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Necrotizing Mucormycosis of Wounds Following Combat Injuries, Natural Disasters, Burns, and Other Trauma.
J Fungi (Basel) 2019; 5(3)JF

Abstract

Necrotizing mucormycosis is a devastating complication of wounds incurred in the setting of military (combat) injuries, natural disasters, burns, or other civilian trauma. Apophysomyces species, Saksenaea species and Lichtheimia (formerly Absidia) species, although uncommon as causes of sinopulmonary mucormycosis, are relatively frequent agents of trauma-related mucormycosis. The pathogenesis of these infections likely involves a complex interaction among organism, impaired innate host defenses, and biofilms related to traumatically implanted foreign materials. Effective management depends upon timely diagnosis, thorough surgical debridement, and early initiation of antifungal therapy.

Authors+Show Affiliations

Departments of Medicine, Pediatrics, and Microbiology & Immunology; Weill Cornell Medicine of Cornell University and New York Presbyterian Hospital, New York, NY 10065, USA. thw2003@med.cornell.edu.Division of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.Departments of Medicine, Weill Cornell Medicine of Cornell University, New York, NY 10065, USA.Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31277364

Citation

Walsh, Thomas J., et al. "Necrotizing Mucormycosis of Wounds Following Combat Injuries, Natural Disasters, Burns, and Other Trauma." Journal of Fungi (Basel, Switzerland), vol. 5, no. 3, 2019.
Walsh TJ, Hospenthal DR, Petraitis V, et al. Necrotizing Mucormycosis of Wounds Following Combat Injuries, Natural Disasters, Burns, and Other Trauma. J Fungi (Basel). 2019;5(3).
Walsh, T. J., Hospenthal, D. R., Petraitis, V., & Kontoyiannis, D. P. (2019). Necrotizing Mucormycosis of Wounds Following Combat Injuries, Natural Disasters, Burns, and Other Trauma. Journal of Fungi (Basel, Switzerland), 5(3), doi:10.3390/jof5030057.
Walsh TJ, et al. Necrotizing Mucormycosis of Wounds Following Combat Injuries, Natural Disasters, Burns, and Other Trauma. J Fungi (Basel). 2019 Jul 4;5(3) PubMed PMID: 31277364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrotizing Mucormycosis of Wounds Following Combat Injuries, Natural Disasters, Burns, and Other Trauma. AU - Walsh,Thomas J, AU - Hospenthal,Duane R, AU - Petraitis,Vidmantas, AU - Kontoyiannis,Dimitrios P, Y1 - 2019/07/04/ PY - 2019/04/01/received PY - 2019/06/28/revised PY - 2019/07/01/accepted PY - 2019/7/7/entrez KW - antifungal therapy KW - mucormycosis JF - Journal of fungi (Basel, Switzerland) JO - J Fungi (Basel) VL - 5 IS - 3 N2 - Necrotizing mucormycosis is a devastating complication of wounds incurred in the setting of military (combat) injuries, natural disasters, burns, or other civilian trauma. Apophysomyces species, Saksenaea species and Lichtheimia (formerly Absidia) species, although uncommon as causes of sinopulmonary mucormycosis, are relatively frequent agents of trauma-related mucormycosis. The pathogenesis of these infections likely involves a complex interaction among organism, impaired innate host defenses, and biofilms related to traumatically implanted foreign materials. Effective management depends upon timely diagnosis, thorough surgical debridement, and early initiation of antifungal therapy. SN - 2309-608X UR - https://www.unboundmedicine.com/medline/citation/31277364/Necrotizing_Mucormycosis_of_Wounds_Following_Combat_Injuries,_Natural_Disasters,_Burns,_and_Other_Trauma L2 - http://www.mdpi.com/resolver?pii=jof5030057 DB - PRIME DP - Unbound Medicine ER -