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Simulating vascular leakage on optical coherence tomography angiography using an overlay technique with corresponding thickness maps.

Abstract

BACKGROUND

To demonstrate a technique for using optical coherence tomography angiography (OCTA) to simulate leakage in eyes with diabetic macular oedema and determine the sensitivity and positive predictive value of detecting leaking microvasculature on OCTA using fluorescein angiography (FA) as the comparative norm.

METHODS

6×6 mm OCT angiograms were overlaid with the corresponding OCT thickness maps. Microvascular abnormalities on the OCT angiogram underlying areas of thickening on the OCT thickness map were assumed to be leaking. Two independent readers blindly read the OCTA overlay images then the FA images cropped to the same approximate region to delineate areas of leaking microvasculature. The results were compared to determine the sensitivity and positive predictive value of OCTA for detection of leaking vessels.

RESULTS

28 eyes of 19 diabetic patients were included. Each eye demonstrated an average of seven leaking microvascular abnormalities on the OCTA images and 22 leaking abnormalities on the FA images. Sensitivity of leaking microvasculature detection by OCTA was 26.1% and positive predictive value was 68.4%. The correlation coefficient of the two readers' detection of leaking microvasculature was 0.605 for OCTA reads compared with 0.916 for FA.

CONCLUSION

OCTA as a whole can be used to simulate leakage, but currently, sensitivity of the technique is low. Further understanding of the OCTA technology may yield novel means of detecting retinal pathology.

Authors+Show Affiliations

Ophthalmology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.Ophthalmology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.Ophthalmology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.Retina, Illinois Eye and Ear Infirmary, Chicago, Illinois, USA.Ophthalmology, University of Illinois, Chicago, Illinois, USA.UIC Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, Illinois, USA wmieler@uic.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31278146

Citation

de Carlo, Talisa E., et al. "Simulating Vascular Leakage On Optical Coherence Tomography Angiography Using an Overlay Technique With Corresponding Thickness Maps." The British Journal of Ophthalmology, 2019.
de Carlo TE, Zahid S, Bohm KJ, et al. Simulating vascular leakage on optical coherence tomography angiography using an overlay technique with corresponding thickness maps. Br J Ophthalmol. 2019.
de Carlo, T. E., Zahid, S., Bohm, K. J., Chan, R. V. P., Lim, J. I., & Mieler, W. F. (2019). Simulating vascular leakage on optical coherence tomography angiography using an overlay technique with corresponding thickness maps. The British Journal of Ophthalmology, doi:10.1136/bjophthalmol-2019-313976.
de Carlo TE, et al. Simulating Vascular Leakage On Optical Coherence Tomography Angiography Using an Overlay Technique With Corresponding Thickness Maps. Br J Ophthalmol. 2019 Jul 5; PubMed PMID: 31278146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simulating vascular leakage on optical coherence tomography angiography using an overlay technique with corresponding thickness maps. AU - de Carlo,Talisa E, AU - Zahid,Sarwar, AU - Bohm,Kelley J, AU - Chan,R V Paul, AU - Lim,Jennifer I, AU - Mieler,William F, Y1 - 2019/07/05/ PY - 2019/01/24/received PY - 2019/06/17/revised PY - 2019/06/26/accepted PY - 2019/7/7/entrez KW - diagnostic tests/investigation KW - imaging KW - macula KW - retina JF - The British journal of ophthalmology JO - Br J Ophthalmol N2 - BACKGROUND: To demonstrate a technique for using optical coherence tomography angiography (OCTA) to simulate leakage in eyes with diabetic macular oedema and determine the sensitivity and positive predictive value of detecting leaking microvasculature on OCTA using fluorescein angiography (FA) as the comparative norm. METHODS: 6×6 mm OCT angiograms were overlaid with the corresponding OCT thickness maps. Microvascular abnormalities on the OCT angiogram underlying areas of thickening on the OCT thickness map were assumed to be leaking. Two independent readers blindly read the OCTA overlay images then the FA images cropped to the same approximate region to delineate areas of leaking microvasculature. The results were compared to determine the sensitivity and positive predictive value of OCTA for detection of leaking vessels. RESULTS: 28 eyes of 19 diabetic patients were included. Each eye demonstrated an average of seven leaking microvascular abnormalities on the OCTA images and 22 leaking abnormalities on the FA images. Sensitivity of leaking microvasculature detection by OCTA was 26.1% and positive predictive value was 68.4%. The correlation coefficient of the two readers' detection of leaking microvasculature was 0.605 for OCTA reads compared with 0.916 for FA. CONCLUSION: OCTA as a whole can be used to simulate leakage, but currently, sensitivity of the technique is low. Further understanding of the OCTA technology may yield novel means of detecting retinal pathology. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/31278146/Simulating_vascular_leakage_on_optical_coherence_tomography_angiography_using_an_overlay_technique_with_corresponding_thickness_maps L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=31278146 DB - PRIME DP - Unbound Medicine ER -