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Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older.
Am J Clin Nutr. 2019 09 01; 110(3):691-700.AJ

Abstract

BACKGROUND

Although a number of studies have examined the association between alcohol intake and hip fractures, few have considered specific alcoholic beverages separately.

OBJECTIVES

We prospectively assessed total alcohol and specific alcoholic beverage consumption and risk of hip fractures in US men and women.

METHODS

Health, lifestyle information, and hip fractures were self-reported on biennial questionnaires between 1980 and 2014 in 75,180 postmenopausal women from the Nurses' Health Study, and between 1986 and 2014 in 38,398 men aged ≥50 y from the Health Professionals Follow-Up Study. Diet was assessed approximately every 4 y with a semiquantitative FFQ. RRs were computed for hip fracture using Cox proportional hazards models, adjusting for potential confounders.

RESULTS

We ascertained 2360 incident low trauma hip fractures in women and 709 in men. Among women, RRs for low trauma hip fractures compared with nondrinkers were 0.89 (95% CI: 0.80, 0.99) for an average daily consumption of <5.0 g, 0.81 (95% CI: 0.70, 0.94) for 5.0 to <10.0 g, 0.83 (95% CI: 0.71, 0.96) for 10.0 to <20.0 g, and 0.93 (95% CI: 0.78, 1.10) for ≥20.0 g. Among men, risk declined linearly with higher alcohol consumption (P-trend = 0.002). Multivariable RR compared with nondrinkers was 0.77 (95% CI: 0.59, 1.01), 0.69 (0.49, 0.96), and 0.67 (0.48, 0.95) for an average intake of 10 g/d to <20 g/d, 20 g/d to <30 g/d, and 30.0 g/d or more, respectively. In women, the alcoholic beverage most significantly associated with hip fracture risk was red wine (RR per serving = 0.59; 95% CI: 0.45, 0.79). In men, there was no clear association with specific alcoholic beverages.

CONCLUSION

In these 2 US cohorts, low to moderate alcohol consumption, when compared with no consumption, was associated with a lower risk of hip fractures, particularly with red wine consumption among women.

Authors+Show Affiliations

Department of Nutrition, Simmons University, Boston, MA, USA. Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.Department of Community Medicine and Global Health, University of Oslo, Oslo, Norway.Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31287144

Citation

Fung, Teresa T., et al. "Alcohol Intake, Specific Alcoholic Beverages, and Risk of Hip Fractures in Postmenopausal Women and Men Age 50 and Older." The American Journal of Clinical Nutrition, vol. 110, no. 3, 2019, pp. 691-700.
Fung TT, Mukamal KJ, Rimm EB, et al. Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older. Am J Clin Nutr. 2019;110(3):691-700.
Fung, T. T., Mukamal, K. J., Rimm, E. B., Meyer, H. E., Willett, W. C., & Feskanich, D. (2019). Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older. The American Journal of Clinical Nutrition, 110(3), 691-700. https://doi.org/10.1093/ajcn/nqz135
Fung TT, et al. Alcohol Intake, Specific Alcoholic Beverages, and Risk of Hip Fractures in Postmenopausal Women and Men Age 50 and Older. Am J Clin Nutr. 2019 09 1;110(3):691-700. PubMed PMID: 31287144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older. AU - Fung,Teresa T, AU - Mukamal,Kenneth J, AU - Rimm,Eric B, AU - Meyer,Haakon E, AU - Willett,Walter C, AU - Feskanich,Diane, PY - 2018/09/21/received PY - 2019/06/06/accepted PY - 2019/7/10/pubmed PY - 2020/3/25/medline PY - 2019/7/10/entrez KW - alcohol KW - beer KW - epidemiology KW - fractures KW - liquor KW - nutrition KW - wine SP - 691 EP - 700 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 110 IS - 3 N2 - BACKGROUND: Although a number of studies have examined the association between alcohol intake and hip fractures, few have considered specific alcoholic beverages separately. OBJECTIVES: We prospectively assessed total alcohol and specific alcoholic beverage consumption and risk of hip fractures in US men and women. METHODS: Health, lifestyle information, and hip fractures were self-reported on biennial questionnaires between 1980 and 2014 in 75,180 postmenopausal women from the Nurses' Health Study, and between 1986 and 2014 in 38,398 men aged ≥50 y from the Health Professionals Follow-Up Study. Diet was assessed approximately every 4 y with a semiquantitative FFQ. RRs were computed for hip fracture using Cox proportional hazards models, adjusting for potential confounders. RESULTS: We ascertained 2360 incident low trauma hip fractures in women and 709 in men. Among women, RRs for low trauma hip fractures compared with nondrinkers were 0.89 (95% CI: 0.80, 0.99) for an average daily consumption of <5.0 g, 0.81 (95% CI: 0.70, 0.94) for 5.0 to <10.0 g, 0.83 (95% CI: 0.71, 0.96) for 10.0 to <20.0 g, and 0.93 (95% CI: 0.78, 1.10) for ≥20.0 g. Among men, risk declined linearly with higher alcohol consumption (P-trend = 0.002). Multivariable RR compared with nondrinkers was 0.77 (95% CI: 0.59, 1.01), 0.69 (0.49, 0.96), and 0.67 (0.48, 0.95) for an average intake of 10 g/d to <20 g/d, 20 g/d to <30 g/d, and 30.0 g/d or more, respectively. In women, the alcoholic beverage most significantly associated with hip fracture risk was red wine (RR per serving = 0.59; 95% CI: 0.45, 0.79). In men, there was no clear association with specific alcoholic beverages. CONCLUSION: In these 2 US cohorts, low to moderate alcohol consumption, when compared with no consumption, was associated with a lower risk of hip fractures, particularly with red wine consumption among women. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/31287144/Alcohol_intake_specific_alcoholic_beverages_and_risk_of_hip_fractures_in_postmenopausal_women_and_men_age_50_and_older_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/nqz135 DB - PRIME DP - Unbound Medicine ER -