31;14(7):777-787. PubMed PMID: 31269203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mindfulness-Based Stress Reduction-related changes in posterior cingulate resting brain connectivity. AU - Kral,Tammi R A, AU - Imhoff-Smith,Ted, AU - Dean,Douglas C, AU - Grupe,Dan, AU - Adluru,Nagesh, AU - Patsenko,Elena, AU - Mumford,Jeanette A, AU - Goldman,Robin, AU - Rosenkranz,Melissa A, AU - Davidson,Richard J, PY - 2018/08/12/received PY - 2019/05/16/revised PY - 2019/06/20/accepted PY - 2019/7/4/pubmed PY - 2020/1/22/medline PY - 2019/7/4/entrez KW - dorsolateral prefrontal cortex KW - mindfulness KW - posterior cingulate KW - resting-state connectivity SP - 777 EP - 787 JF - Social cognitive and affective neuroscience JO - Soc Cogn Affect Neurosci VL - 14 IS - 7 N2 - Mindfulness meditation training has been shown to increase resting-state functional connectivity between nodes of the frontoparietal executive control network (dorsolateral prefrontal cortex [DLPFC]) and the default mode network (posterior cingulate cortex [PCC]). We investigated whether these effects generalized to a Mindfulness-Based Stress Reduction (MBSR) course and tested for structural and behaviorally relevant consequences of change in connectivity. Healthy, meditation-naïve adults were randomized to either MBSR (N = 48), an active (N = 47) or waitlist (N = 45) control group. Participants completed behavioral testing, resting-state fMRI scans and diffusion tensor scans at pre-randomization (T1), post-intervention (T2) and ~5.5 months later (T3). We found increased T2-T1 PCC-DLPFC resting connectivity for MBSR relative to control groups. Although these effects did not persist through long-term follow-up (T3-T1), MBSR participants showed a significantly stronger relationship between days of practice (T1 to T3) and increased PCC-DLPFC resting connectivity than participants in the active control group. Increased PCC-DLPFC resting connectivity in MBSR participants was associated with increased microstructural connectivity of a white matter tract connecting these regions and increased self-reported attention. These data show that MBSR increases PCC-DLPFC resting connectivity, which is related to increased practice time, attention and structural connectivity. SN - 1749-5024 UR - https://www.unboundmedicine.com/medline/citation/31269203/Mindfulness_Based_Stress_Reduction_related_changes_in_posterior_cingulate_resting_brain_connectivity_ L2 - https://academic.oup.com/scan/article-lookup/doi/10.1093/scan/nsz050 DB - PRIME DP - Unbound Medicine ER -