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Analysis of Wild Raspberries (Rubus idaeus L.): Optimization of the Ultrasonic-Assisted Extraction of Phenolics and a New Insight in Phenolics Bioaccessibility.
Plant Foods Hum Nutr. 2019 Sep; 74(3):399-404.PF

Abstract

A simple and efficient ultrasonic-assisted extraction (UAE) technique was developed in order to find optimal conditions for the extraction of total phenolic compounds, flavonoids and anthocyanins in wild raspberry (Rubus idaeus L.) fruits. Several extraction variables, including methanol composition (v/v, %), solid-solvent ratio (g/mL), time (min) and extraction temperature (°C) were optimized using response surface methodology (RSM). Under optimal conditions for extraction, the total phenolics were found in the concentration of 383 mg GAE/100 g of fresh fruit weight, while HPLC-PDA analysis of the optimized extract showed the presence of cyanidin-3-glucoside, cyanidin-3-sophoroside, catechin, gallic and ellagic acid. The experimental values of DPPH and ABTS radical scavenging activities were 29.0 and 39.5 μmol Trolox/g of fresh fruit weight, respectively. In vitro simulated gastrointestinal digestion showed great raspberry phenolics stability. Our study assessed the bioaccessible phenolics in wild raspberry fruits and showed optimal conditions for the effective extraction of bioactive compounds for their analysis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mihailović NR
Faculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, Kragujevac, 34000, Serbia.
Mihailović VB
Faculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, Kragujevac, 34000, Serbia.
Ćirić AR
Faculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, Kragujevac, 34000, Serbia.
Srećković NZ
Faculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, Kragujevac, 34000, Serbia.
Cvijović MR
Faculty of Medicine, Institute for Microbiology and Immunology, University of Belgrade, Dr Subotića 1, Belgrade, 11000, Serbia.
Joksović LG
Faculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, Kragujevac, 34000, Serbia. ljubinka@kg.ac.rs.

MeSH

AnthocyaninsChromatography, High Pressure LiquidFlavonoidsFruitPhenolsPhytochemicalsPlant ExtractsRubusSonication

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31273641

Citation

Mihailović, Nevena R., et al. "Analysis of Wild Raspberries (Rubus Idaeus L.): Optimization of the Ultrasonic-Assisted Extraction of Phenolics and a New Insight in Phenolics Bioaccessibility." Plant Foods for Human Nutrition (Dordrecht, Netherlands), vol. 74, no. 3, 2019, pp. 399-404.
Mihailović NR, Mihailović VB, Ćirić AR, et al. Analysis of Wild Raspberries (Rubus idaeus L.): Optimization of the Ultrasonic-Assisted Extraction of Phenolics and a New Insight in Phenolics Bioaccessibility. Plant Foods Hum Nutr. 2019;74(3):399-404.
Mihailović, N. R., Mihailović, V. B., Ćirić, A. R., Srećković, N. Z., Cvijović, M. R., & Joksović, L. G. (2019). Analysis of Wild Raspberries (Rubus idaeus L.): Optimization of the Ultrasonic-Assisted Extraction of Phenolics and a New Insight in Phenolics Bioaccessibility. Plant Foods for Human Nutrition (Dordrecht, Netherlands), 74(3), 399-404. https://doi.org/10.1007/s11130-019-00756-4
Mihailović NR, et al. Analysis of Wild Raspberries (Rubus Idaeus L.): Optimization of the Ultrasonic-Assisted Extraction of Phenolics and a New Insight in Phenolics Bioaccessibility. Plant Foods Hum Nutr. 2019;74(3):399-404. PubMed PMID: 31273641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of Wild Raspberries (Rubus idaeus L.): Optimization of the Ultrasonic-Assisted Extraction of Phenolics and a New Insight in Phenolics Bioaccessibility. AU - Mihailović,Nevena R, AU - Mihailović,Vladimir B, AU - Ćirić,Andrija R, AU - Srećković,Nikola Z, AU - Cvijović,Mirjana R, AU - Joksović,Ljubinka G, PY - 2019/7/6/pubmed PY - 2019/8/23/medline PY - 2019/7/6/entrez KW - Antioxidant activity KW - Cyanidin-3-glucoside KW - Extraction KW - HPLC-PDA KW - In vitro digestion KW - Rubus idaeus L. SP - 399 EP - 404 JF - Plant foods for human nutrition (Dordrecht, Netherlands) JO - Plant Foods Hum Nutr VL - 74 IS - 3 N2 - A simple and efficient ultrasonic-assisted extraction (UAE) technique was developed in order to find optimal conditions for the extraction of total phenolic compounds, flavonoids and anthocyanins in wild raspberry (Rubus idaeus L.) fruits. Several extraction variables, including methanol composition (v/v, %), solid-solvent ratio (g/mL), time (min) and extraction temperature (°C) were optimized using response surface methodology (RSM). Under optimal conditions for extraction, the total phenolics were found in the concentration of 383 mg GAE/100 g of fresh fruit weight, while HPLC-PDA analysis of the optimized extract showed the presence of cyanidin-3-glucoside, cyanidin-3-sophoroside, catechin, gallic and ellagic acid. The experimental values of DPPH and ABTS radical scavenging activities were 29.0 and 39.5 μmol Trolox/g of fresh fruit weight, respectively. In vitro simulated gastrointestinal digestion showed great raspberry phenolics stability. Our study assessed the bioaccessible phenolics in wild raspberry fruits and showed optimal conditions for the effective extraction of bioactive compounds for their analysis. SN - 1573-9104 UR - https://www.unboundmedicine.com/medline/citation/31273641/Analysis_of_Wild_Raspberries__Rubus_idaeus_L__:_Optimization_of_the_Ultrasonic_Assisted_Extraction_of_Phenolics_and_a_New_Insight_in_Phenolics_Bioaccessibility_ DB - PRIME DP - Unbound Medicine ER -
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