Tags

Type your tag names separated by a space and hit enter

Retinal microvasculature: population epidemiology and concordance in Australian children aged 11-12 years and their parents.
BMJ Open 2019; 9(Suppl 3):44-52BO

Abstract

OBJECTIVES

To describe distributions and concordance of retinal microvasculature measurements in a population-based sample of Australian parent-child dyads at child age 11-12 years.

DESIGN

Cross-sectional Child Health CheckPoint study, between waves 6 and 7 of the national population-based Longitudinal Study of Australian Children (LSAC).

SETTING

Assessment centres in seven Australian cities, February 2015-March 2016.

PARTICIPANTS

Of the 1874 participating families, 1288 children (51% girls) and 1264 parents (87% mothers, mean age 43.7) were analysed. Diabetic participants and non-biological pairs were excluded from concordance analyses.

OUTCOME MEASURES

Retinal photographs were taken by non-mydriatic fundus camera. Trained graders scored vascular calibre using semi-automated software, yielding estimates of central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) and arteriolar-venular ratio (AVR). Pearson's correlation coefficients and multivariable linear regression models assessed parent-child concordance. Survey weights and methods accounted for LSAC's complex sampling, stratification and clustering within postcodes.

RESULTS

Mean (SD) of CRAE and CRVE were larger in children (159.5 (11.8) and 231.1 (16.5) μm, respectively) than parents (151.5 (14.0) and 220.6 (19.0) μm), yielding similar AVR (children 0.69 (0.05), parents 0.69 (0.06)). Correlation coefficients for parent-child pairs were 0.22 (95% CI 0.16 to 0.27) for CRAE, 0.23 (95% CI 0.17 to 0.28) for CRVE and 0.18 (95% CI 0.13 to 0.24) for AVR. Mother-child and father-child values were similar (0.20 and 0.32 for CRAE, 0.22 and 0.29 for CRVE, respectively). Relationships attenuated slightly on adjustment for age, sex, blood pressure, diabetes and body mass index. Percentiles and concordance are presented for the whole sample and by sex.

CONCLUSIONS

Arteriolar and venular calibre were similar to previously documented measures in midlife adult and late childhood populations. Population parent-child concordance values align with moderate polygenic heritability reported in smaller studies.

Authors+Show Affiliations

Murdoch Children's Research Institute, Parkville, Victoria, Australia.Murdoch Children's Research Institute, Parkville, Victoria, Australia. Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.Murdoch Children's Research Institute, Parkville, Victoria, Australia. Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia. School of Psychology, Deakin University, Burwood, Victoria, Australia.Murdoch Children's Research Institute, Parkville, Victoria, Australia. Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.Centre for Eye Research Australia, The University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.Murdoch Children's Research Institute, Parkville, Victoria, Australia. Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia. Department of Paediatrics, Monash University, Melbourne, Victoria, Australia.Centre for Eye Research Australia, The University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.Murdoch Children's Research Institute, Parkville, Victoria, Australia. Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia. Department of Paediatrics and The Liggins Institute, The University of Auckland, Auckland, New Zealand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31273015

Citation

Dascalu, Julian, et al. "Retinal Microvasculature: Population Epidemiology and Concordance in Australian Children Aged 11-12 Years and Their Parents." BMJ Open, vol. 9, no. Suppl 3, 2019, pp. 44-52.
Dascalu J, Liu M, Lycett K, et al. Retinal microvasculature: population epidemiology and concordance in Australian children aged 11-12 years and their parents. BMJ Open. 2019;9(Suppl 3):44-52.
Dascalu, J., Liu, M., Lycett, K., Grobler, A. C., He, M., Burgner, D. P., ... Wake, M. (2019). Retinal microvasculature: population epidemiology and concordance in Australian children aged 11-12 years and their parents. BMJ Open, 9(Suppl 3), pp. 44-52. doi:10.1136/bmjopen-2018-022399.
Dascalu J, et al. Retinal Microvasculature: Population Epidemiology and Concordance in Australian Children Aged 11-12 Years and Their Parents. BMJ Open. 2019 Jul 4;9(Suppl 3):44-52. PubMed PMID: 31273015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal microvasculature: population epidemiology and concordance in Australian children aged 11-12 years and their parents. AU - Dascalu,Julian, AU - Liu,Mengjiao, AU - Lycett,Kate, AU - Grobler,Anneke C, AU - He,Mingguang, AU - Burgner,David P, AU - Wong,Tien Yin, AU - Wake,Melissa, Y1 - 2019/07/04/ PY - 2019/7/6/entrez PY - 2019/7/6/pubmed PY - 2019/7/6/medline KW - children KW - correlation studies KW - cross-sectional studies KW - epidemiologic studies KW - epidemiology KW - inheritance patterns KW - parents KW - reference values KW - retinal vessel calibre KW - retinal vessels SP - 44 EP - 52 JF - BMJ open JO - BMJ Open VL - 9 IS - Suppl 3 N2 - OBJECTIVES: To describe distributions and concordance of retinal microvasculature measurements in a population-based sample of Australian parent-child dyads at child age 11-12 years. DESIGN: Cross-sectional Child Health CheckPoint study, between waves 6 and 7 of the national population-based Longitudinal Study of Australian Children (LSAC). SETTING: Assessment centres in seven Australian cities, February 2015-March 2016. PARTICIPANTS: Of the 1874 participating families, 1288 children (51% girls) and 1264 parents (87% mothers, mean age 43.7) were analysed. Diabetic participants and non-biological pairs were excluded from concordance analyses. OUTCOME MEASURES: Retinal photographs were taken by non-mydriatic fundus camera. Trained graders scored vascular calibre using semi-automated software, yielding estimates of central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) and arteriolar-venular ratio (AVR). Pearson's correlation coefficients and multivariable linear regression models assessed parent-child concordance. Survey weights and methods accounted for LSAC's complex sampling, stratification and clustering within postcodes. RESULTS: Mean (SD) of CRAE and CRVE were larger in children (159.5 (11.8) and 231.1 (16.5) μm, respectively) than parents (151.5 (14.0) and 220.6 (19.0) μm), yielding similar AVR (children 0.69 (0.05), parents 0.69 (0.06)). Correlation coefficients for parent-child pairs were 0.22 (95% CI 0.16 to 0.27) for CRAE, 0.23 (95% CI 0.17 to 0.28) for CRVE and 0.18 (95% CI 0.13 to 0.24) for AVR. Mother-child and father-child values were similar (0.20 and 0.32 for CRAE, 0.22 and 0.29 for CRVE, respectively). Relationships attenuated slightly on adjustment for age, sex, blood pressure, diabetes and body mass index. Percentiles and concordance are presented for the whole sample and by sex. CONCLUSIONS: Arteriolar and venular calibre were similar to previously documented measures in midlife adult and late childhood populations. Population parent-child concordance values align with moderate polygenic heritability reported in smaller studies. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/31273015/Retinal_microvasculature:_population_epidemiology_and_concordance_in_Australian_children_aged_11-12_years_and_their_parents L2 - http://bmjopen.bmj.com/cgi/pmidlookup?view=long&pmid=31273015 DB - PRIME DP - Unbound Medicine ER -