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Spatio-temporal control on the delivery of triamcinolone acetonide using polymeric nanoparticles reduces steroid induced cataract.
Int J Pharm 2019; 568:118474IJ

Abstract

Development of topically administered drug delivery systems for the treatment of ocular diseases have majorly focused on enhancing bioavailability of drugs in the ocular tissues. However, control of spatial distribution of topically administered drugs so as to restrict/avoid drug bioavailability at sensitive ocular tissues that are prone to drug induced adverse effects has not been explored. In this study, we aimed to reduce the bioavailability of topically administered corticosteroid, triamcinolone acetonide (TA) in lens via controlled spatial distribution in order to minimize TA induced posterior subcapsular cataract (PSC). For this, a negatively charged polymeric core-shell nanoparticulate drug delivery system composed of polycaprolactone (PCL) core and pluronic® F-68 (PF68) shell was fabricated. For in vivo studies, coumarin-6 (COU) loaded nanoparticles (NPs) were fabricated and studied for their biodistribution after topical administration in mice eyes and compared with free COU biodistribution. The administered COU loaded NPs differentially distributed in mice eyes and showed lower bioavailability in lens compared to free COU. Further, in vivo efficacy of the delivery system for its ability to minimize the rate of PSC progression was evaluated in diabetic rats. The results demonstrated that TA loaded PCL-PF68 NPs decreased PSC progression compared to free TA when administered topically.

Authors+Show Affiliations

Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, India.Biochemistry Division, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500007, India.Biochemistry Division, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500007, India.Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, India. Electronic address: dsk@iitk.ac.in.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31279055

Citation

Srinivasarao, Dadi A., et al. "Spatio-temporal Control On the Delivery of Triamcinolone Acetonide Using Polymeric Nanoparticles Reduces Steroid Induced Cataract." International Journal of Pharmaceutics, vol. 568, 2019, p. 118474.
Srinivasarao DA, Reddy SS, Reddy GB, et al. Spatio-temporal control on the delivery of triamcinolone acetonide using polymeric nanoparticles reduces steroid induced cataract. Int J Pharm. 2019;568:118474.
Srinivasarao, D. A., Reddy, S. S., Reddy, G. B., & Katti, D. S. (2019). Spatio-temporal control on the delivery of triamcinolone acetonide using polymeric nanoparticles reduces steroid induced cataract. International Journal of Pharmaceutics, 568, p. 118474. doi:10.1016/j.ijpharm.2019.118474.
Srinivasarao DA, et al. Spatio-temporal Control On the Delivery of Triamcinolone Acetonide Using Polymeric Nanoparticles Reduces Steroid Induced Cataract. Int J Pharm. 2019 Jul 3;568:118474. PubMed PMID: 31279055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spatio-temporal control on the delivery of triamcinolone acetonide using polymeric nanoparticles reduces steroid induced cataract. AU - Srinivasarao,Dadi A, AU - Reddy,S Sreenivasa, AU - Reddy,G Bhanuprakash, AU - Katti,Dhirendra S, Y1 - 2019/07/03/ PY - 2019/04/15/received PY - 2019/06/21/revised PY - 2019/06/25/accepted PY - 2019/7/7/pubmed PY - 2019/7/7/medline PY - 2019/7/7/entrez KW - Eye KW - Lens KW - Ocular biodistribution KW - PCL-PF68 core-shell nanoparticles KW - Posterior subcapsular cataract KW - Triamcinolone acetonide SP - 118474 EP - 118474 JF - International journal of pharmaceutics JO - Int J Pharm VL - 568 N2 - Development of topically administered drug delivery systems for the treatment of ocular diseases have majorly focused on enhancing bioavailability of drugs in the ocular tissues. However, control of spatial distribution of topically administered drugs so as to restrict/avoid drug bioavailability at sensitive ocular tissues that are prone to drug induced adverse effects has not been explored. In this study, we aimed to reduce the bioavailability of topically administered corticosteroid, triamcinolone acetonide (TA) in lens via controlled spatial distribution in order to minimize TA induced posterior subcapsular cataract (PSC). For this, a negatively charged polymeric core-shell nanoparticulate drug delivery system composed of polycaprolactone (PCL) core and pluronic® F-68 (PF68) shell was fabricated. For in vivo studies, coumarin-6 (COU) loaded nanoparticles (NPs) were fabricated and studied for their biodistribution after topical administration in mice eyes and compared with free COU biodistribution. The administered COU loaded NPs differentially distributed in mice eyes and showed lower bioavailability in lens compared to free COU. Further, in vivo efficacy of the delivery system for its ability to minimize the rate of PSC progression was evaluated in diabetic rats. The results demonstrated that TA loaded PCL-PF68 NPs decreased PSC progression compared to free TA when administered topically. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/31279055/Spatio-temporal_control_on_the_delivery_of_triamcinolone_acetonide_using_polymeric_nanoparticles_reduces_steroid_induced_cataract L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(19)30516-2 DB - PRIME DP - Unbound Medicine ER -