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Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer's and Parkinson's disease models.
Pharmacol Res. 2019 08; 146:104336.PR

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are recognized as the universal neurodegenerative diseases, with the involvement of misfolded proteins pathology, leading to oxidative stress, glial cells activation, neuroinflammation, mitochondrial dysfunction, and cellular apoptosis. Several discoveries indicate that accumulation of pathogenic proteins, i.e. amyloid β (Aβ), the microtubule-binding protein tau, and α-synuclein, are parallel with oxidative stress, neuroinflammation, and mitochondrial dysfunction. Whether the causative factors are misfolded proteins or these pathophysiological changes, leading to neurodegeneration still remain ambiguous. Importantly, directing pharmacological researches towards the prevention of AD and PD seem a promising approach to detect these complicating mechanisms, and provide new insight into therapy for AD and PD patients. Mangiferin (MGF, 2-C-β-D-glucopyranosyl-1, 3, 6, 7-tetrahydroxyxanthone), well-known as a natural product, is detached from multiple plants, including Mangifera indica L. With the structure of C-glycosyl and phenolic moiety, MGF possesses multipotent properties starting from anti-oxidant effects, to the alleviation of mitochondrial dysfunction, neuroinflammation, and cellular apoptosis. In particular, MGF can cross the blood-brain barrier to exert neuronal protection. Different researches implicate that MGF is able to protect the central nervous system from oxidative stress, mitochondrial dysfunction, neuroinflammation, and apoptosis under in vitro and in vivo models. Additional facts support that MGF plays a role in improving the declined memory and cognition of rat models. Taken together, the neuroprotective capacity of MGF may stand out as an agent candidate for AD and PD therapy.

Authors+Show Affiliations

Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China. Electronic address: yzhang@bucm.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

31271846

Citation

Feng, Si-Tong, et al. "Mangiferin: a Multipotent Natural Product Preventing Neurodegeneration in Alzheimer's and Parkinson's Disease Models." Pharmacological Research, vol. 146, 2019, p. 104336.
Feng ST, Wang ZZ, Yuan YH, et al. Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer's and Parkinson's disease models. Pharmacol Res. 2019;146:104336.
Feng, S. T., Wang, Z. Z., Yuan, Y. H., Sun, H. M., Chen, N. H., & Zhang, Y. (2019). Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer's and Parkinson's disease models. Pharmacological Research, 146, 104336. https://doi.org/10.1016/j.phrs.2019.104336
Feng ST, et al. Mangiferin: a Multipotent Natural Product Preventing Neurodegeneration in Alzheimer's and Parkinson's Disease Models. Pharmacol Res. 2019;146:104336. PubMed PMID: 31271846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer's and Parkinson's disease models. AU - Feng,Si-Tong, AU - Wang,Zhen-Zhen, AU - Yuan,Yu-He, AU - Sun,Hong-Mei, AU - Chen,Nai-Hong, AU - Zhang,Yi, Y1 - 2019/07/02/ PY - 2019/03/28/received PY - 2019/06/27/revised PY - 2019/06/28/accepted PY - 2019/7/5/pubmed PY - 2020/5/12/medline PY - 2019/7/5/entrez KW - Alzheimer’s disease KW - Mangiferin KW - Mitochondrial dysfunction KW - Neuroinflammation KW - Oxidative stress KW - Parkinson’s disease SP - 104336 EP - 104336 JF - Pharmacological research JO - Pharmacol Res VL - 146 N2 - Alzheimer's disease (AD) and Parkinson's disease (PD) are recognized as the universal neurodegenerative diseases, with the involvement of misfolded proteins pathology, leading to oxidative stress, glial cells activation, neuroinflammation, mitochondrial dysfunction, and cellular apoptosis. Several discoveries indicate that accumulation of pathogenic proteins, i.e. amyloid β (Aβ), the microtubule-binding protein tau, and α-synuclein, are parallel with oxidative stress, neuroinflammation, and mitochondrial dysfunction. Whether the causative factors are misfolded proteins or these pathophysiological changes, leading to neurodegeneration still remain ambiguous. Importantly, directing pharmacological researches towards the prevention of AD and PD seem a promising approach to detect these complicating mechanisms, and provide new insight into therapy for AD and PD patients. Mangiferin (MGF, 2-C-β-D-glucopyranosyl-1, 3, 6, 7-tetrahydroxyxanthone), well-known as a natural product, is detached from multiple plants, including Mangifera indica L. With the structure of C-glycosyl and phenolic moiety, MGF possesses multipotent properties starting from anti-oxidant effects, to the alleviation of mitochondrial dysfunction, neuroinflammation, and cellular apoptosis. In particular, MGF can cross the blood-brain barrier to exert neuronal protection. Different researches implicate that MGF is able to protect the central nervous system from oxidative stress, mitochondrial dysfunction, neuroinflammation, and apoptosis under in vitro and in vivo models. Additional facts support that MGF plays a role in improving the declined memory and cognition of rat models. Taken together, the neuroprotective capacity of MGF may stand out as an agent candidate for AD and PD therapy. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/31271846/Mangiferin:_A_multipotent_natural_product_preventing_neurodegeneration_in_Alzheimer's_and_Parkinson's_disease_models_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(19)30436-0 DB - PRIME DP - Unbound Medicine ER -