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Concise Review: Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration.
Stem Cells 2019SC

Abstract

Since the discovery of stem cells and multipotency characteristics of mesenchymal stem cells (MSCs), there has been tremendous development in regenerative medicine. MSCs derived from bone marrow have been widely used in various research applications, yet there are limitations such as invasiveness of obtaining samples, low yield and proliferation rate, and questions regarding their practicality in clinical applications. Some have suggested that MSCs from other sources, specifically those derived from palatine tonsil tissues, that is, tonsil-derived MSCs (TMSCs), could be considered as a new potential therapeutic tool in regenerative medicine due to their superior proliferation rate and differentiation capabilities with low immunogenicity and ease of obtaining. Several studies have determined that TMSCs have differentiation potentials not only into the mesodermal lineage but also into the endodermal as well as ectodermal lineages, expanding their potential usage and placing them as an appealing option to consider for future studies in regenerative medicine. In this review, the differentiation capacities of TMSCs and their therapeutic competencies from past studies are addressed. Stem Cells 2019.

Authors+Show Affiliations

Department of Molecular Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.Department of Molecular Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.Department of Molecular Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju, Republic of Korea.Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.Department of Microbiology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.Department of Molecular Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31287931

Citation

Oh, Se-Young, et al. "Concise Review: Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration." Stem Cells (Dayton, Ohio), 2019.
Oh SY, Choi YM, Kim HY, et al. Concise Review: Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration. Stem Cells. 2019.
Oh, S. Y., Choi, Y. M., Kim, H. Y., Park, Y. S., Jung, S. C., Park, J. W., ... Jo, I. (2019). Concise Review: Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration. Stem Cells (Dayton, Ohio), doi:10.1002/stem.3058.
Oh SY, et al. Concise Review: Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration. Stem Cells. 2019 Jul 9; PubMed PMID: 31287931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concise Review: Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration. AU - Oh,Se-Young, AU - Choi,Young Min, AU - Kim,Ha Yeong, AU - Park,Yoon Shin, AU - Jung,Sung-Chul, AU - Park,Joo-Won, AU - Woo,So-Youn, AU - Ryu,Kyung-Ha, AU - Kim,Han Su, AU - Jo,Inho, Y1 - 2019/07/09/ PY - 2019/04/17/received PY - 2019/05/23/revised PY - 2019/06/25/accepted PY - 2019/7/10/pubmed PY - 2019/7/10/medline PY - 2019/7/10/entrez KW - Differentiation KW - Immunomodulation KW - Mesenchymal stem cells KW - Regenerative medicine KW - Tissue engineering JF - Stem cells (Dayton, Ohio) JO - Stem Cells N2 - Since the discovery of stem cells and multipotency characteristics of mesenchymal stem cells (MSCs), there has been tremendous development in regenerative medicine. MSCs derived from bone marrow have been widely used in various research applications, yet there are limitations such as invasiveness of obtaining samples, low yield and proliferation rate, and questions regarding their practicality in clinical applications. Some have suggested that MSCs from other sources, specifically those derived from palatine tonsil tissues, that is, tonsil-derived MSCs (TMSCs), could be considered as a new potential therapeutic tool in regenerative medicine due to their superior proliferation rate and differentiation capabilities with low immunogenicity and ease of obtaining. Several studies have determined that TMSCs have differentiation potentials not only into the mesodermal lineage but also into the endodermal as well as ectodermal lineages, expanding their potential usage and placing them as an appealing option to consider for future studies in regenerative medicine. In this review, the differentiation capacities of TMSCs and their therapeutic competencies from past studies are addressed. Stem Cells 2019. SN - 1549-4918 UR - https://www.unboundmedicine.com/medline/citation/31287931/Concise_Review:_Application_of_tonsil-derived_mesenchymal_stem_cells_in_tissue_regeneration L2 - https://doi.org/10.1002/stem.3058 DB - PRIME DP - Unbound Medicine ER -