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Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection.
Korean J Parasitol. 2019 Jun; 57(3):249-256.KJ

Abstract

Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform β and γ proteins significantly increased in the CSF 2-3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 β, γ, ε, and θ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges.

Authors+Show Affiliations

Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan and National Yang-Ming University, Taipei, Taiwan. Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan and National Yang-Ming University, Taipei, Taiwan.Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan and National Yang-Ming University, Taipei, Taiwan.Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan and National Yang-Ming University, Taipei, Taiwan.Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan and National Yang-Ming University, Taipei, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31284347

Citation

Tsai, Hung-Chin, et al. "Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice With Eosinophilic Meningitis Caused By Angiostrongylus Cantonensis Infection." The Korean Journal of Parasitology, vol. 57, no. 3, 2019, pp. 249-256.
Tsai HC, Chen YH, Yen CM, et al. Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection. Korean J Parasitol. 2019;57(3):249-256.
Tsai, H. C., Chen, Y. H., Yen, C. M., Chung, L. Y., Wann, S. R., Lee, S. S., & Chen, Y. S. (2019). Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection. The Korean Journal of Parasitology, 57(3), 249-256. https://doi.org/10.3347/kjp.2019.57.3.249
Tsai HC, et al. Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice With Eosinophilic Meningitis Caused By Angiostrongylus Cantonensis Infection. Korean J Parasitol. 2019;57(3):249-256. PubMed PMID: 31284347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection. AU - Tsai,Hung-Chin, AU - Chen,Yu-Hsin, AU - Yen,Chuan-Min, AU - Chung,Li-Yu, AU - Wann,Shue-Ren, AU - Lee,Susan Shin-Jung, AU - Chen,Yao-Shen, Y1 - 2019/06/30/ PY - 2019/02/03/received PY - 2019/04/09/accepted PY - 2019/7/9/entrez PY - 2019/7/10/pubmed PY - 2019/11/15/medline KW - 14-3-3 isoform KW - Angiostrongylus cantonensis KW - dexamethasone KW - eosinophile KW - meningitis SP - 249 EP - 256 JF - The Korean journal of parasitology JO - Korean J Parasitol VL - 57 IS - 3 N2 - Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform β and γ proteins significantly increased in the CSF 2-3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 β, γ, ε, and θ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges. SN - 1738-0006 UR - https://www.unboundmedicine.com/medline/citation/31284347/Dexamethasone_Downregulates_Expressions_of_14_3_3β_and_γ_Isoforms_in_Mice_with_Eosinophilic_Meningitis_Caused_by_Angiostrongylus_cantonensis_Infection_ L2 - http://www.parasitol.or.kr/kjp/DOIx.php?id=10.3347/kjp.2019.57.3.249 DB - PRIME DP - Unbound Medicine ER -