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Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans.
Oxid Med Cell Longev 2019; 2019:9012396OM

Abstract

Anacardium occidentale (AO) contains a number of polyphenolic secondary metabolites with antioxidant activity. The objectives of this study were aimed at investigating the roles of AO leaf extracts in antioxidative stress and longevity, as well as their underlying mechanisms, in the Caenorhabditis elegans (C. elegans) model. AO extracts mediated the survival rate of nematodes under oxidative stress by attenuating intracellular reactive oxygen species (ROS) via the DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. AO extracts stimulated the expression of stress response genes including SOD-3 and GST-4. Moreover, AO extracts exhibited antiaging activities and enhanced longevity. We observed improved pharyngeal pumping function, attenuation of pigment accumulation (lipofuscin), and an increased lifespan of the worms. Collectively, our results demonstrated that AO extracts exerted both oxidative stress resistance and antiaging properties in the C. elegans model and may lead to new agents to benefit humans in the near future.

Authors+Show Affiliations

Graduate Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. Age-Related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.Graduate Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. Age-Related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. Department of Biotechnology, School of Environmental and Chemical Engineering, Dalian Jiaotong University, Dalian 116028, China.Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.Graduate Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Age-Related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31281595

Citation

Duangjan, Chatrawee, et al. "Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts From Anacardium Occidentale L. in Caenorhabditis Elegans." Oxidative Medicine and Cellular Longevity, vol. 2019, 2019, p. 9012396.
Duangjan C, Rangsinth P, Gu X, et al. Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev. 2019;2019:9012396.
Duangjan, C., Rangsinth, P., Gu, X., Wink, M., & Tencomnao, T. (2019). Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity, 2019, p. 9012396. doi:10.1155/2019/9012396.
Duangjan C, et al. Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts From Anacardium Occidentale L. in Caenorhabditis Elegans. Oxid Med Cell Longev. 2019;2019:9012396. PubMed PMID: 31281595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. AU - Duangjan,Chatrawee, AU - Rangsinth,Panthakarn, AU - Gu,Xiaojie, AU - Wink,Michael, AU - Tencomnao,Tewin, Y1 - 2019/06/02/ PY - 2018/10/25/received PY - 2019/02/01/revised PY - 2019/03/11/accepted PY - 2019/7/9/entrez PY - 2019/7/10/pubmed PY - 2019/7/10/medline SP - 9012396 EP - 9012396 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2019 N2 - Anacardium occidentale (AO) contains a number of polyphenolic secondary metabolites with antioxidant activity. The objectives of this study were aimed at investigating the roles of AO leaf extracts in antioxidative stress and longevity, as well as their underlying mechanisms, in the Caenorhabditis elegans (C. elegans) model. AO extracts mediated the survival rate of nematodes under oxidative stress by attenuating intracellular reactive oxygen species (ROS) via the DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. AO extracts stimulated the expression of stress response genes including SOD-3 and GST-4. Moreover, AO extracts exhibited antiaging activities and enhanced longevity. We observed improved pharyngeal pumping function, attenuation of pigment accumulation (lipofuscin), and an increased lifespan of the worms. Collectively, our results demonstrated that AO extracts exerted both oxidative stress resistance and antiaging properties in the C. elegans model and may lead to new agents to benefit humans in the near future. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/31281595/Lifespan_Extending_and_Oxidative_Stress_Resistance_Properties_of_a_Leaf_Extracts_from_Anacardium_occidentale_L__in_Caenorhabditis_elegans_ L2 - https://dx.doi.org/10.1155/2019/9012396 DB - PRIME DP - Unbound Medicine ER -