Tags

Type your tag names separated by a space and hit enter

Structure-Antioxidant-Antiproliferative Activity Relationships of Natural C7 and C7-C8 Hydroxylated Flavones and Flavanones.
Antioxidants (Basel). 2019 Jul 07; 8(7)A

Abstract

Common food flavonoids: chrysin, apigenin, luteolin, diosmetin, pinocembrin, naringenin, eriodictyol, hesperetin, and their analogues with an additional hydroxyl group at the C-8 position obtained via biotransformation were tested for antioxidant activity using the ABTS, DPPH, and ferric ion reducing antioxidant power (FRAP) methods. They were also tested for antiproliferative activity against selected human cancer cell lines-MV-4-11 (biphenotypic B myelomonocytic leukemia), MCF7 (breast carcinoma), LoVo (colon cancer), LoVo/DX (colon cancer doxorubicin resistant), and DU 145 (prostate cancer)-and two normal human cell lines-MCF 10A (breast cells) and HLMEC (lung microvascular endothelial cells). Flavonoids with a C7-C8 catechol moiety indicated much higher antioxidant activity compared with the C7 hydroxy analogues. However, because they were unstable under the assay conditions, they did not show antiproliferative activity or it was very low.

Authors+Show Affiliations

Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland. sandra.sordon@upwr.edu.pl.Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wrocław, Poland.Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wrocław, Poland.Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.Department of Fruit, Vegetable and Plant Nutraceutical Technology, Wrocław University of Environmental and Life Sciences, Chełmońskiego 37, 51-630 Wrocław, Poland.Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wrocław, Poland.Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31284642

Citation

Sordon, Sandra, et al. "Structure-Antioxidant-Antiproliferative Activity Relationships of Natural C7 and C7-C8 Hydroxylated Flavones and Flavanones." Antioxidants (Basel, Switzerland), vol. 8, no. 7, 2019.
Sordon S, Popłoński J, Milczarek M, et al. Structure-Antioxidant-Antiproliferative Activity Relationships of Natural C7 and C7-C8 Hydroxylated Flavones and Flavanones. Antioxidants (Basel). 2019;8(7).
Sordon, S., Popłoński, J., Milczarek, M., Stachowicz, M., Tronina, T., Kucharska, A. Z., Wietrzyk, J., & Huszcza, E. (2019). Structure-Antioxidant-Antiproliferative Activity Relationships of Natural C7 and C7-C8 Hydroxylated Flavones and Flavanones. Antioxidants (Basel, Switzerland), 8(7). https://doi.org/10.3390/antiox8070210
Sordon S, et al. Structure-Antioxidant-Antiproliferative Activity Relationships of Natural C7 and C7-C8 Hydroxylated Flavones and Flavanones. Antioxidants (Basel). 2019 Jul 7;8(7) PubMed PMID: 31284642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structure-Antioxidant-Antiproliferative Activity Relationships of Natural C7 and C7-C8 Hydroxylated Flavones and Flavanones. AU - Sordon,Sandra, AU - Popłoński,Jarosław, AU - Milczarek,Magdalena, AU - Stachowicz,Martyna, AU - Tronina,Tomasz, AU - Kucharska,Alicja Z, AU - Wietrzyk,Joanna, AU - Huszcza,Ewa, Y1 - 2019/07/07/ PY - 2019/05/21/received PY - 2019/07/04/revised PY - 2019/07/05/accepted PY - 2019/7/10/entrez PY - 2019/7/10/pubmed PY - 2019/7/10/medline KW - anticancer activity KW - antioxidant activity KW - catechol moiety KW - flavanones KW - flavones KW - hydroxylation JF - Antioxidants (Basel, Switzerland) JO - Antioxidants (Basel) VL - 8 IS - 7 N2 - Common food flavonoids: chrysin, apigenin, luteolin, diosmetin, pinocembrin, naringenin, eriodictyol, hesperetin, and their analogues with an additional hydroxyl group at the C-8 position obtained via biotransformation were tested for antioxidant activity using the ABTS, DPPH, and ferric ion reducing antioxidant power (FRAP) methods. They were also tested for antiproliferative activity against selected human cancer cell lines-MV-4-11 (biphenotypic B myelomonocytic leukemia), MCF7 (breast carcinoma), LoVo (colon cancer), LoVo/DX (colon cancer doxorubicin resistant), and DU 145 (prostate cancer)-and two normal human cell lines-MCF 10A (breast cells) and HLMEC (lung microvascular endothelial cells). Flavonoids with a C7-C8 catechol moiety indicated much higher antioxidant activity compared with the C7 hydroxy analogues. However, because they were unstable under the assay conditions, they did not show antiproliferative activity or it was very low. SN - 2076-3921 UR - https://www.unboundmedicine.com/medline/citation/31284642/Structure_Antioxidant_Antiproliferative_Activity_Relationships_of_Natural_C7_and_C7_C8_Hydroxylated_Flavones_and_Flavanones_ L2 - http://www.mdpi.com/resolver?pii=antiox8070210 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.