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Epileptic Patient with Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy (MOGHE): A Case Report and Review of the Literature.
Case Rep Neurol Med 2019; 2019:9130780CR

Abstract

Introduction

There is an emerging interest in the literature about MOGHE (Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy). We report the case of an epileptic patient with MOGHE.

Case Report

A 33-year-old male patient was suffering from refractory focal epilepsy since adolescence. MRI demonstrated increased T2/FLAIR signal intensity of right frontal lobe. Presurgical evaluation led to definition of epileptogenic network in a specific area of right frontal lobe. The resected specimen revealed MOGHE. Discussion. MOGHE appears to be a brain entity which shares some unique histopathological features. Review of the literature is in accordance with our patient's findings. The major neuropathological finding consists of areas with blurred gray-white matter boundaries due to heterotopic neurons in white matter and increased numbers of subcortical oligodendroglial cells with increased proliferation. MR abnormalities are present in T2/FLAIR sequences. It concerns patients with refractory frontal lobe epilepsy and appears to associate with unfavourable postsurgical outcome in seizure control.

Conclusion

More cases are needed in order to establish more data about this distinct entity in frontal lobe epilepsy. This could be valuable knowledge to patients and doctors concerning expectations or management of undesirable outcome in frontal lobe epilepsy surgery.

Authors+Show Affiliations

Department of Neurosurgery, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.Department of Neuropathology, University Hospital Erlangen, Germany.Department of Neurosurgery, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.Department of Neurosurgery, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.Department of Neurosurgery, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.Department of Neurosurgery, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.Department of Neurosurgery, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.Department of Neurosurgery, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31281692

Citation

Verentzioti, A, et al. "Epileptic Patient With Mild Malformation of Cortical Development With Oligodendroglial Hyperplasia and Epilepsy (MOGHE): a Case Report and Review of the Literature." Case Reports in Neurological Medicine, vol. 2019, 2019, p. 9130780.
Verentzioti A, Blumcke I, Alexoudi A, et al. Epileptic Patient with Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy (MOGHE): A Case Report and Review of the Literature. Case Rep Neurol Med. 2019;2019:9130780.
Verentzioti, A., Blumcke, I., Alexoudi, A., Patrikelis, P., Siatouni, A., Korfias, S., ... Gatzonis, S. (2019). Epileptic Patient with Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy (MOGHE): A Case Report and Review of the Literature. Case Reports in Neurological Medicine, 2019, p. 9130780. doi:10.1155/2019/9130780.
Verentzioti A, et al. Epileptic Patient With Mild Malformation of Cortical Development With Oligodendroglial Hyperplasia and Epilepsy (MOGHE): a Case Report and Review of the Literature. Case Rep Neurol Med. 2019;2019:9130780. PubMed PMID: 31281692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epileptic Patient with Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy (MOGHE): A Case Report and Review of the Literature. AU - Verentzioti,A, AU - Blumcke,I, AU - Alexoudi,A, AU - Patrikelis,P, AU - Siatouni,A, AU - Korfias,S, AU - Sakas,D, AU - Gatzonis,S, Y1 - 2019/06/09/ PY - 2019/03/24/received PY - 2019/05/08/revised PY - 2019/05/12/accepted PY - 2019/7/9/entrez PY - 2019/7/10/pubmed PY - 2019/7/10/medline SP - 9130780 EP - 9130780 JF - Case reports in neurological medicine JO - Case Rep Neurol Med VL - 2019 N2 - Introduction: There is an emerging interest in the literature about MOGHE (Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy). We report the case of an epileptic patient with MOGHE. Case Report: A 33-year-old male patient was suffering from refractory focal epilepsy since adolescence. MRI demonstrated increased T2/FLAIR signal intensity of right frontal lobe. Presurgical evaluation led to definition of epileptogenic network in a specific area of right frontal lobe. The resected specimen revealed MOGHE. Discussion. MOGHE appears to be a brain entity which shares some unique histopathological features. Review of the literature is in accordance with our patient's findings. The major neuropathological finding consists of areas with blurred gray-white matter boundaries due to heterotopic neurons in white matter and increased numbers of subcortical oligodendroglial cells with increased proliferation. MR abnormalities are present in T2/FLAIR sequences. It concerns patients with refractory frontal lobe epilepsy and appears to associate with unfavourable postsurgical outcome in seizure control. Conclusion: More cases are needed in order to establish more data about this distinct entity in frontal lobe epilepsy. This could be valuable knowledge to patients and doctors concerning expectations or management of undesirable outcome in frontal lobe epilepsy surgery. SN - 2090-6668 UR - https://www.unboundmedicine.com/medline/citation/31281692/Epileptic_Patient_with_Mild_Malformation_of_Cortical_Development_with_Oligodendroglial_Hyperplasia_and_Epilepsy__MOGHE_:_A_Case_Report_and_Review_of_the_Literature_ L2 - https://dx.doi.org/10.1155/2019/9130780 DB - PRIME DP - Unbound Medicine ER -