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Acute psychosis in glycogen storage disease: a rare but severe complication.
BMJ Case Rep 2019; 12(7)BC

Abstract

Glycogen storage disease type 1 (GSD-1) is a group of inherited metabolic disorders characterised by the inability to use intracellular glucose stores. It is associated with a high risk of hypoglycaemia, as well as long-term complications including growth retardation, hepatocellular adenomas, renal disease, hypertriglyceridaemia and hyperuricaemia. Treatment involves slow absorption carbohydrates, for example, cornstarch. We present a case of acute psychosis in a patient with GSD-1a. This was initially attributed to his opiate use. Later in his management an MRI scan of his head was performed which revealed regions of brain atrophy following significant hypoglycaemic insult, thus identifying an organic cause of his psychosis. This case presents a rare complication of glycogen storage disease: organic psychosis attributable to cortical atrophy from profound hypoglycaemic insult. It emphasises the importance of investigating organic causes of psychiatric symptoms.

Authors+Show Affiliations

College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.Institute of Metabolism and Systems Research, University of BIrmingham, Birmingham, UK.Department of Psychiatry, Queen Elizabeth Hospital, Birmingham, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31272990

Citation

Dunne, Thomas Frederick, et al. "Acute Psychosis in Glycogen Storage Disease: a Rare but Severe Complication." BMJ Case Reports, vol. 12, no. 7, 2019.
Dunne TF, Geberhiwot T, Jones R. Acute psychosis in glycogen storage disease: a rare but severe complication. BMJ Case Rep. 2019;12(7).
Dunne, T. F., Geberhiwot, T., & Jones, R. (2019). Acute psychosis in glycogen storage disease: a rare but severe complication. BMJ Case Reports, 12(7), doi:10.1136/bcr-2017-222307.
Dunne TF, Geberhiwot T, Jones R. Acute Psychosis in Glycogen Storage Disease: a Rare but Severe Complication. BMJ Case Rep. 2019 Jul 4;12(7) PubMed PMID: 31272990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute psychosis in glycogen storage disease: a rare but severe complication. AU - Dunne,Thomas Frederick, AU - Geberhiwot,Tarekegn, AU - Jones,Rowena, Y1 - 2019/07/04/ PY - 2019/7/6/entrez KW - metabolic disorders KW - neurological injury KW - psychotic disorders (incl schizophrenia) JF - BMJ case reports JO - BMJ Case Rep VL - 12 IS - 7 N2 - Glycogen storage disease type 1 (GSD-1) is a group of inherited metabolic disorders characterised by the inability to use intracellular glucose stores. It is associated with a high risk of hypoglycaemia, as well as long-term complications including growth retardation, hepatocellular adenomas, renal disease, hypertriglyceridaemia and hyperuricaemia. Treatment involves slow absorption carbohydrates, for example, cornstarch. We present a case of acute psychosis in a patient with GSD-1a. This was initially attributed to his opiate use. Later in his management an MRI scan of his head was performed which revealed regions of brain atrophy following significant hypoglycaemic insult, thus identifying an organic cause of his psychosis. This case presents a rare complication of glycogen storage disease: organic psychosis attributable to cortical atrophy from profound hypoglycaemic insult. It emphasises the importance of investigating organic causes of psychiatric symptoms. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/31272990/Acute_psychosis_in_glycogen_storage_disease:_a_rare_but_severe_complication L2 - http://casereports.bmj.com/cgi/pmidlookup?view=long&pmid=31272990 DB - PRIME DP - Unbound Medicine ER -