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Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia.
J Zhejiang Univ Sci B 2019 Aug.; 20(8):687-692JZ

Abstract

The objective of this study was to assess the angiogenic potential expressed as a quotient of vascular endothelial growth factor A (VEGF-A), as an indicator of proangiogenic activity, and the circulating receptors (soluble VEGF receptor protein R1 (sVEGFR-1) and sVEGFR-2), as indicators of the effect of angiogenic inhibition, depending on the concentrations of matrix metalloproteinase 2 (MMP-2) and MMP-9 and their tissue inhibitor 1 (TIMP-1) and TIMP-2 in the plasma of patients with lower extremity artery disease (LEAD). These blood parameters in patients with intermittent claudication (IC) and critical limb ischemia (CLI) were compared for select clinical and biochemical features. Stimulation of angiogenesis in the plasma of individuals with LEAD was evident as indicated by the significant increase in VEGF-A concentration along with reduced inhibition depending on circulating receptors sVEGFR-1 and sVEGFR-2. Critical ischemia was associated with higher VEGF-A, MMP-9, TIMP-1, and TIMP-2 concentrations than in the case of IC.

Authors+Show Affiliations

Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz PL 85-094, Poland. Clinic of Vascular and Internal Medicine, Dr Jan Biziel University Hospital No. 2 in Bydgoszcz, Bydgoszcz PL 85-168, Poland.Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz PL 85-094, Poland.Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz PL 85-094, Poland.Clinic of Vascular and Internal Medicine, Dr Jan Biziel University Hospital No. 2 in Bydgoszcz, Bydgoszcz PL 85-168, Poland.Clinic of Vascular and Internal Medicine, Dr Jan Biziel University Hospital No. 2 in Bydgoszcz, Bydgoszcz PL 85-168, Poland. Department of Vascular and Internal Medicine, Faculty of Health Sciences, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz PL 85-168, Poland.Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz PL 85-094, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31273966

Citation

Wieczór, Radosław, et al. "Coexistence of Proangiogenic Potential and Increased MMP-9, TIMP-1, and TIMP-2 Levels in the Plasma of Patients With Critical Limb Ischemia." Journal of Zhejiang University. Science. B, vol. 20, no. 8, 2019, pp. 687-692.
Wieczór R, Wieczór AM, Kulwas A, et al. Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia. J Zhejiang Univ Sci B. 2019;20(8):687-692.
Wieczór, R., Wieczór, A. M., Kulwas, A., Pulkowski, G., Budzyński, J., & Rość, D. (2019). Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia. Journal of Zhejiang University. Science. B, 20(8), pp. 687-692. doi:10.1631/jzus.B1800373.
Wieczór R, et al. Coexistence of Proangiogenic Potential and Increased MMP-9, TIMP-1, and TIMP-2 Levels in the Plasma of Patients With Critical Limb Ischemia. J Zhejiang Univ Sci B. 2019;20(8):687-692. PubMed PMID: 31273966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia. AU - Wieczór,Radosław, AU - Wieczór,Anna Maria, AU - Kulwas,Arleta, AU - Pulkowski,Grzegorz, AU - Budzyński,Jacek, AU - Rość,Danuta, PY - 2019/7/6/entrez PY - 2019/7/6/pubmed PY - 2019/7/6/medline KW - Intermittent claudication; Critical limb ischemia; Vascular endothelial growth factor; Metalloproteinase SP - 687 EP - 692 JF - Journal of Zhejiang University. Science. B JO - J Zhejiang Univ Sci B VL - 20 IS - 8 N2 - The objective of this study was to assess the angiogenic potential expressed as a quotient of vascular endothelial growth factor A (VEGF-A), as an indicator of proangiogenic activity, and the circulating receptors (soluble VEGF receptor protein R1 (sVEGFR-1) and sVEGFR-2), as indicators of the effect of angiogenic inhibition, depending on the concentrations of matrix metalloproteinase 2 (MMP-2) and MMP-9 and their tissue inhibitor 1 (TIMP-1) and TIMP-2 in the plasma of patients with lower extremity artery disease (LEAD). These blood parameters in patients with intermittent claudication (IC) and critical limb ischemia (CLI) were compared for select clinical and biochemical features. Stimulation of angiogenesis in the plasma of individuals with LEAD was evident as indicated by the significant increase in VEGF-A concentration along with reduced inhibition depending on circulating receptors sVEGFR-1 and sVEGFR-2. Critical ischemia was associated with higher VEGF-A, MMP-9, TIMP-1, and TIMP-2 concentrations than in the case of IC. SN - 1862-1783 UR - https://www.unboundmedicine.com/medline/citation/31273966/Coexistence_of_proangiogenic_potential_and_increased_MMP-9,_TIMP-1,_and_TIMP-2_levels_in_the_plasma_of_patients_with_critical_limb_ischemia L2 - http://www.jzus.zju.edu.cn/article.php?doi=10.1631/jzus.B1800373 DB - PRIME DP - Unbound Medicine ER -