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Successful treatment of ciguatera fish poisoning with intravenous mannitol.
JAMA. 1988 May 13; 259(18):2740-2.JAMA

Abstract

Twenty-four patients with acute ciguatera fish poisoning were treated with intravenous mannitol, and each patient's condition improved dramatically. All exhibited marked lessening of neurologic and muscular dysfunction within minutes of the administration of mannitol. Gastrointestinal symptoms disappeared more slowly. Two patients in coma and one in shock responded within minutes, with full recovery after infusion. Although these observations were empiric and uncontrolled and the mechanism of action of mannitol in this disease is unclear, mannitol should be considered for initial use in patients with significant illness and morbidity from ciguatera fish poisoning.

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Authors+Show Affiliations

Palafox NA
Armer Ishoda Memorial Hospital, Majuro, Marshall Islands.
Jain LG
No affiliation info available
Pinano AZ
No affiliation info available
Gulick TM
No affiliation info available
Williams RK
No affiliation info available
Schatz IJ
No affiliation info available

MeSH

AdolescentAdultAgedAnimalsChildCiguatera PoisoningFemaleFishesHumansInfusions, IntravenousMaleMannitolMarine ToxinsMicronesiaRecurrence

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

3128666

Citation

Palafox, N A., et al. "Successful Treatment of Ciguatera Fish Poisoning With Intravenous Mannitol." JAMA, vol. 259, no. 18, 1988, pp. 2740-2.
Palafox NA, Jain LG, Pinano AZ, et al. Successful treatment of ciguatera fish poisoning with intravenous mannitol. JAMA. 1988;259(18):2740-2.
Palafox, N. A., Jain, L. G., Pinano, A. Z., Gulick, T. M., Williams, R. K., & Schatz, I. J. (1988). Successful treatment of ciguatera fish poisoning with intravenous mannitol. JAMA, 259(18), 2740-2.
Palafox NA, et al. Successful Treatment of Ciguatera Fish Poisoning With Intravenous Mannitol. JAMA. 1988 May 13;259(18):2740-2. PubMed PMID: 3128666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment of ciguatera fish poisoning with intravenous mannitol. AU - Palafox,N A, AU - Jain,L G, AU - Pinano,A Z, AU - Gulick,T M, AU - Williams,R K, AU - Schatz,I J, PY - 1988/5/13/pubmed PY - 1988/5/13/medline PY - 1988/5/13/entrez SP - 2740 EP - 2 JF - JAMA JO - JAMA VL - 259 IS - 18 N2 - Twenty-four patients with acute ciguatera fish poisoning were treated with intravenous mannitol, and each patient's condition improved dramatically. All exhibited marked lessening of neurologic and muscular dysfunction within minutes of the administration of mannitol. Gastrointestinal symptoms disappeared more slowly. Two patients in coma and one in shock responded within minutes, with full recovery after infusion. Although these observations were empiric and uncontrolled and the mechanism of action of mannitol in this disease is unclear, mannitol should be considered for initial use in patients with significant illness and morbidity from ciguatera fish poisoning. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/3128666/Successful_treatment_of_ciguatera_fish_poisoning_with_intravenous_mannitol_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/259/pg/2740 DB - PRIME DP - Unbound Medicine ER -