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New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015.
Mar Drugs. 2019 Jul 05; 17(7)MD

Abstract

The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1-21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR-ESI-MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL.

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Authors+Show Affiliations

Pang X
College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. College of Pharmacy, Jinan University, Guangzhou 510632, China.
Cai G
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Lin X
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Salendra L
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Zhou X
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Yang B
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Wang J
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Wang J
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. wangjunfeng@scsio.ac.cn.
Xu S
College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China. txush@jnu.edu.cn.
Liu Y
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. yonghongliu@scsio.ac.cn.

MeSH

A549 CellsAlkaloidsAnimalsAnti-Bacterial AgentsAquatic OrganismsBacteriaCell Line, TumorFungiHumansMicrobial Sensitivity TestsPenicilliumPolyketidesPoriferaPyrones

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31284448

Citation

Pang, Xiaoyan, et al. "New Alkaloids and Polyketides From the Marine Sponge-Derived Fungus Penicillium Sp. SCSIO41015." Marine Drugs, vol. 17, no. 7, 2019.
Pang X, Cai G, Lin X, et al. New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015. Mar Drugs. 2019;17(7).
Pang, X., Cai, G., Lin, X., Salendra, L., Zhou, X., Yang, B., Wang, J., Wang, J., Xu, S., & Liu, Y. (2019). New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015. Marine Drugs, 17(7). https://doi.org/10.3390/md17070398
Pang X, et al. New Alkaloids and Polyketides From the Marine Sponge-Derived Fungus Penicillium Sp. SCSIO41015. Mar Drugs. 2019 Jul 5;17(7) PubMed PMID: 31284448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015. AU - Pang,Xiaoyan, AU - Cai,Guodi, AU - Lin,Xiuping, AU - Salendra,Limbadri, AU - Zhou,Xuefeng, AU - Yang,Bin, AU - Wang,Junjian, AU - Wang,Junfeng, AU - Xu,Shihai, AU - Liu,Yonghong, Y1 - 2019/07/05/ PY - 2019/05/26/received PY - 2019/06/24/revised PY - 2019/06/26/accepted PY - 2019/7/10/entrez PY - 2019/7/10/pubmed PY - 2019/12/20/medline KW - Penicillium sp. KW - X-ray single crystal diffraction KW - alkaloid KW - antibacterial KW - cytotoxic activity KW - sponge-derived fungus JF - Marine drugs JO - Mar Drugs VL - 17 IS - 7 N2 - The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1-21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR-ESI-MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL. SN - 1660-3397 UR - https://www.unboundmedicine.com/medline/citation/31284448/New_Alkaloids_and_Polyketides_from_the_Marine_Sponge_Derived_Fungus_Penicillium_sp__SCSIO41015_ DB - PRIME DP - Unbound Medicine ER -