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Caffeine, Type of Coffee, and Risk of Ovarian Cancer: A Dose-Response Meta-Analysis of Prospective Studies.
J Clin Endocrinol Metab. 2019 11 01; 104(11):5349-5359.JC

Abstract

CONTEXT

Prospective studies on caffeine and different types of coffee intake in relation to the risk of ovarian cancer have shown conflicting results.

OBJECTIVE

The aim of the present study was to perform a dose-response meta-analysis of cohort studies on the association between dietary caffeine intake, different types of coffee consumption, and the risk of ovarian cancer.

DATA SOURCES

PubMed/Medline, ISI Web of Science, Scopus, and EMBASE were searched to identify relevant studies reported until October 2018.

STUDY SELECTION

Prospective cohort studies that had considered caffeine or different types of coffee as the exposure variable and ovarian cancer as the main outcome variable or as one of the outcome variables were included in our systematic review and meta-analysis. Two of us independently screened 9344 publications. A total of 14 cohort studies were included in the meta-analysis.

DATA EXTRACTION

Two of us independently extracted the data. Any disagreements were resolved in consultation with the principal investigator.

RESULTS

Combining 13 effect sizes, we found no substantial association between coffee consumption and risk of ovarian cancer [risk ratio (RR), 1.08; 95% CI, 0.89 to 1.33]. Also, one additional cup daily of coffee consumption was marginally associated with an increased risk of ovarian cancer (RR, 1.02; 95% CI, 0.99 to 1.05; P = 0.21; I2 = 0.0%; Pheterogeneity = 0.68). No statistically significant association was observed between caffeine intake or caffeinated or decaffeinated coffee consumption and the risk of ovarian cancer.

CONCLUSIONS

We found no statistically significant association between caffeine intake or different types of coffee and the risk of ovarian cancer.

Authors+Show Affiliations

Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

31287542

Citation

Salari-Moghaddam, Asma, et al. "Caffeine, Type of Coffee, and Risk of Ovarian Cancer: a Dose-Response Meta-Analysis of Prospective Studies." The Journal of Clinical Endocrinology and Metabolism, vol. 104, no. 11, 2019, pp. 5349-5359.
Salari-Moghaddam A, Milajerdi A, Surkan PJ, et al. Caffeine, Type of Coffee, and Risk of Ovarian Cancer: A Dose-Response Meta-Analysis of Prospective Studies. J Clin Endocrinol Metab. 2019;104(11):5349-5359.
Salari-Moghaddam, A., Milajerdi, A., Surkan, P. J., Larijani, B., & Esmaillzadeh, A. (2019). Caffeine, Type of Coffee, and Risk of Ovarian Cancer: A Dose-Response Meta-Analysis of Prospective Studies. The Journal of Clinical Endocrinology and Metabolism, 104(11), 5349-5359. https://doi.org/10.1210/jc.2019-00637
Salari-Moghaddam A, et al. Caffeine, Type of Coffee, and Risk of Ovarian Cancer: a Dose-Response Meta-Analysis of Prospective Studies. J Clin Endocrinol Metab. 2019 11 1;104(11):5349-5359. PubMed PMID: 31287542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine, Type of Coffee, and Risk of Ovarian Cancer: A Dose-Response Meta-Analysis of Prospective Studies. AU - Salari-Moghaddam,Asma, AU - Milajerdi,Alireza, AU - Surkan,Pamela J, AU - Larijani,Bagher, AU - Esmaillzadeh,Ahmad, PY - 2019/03/16/received PY - 2019/07/02/accepted PY - 2019/7/10/pubmed PY - 2020/6/2/medline PY - 2019/7/10/entrez SP - 5349 EP - 5359 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 104 IS - 11 N2 - CONTEXT: Prospective studies on caffeine and different types of coffee intake in relation to the risk of ovarian cancer have shown conflicting results. OBJECTIVE: The aim of the present study was to perform a dose-response meta-analysis of cohort studies on the association between dietary caffeine intake, different types of coffee consumption, and the risk of ovarian cancer. DATA SOURCES: PubMed/Medline, ISI Web of Science, Scopus, and EMBASE were searched to identify relevant studies reported until October 2018. STUDY SELECTION: Prospective cohort studies that had considered caffeine or different types of coffee as the exposure variable and ovarian cancer as the main outcome variable or as one of the outcome variables were included in our systematic review and meta-analysis. Two of us independently screened 9344 publications. A total of 14 cohort studies were included in the meta-analysis. DATA EXTRACTION: Two of us independently extracted the data. Any disagreements were resolved in consultation with the principal investigator. RESULTS: Combining 13 effect sizes, we found no substantial association between coffee consumption and risk of ovarian cancer [risk ratio (RR), 1.08; 95% CI, 0.89 to 1.33]. Also, one additional cup daily of coffee consumption was marginally associated with an increased risk of ovarian cancer (RR, 1.02; 95% CI, 0.99 to 1.05; P = 0.21; I2 = 0.0%; Pheterogeneity = 0.68). No statistically significant association was observed between caffeine intake or caffeinated or decaffeinated coffee consumption and the risk of ovarian cancer. CONCLUSIONS: We found no statistically significant association between caffeine intake or different types of coffee and the risk of ovarian cancer. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/31287542/Caffeine_Type_of_Coffee_and_Risk_of_Ovarian_Cancer:_A_Dose_Response_Meta_Analysis_of_Prospective_Studies_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2019-00637 DB - PRIME DP - Unbound Medicine ER -