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The Effects of Transdermal Nicotine Patches on the Cardiorespiratory and Lactate Responses During Exercise from Light to Moderate Intensity: Implications for Exercise Prescription during Smoking Cessation.
Medicina (Kaunas) 2019; 55(7)M

Abstract

Background and objectives: Exercise can help ease withdrawal symptoms of smokers. However, there is little information about the physiological responses, such as cardiorespiratory and lactate (La) responses, during exercise from light to moderate intensity combined with transdermal nicotine patches (TNPs) in smokers. This study aimed to investigate the effect of TNPs on the cardiorespiratory and La responses during exercise at light to moderate intensity. Materials and

Methods:

Fourteen young men (8 non-smokers, 6 current smokers) aged 20 to 26 years participated in this study. They performed an incremental graded submaximal exercise test using an electromagnetic cycle ergometer set from 30 to 210 W with (TNP condition) or without a TNP (control condition) in a random order. The TNP was applied to the left arm 8-10 h prior to starting the exercise to achieve the peak level of blood nicotine concentration. Heart rate (HR), rate of perceived exertion (RPE), oxygen consumption (VO2), ventilation (VE), and blood La at rest and during exercise were measured and analyzed.

Results:

The HR at rest was significantly higher in the TNP condition than in the control condition (TNP; 74.7 ± 13.8 bpm, control; 65.3 ± 10.8 bpm, p < 0.001). There was no interaction (condition × exercise intensity) between any of the variables, and VO2, VE, RPE, and La during exercise were not significantly different between the conditions. However, HR during exercise was 6.7 bpm higher on average in the TNP condition.

Conclusions:

The HR during exercise was greater at light to moderate intensity with a TNP. Our study results will guide clinicians or health professionals when prescribing exercise programs combined with TNPs for healthy young smokers.

Authors+Show Affiliations

Graduate School of Health and Sports Science, Juntendo University, Hiraka-gakuendai 1-1, Inzai, Chiba 270-1695, Japan. tanakaga@juntendo.ac.jp. National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan. tanakaga@juntendo.ac.jp.Graduate School of Health and Sports Science, Juntendo University, Hiraka-gakuendai 1-1, Inzai, Chiba 270-1695, Japan.Graduate School of Health and Sports Science, Juntendo University, Hiraka-gakuendai 1-1, Inzai, Chiba 270-1695, Japan. Mito Medical Center, Tsukuba University Hospital, 1-1-1 Tennodai, Tsukuba, Ibaraki 310-0015, Japan.Graduate School of Health and Sports Science, Juntendo University, Hiraka-gakuendai 1-1, Inzai, Chiba 270-1695, Japan.Graduate School of Health and Sports Science, Juntendo University, Hiraka-gakuendai 1-1, Inzai, Chiba 270-1695, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31284668

Citation

Nakagata, Takashi, et al. "The Effects of Transdermal Nicotine Patches On the Cardiorespiratory and Lactate Responses During Exercise From Light to Moderate Intensity: Implications for Exercise Prescription During Smoking Cessation." Medicina (Kaunas, Lithuania), vol. 55, no. 7, 2019.
Nakagata T, Fukao K, Kobayashi H, et al. The Effects of Transdermal Nicotine Patches on the Cardiorespiratory and Lactate Responses During Exercise from Light to Moderate Intensity: Implications for Exercise Prescription during Smoking Cessation. Medicina (Kaunas). 2019;55(7).
Nakagata, T., Fukao, K., Kobayashi, H., Katamoto, S., & Naito, H. (2019). The Effects of Transdermal Nicotine Patches on the Cardiorespiratory and Lactate Responses During Exercise from Light to Moderate Intensity: Implications for Exercise Prescription during Smoking Cessation. Medicina (Kaunas, Lithuania), 55(7), doi:10.3390/medicina55070348.
Nakagata T, et al. The Effects of Transdermal Nicotine Patches On the Cardiorespiratory and Lactate Responses During Exercise From Light to Moderate Intensity: Implications for Exercise Prescription During Smoking Cessation. Medicina (Kaunas). 2019 Jul 7;55(7) PubMed PMID: 31284668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effects of Transdermal Nicotine Patches on the Cardiorespiratory and Lactate Responses During Exercise from Light to Moderate Intensity: Implications for Exercise Prescription during Smoking Cessation. AU - Nakagata,Takashi, AU - Fukao,Kosuke, AU - Kobayashi,Hiroyuki, AU - Katamoto,Shizuo, AU - Naito,Hisashi, Y1 - 2019/07/07/ PY - 2019/05/07/received PY - 2019/07/04/revised PY - 2019/07/04/accepted PY - 2019/7/10/entrez PY - 2019/7/10/pubmed PY - 2019/7/10/medline KW - cardiovascular disease KW - clinical setting KW - exercise prescription KW - exercise program KW - heart rate KW - mortality KW - smoking cessation KW - smoking habits KW - weight gain JF - Medicina (Kaunas, Lithuania) JO - Medicina (Kaunas) VL - 55 IS - 7 N2 - Background and objectives: Exercise can help ease withdrawal symptoms of smokers. However, there is little information about the physiological responses, such as cardiorespiratory and lactate (La) responses, during exercise from light to moderate intensity combined with transdermal nicotine patches (TNPs) in smokers. This study aimed to investigate the effect of TNPs on the cardiorespiratory and La responses during exercise at light to moderate intensity. Materials and Methods: Fourteen young men (8 non-smokers, 6 current smokers) aged 20 to 26 years participated in this study. They performed an incremental graded submaximal exercise test using an electromagnetic cycle ergometer set from 30 to 210 W with (TNP condition) or without a TNP (control condition) in a random order. The TNP was applied to the left arm 8-10 h prior to starting the exercise to achieve the peak level of blood nicotine concentration. Heart rate (HR), rate of perceived exertion (RPE), oxygen consumption (VO2), ventilation (VE), and blood La at rest and during exercise were measured and analyzed. Results: The HR at rest was significantly higher in the TNP condition than in the control condition (TNP; 74.7 ± 13.8 bpm, control; 65.3 ± 10.8 bpm, p < 0.001). There was no interaction (condition × exercise intensity) between any of the variables, and VO2, VE, RPE, and La during exercise were not significantly different between the conditions. However, HR during exercise was 6.7 bpm higher on average in the TNP condition. Conclusions: The HR during exercise was greater at light to moderate intensity with a TNP. Our study results will guide clinicians or health professionals when prescribing exercise programs combined with TNPs for healthy young smokers. SN - 1648-9144 UR - https://www.unboundmedicine.com/medline/citation/31284668/The_Effects_of_Transdermal_Nicotine_Patches_on_the_Cardiorespiratory_and_Lactate_Responses_During_Exercise_from_Light_to_Moderate_Intensity:_Implications_for_Exercise_Prescription_during_Smoking_Cessation L2 - http://www.mdpi.com/resolver?pii=medicina55070348 DB - PRIME DP - Unbound Medicine ER -