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Mechanism of the Formation of Electronically Excited Species by Oxidative Metabolic Processes: Role of Reactive Oxygen Species.
Biomolecules 2019; 9(7)B

Abstract

It is well known that biological systems, such as microorganisms, plants, and animals, including human beings, form spontaneous electronically excited species through oxidative metabolic processes. Though the mechanism responsible for the formation of electronically excited species is still not clearly understood, several lines of evidence suggest that reactive oxygen species (ROS) are involved in the formation of electronically excited species. This review attempts to describe the role of ROS in the formation of electronically excited species during oxidative metabolic processes. Briefly, the oxidation of biomolecules, such as lipids, proteins, and nucleic acids by ROS initiates a cascade of reactions that leads to the formation of triplet excited carbonyls formed by the decomposition of cyclic (1,2-dioxetane) and linear (tetroxide) high-energy intermediates. When chromophores are in proximity to triplet excited carbonyls, the triplet-singlet and triplet-triplet energy transfers from triplet excited carbonyls to chromophores result in the formation of singlet and triplet excited chromophores, respectively. Alternatively, when molecular oxygen is present, the triplet-singlet energy transfer from triplet excited carbonyls to molecular oxygen initiates the formation of singlet oxygen. Understanding the mechanism of the formation of electronically excited species allows us to use electronically excited species as a marker for oxidative metabolic processes in cells.

Authors+Show Affiliations

Department of Biophysics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic. pavel.pospisil@upol.cz.Department of Biophysics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.Department of Biophysics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31284470

Citation

Pospíšil, Pavel, et al. "Mechanism of the Formation of Electronically Excited Species By Oxidative Metabolic Processes: Role of Reactive Oxygen Species." Biomolecules, vol. 9, no. 7, 2019.
Pospíšil P, Prasad A, Rác M. Mechanism of the Formation of Electronically Excited Species by Oxidative Metabolic Processes: Role of Reactive Oxygen Species. Biomolecules. 2019;9(7).
Pospíšil, P., Prasad, A., & Rác, M. (2019). Mechanism of the Formation of Electronically Excited Species by Oxidative Metabolic Processes: Role of Reactive Oxygen Species. Biomolecules, 9(7), doi:10.3390/biom9070258.
Pospíšil P, Prasad A, Rác M. Mechanism of the Formation of Electronically Excited Species By Oxidative Metabolic Processes: Role of Reactive Oxygen Species. Biomolecules. 2019 07 5;9(7) PubMed PMID: 31284470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanism of the Formation of Electronically Excited Species by Oxidative Metabolic Processes: Role of Reactive Oxygen Species. AU - Pospíšil,Pavel, AU - Prasad,Ankush, AU - Rác,Marek, Y1 - 2019/07/05/ PY - 2019/06/04/received PY - 2019/06/28/revised PY - 2019/06/30/accepted PY - 2019/7/10/entrez PY - 2019/7/10/pubmed PY - 2019/7/10/medline KW - chromophores KW - electronically excited species KW - hydrogen peroxide KW - hydroxyl radical KW - oxidative radical reactions KW - reactive oxygen species KW - singlet oxygen KW - superoxide anion radical JF - Biomolecules JO - Biomolecules VL - 9 IS - 7 N2 - It is well known that biological systems, such as microorganisms, plants, and animals, including human beings, form spontaneous electronically excited species through oxidative metabolic processes. Though the mechanism responsible for the formation of electronically excited species is still not clearly understood, several lines of evidence suggest that reactive oxygen species (ROS) are involved in the formation of electronically excited species. This review attempts to describe the role of ROS in the formation of electronically excited species during oxidative metabolic processes. Briefly, the oxidation of biomolecules, such as lipids, proteins, and nucleic acids by ROS initiates a cascade of reactions that leads to the formation of triplet excited carbonyls formed by the decomposition of cyclic (1,2-dioxetane) and linear (tetroxide) high-energy intermediates. When chromophores are in proximity to triplet excited carbonyls, the triplet-singlet and triplet-triplet energy transfers from triplet excited carbonyls to chromophores result in the formation of singlet and triplet excited chromophores, respectively. Alternatively, when molecular oxygen is present, the triplet-singlet energy transfer from triplet excited carbonyls to molecular oxygen initiates the formation of singlet oxygen. Understanding the mechanism of the formation of electronically excited species allows us to use electronically excited species as a marker for oxidative metabolic processes in cells. SN - 2218-273X UR - https://www.unboundmedicine.com/medline/citation/31284470/Mechanism_of_the_Formation_of_Electronically_Excited_Species_by_Oxidative_Metabolic_Processes:_Role_of_Reactive_Oxygen_Species_ L2 - http://www.mdpi.com/resolver?pii=biom9070258 DB - PRIME DP - Unbound Medicine ER -