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Asenapine: Pharmacological Aspects and Role in Psychiatric Disorders.
Psychiatr Danub. 2019 Jun; 31(2):157-161.PD

Abstract

Schizophrenia and bipolar disorders are serious psychiatric disorders with substantial health risks. Asenapine is a new second-generation antipsychotic, available as a sublingual tablet, approved in Europe for the treatment of moderate-to-severe manic episodes in adults, and in US for manic or mixed episodes of bipolar I disorder in adults and adolescents. In this review, we searched the available literature to appreciate the role of asenapine in the management of psychiatric conditions such as bipolar disorders and schizophrenia and describe its mechanism of action, efficacy and tolerability. Asenapine has demonstrated efficacy in the management of bipolar disorders and schizophrenia, while a possible role in the management of borderline personality disorder and agitation needs further research. Asenapine has favourable side effects profile and combining with other pharmacological treatment in post-traumatic stress disorder has shown promising results. Asenapine fulfils important requirements of efficacy and tolerability as an anti-psychotic. These findings should support psychiatrists and pharmacists in the care of their patients while on asenapine.

Authors+Show Affiliations

School of Pharmacy, University of Wolverhampton, WV1 1LY, Wolverhampton, UK, a.antounreyad@wlv.ac.uk.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31291219

Citation

Reyad, Ayman Antoun, and Raafat Mishriky. "Asenapine: Pharmacological Aspects and Role in Psychiatric Disorders." Psychiatria Danubina, vol. 31, no. 2, 2019, pp. 157-161.
Reyad AA, Mishriky R. Asenapine: Pharmacological Aspects and Role in Psychiatric Disorders. Psychiatr Danub. 2019;31(2):157-161.
Reyad, A. A., & Mishriky, R. (2019). Asenapine: Pharmacological Aspects and Role in Psychiatric Disorders. Psychiatria Danubina, 31(2), 157-161. https://doi.org/10.24869/psyd.2019.157
Reyad AA, Mishriky R. Asenapine: Pharmacological Aspects and Role in Psychiatric Disorders. Psychiatr Danub. 2019;31(2):157-161. PubMed PMID: 31291219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asenapine: Pharmacological Aspects and Role in Psychiatric Disorders. AU - Reyad,Ayman Antoun, AU - Mishriky,Raafat, PY - 2019/7/11/entrez PY - 2019/7/11/pubmed PY - 2019/9/17/medline SP - 157 EP - 161 JF - Psychiatria Danubina JO - Psychiatr Danub VL - 31 IS - 2 N2 - Schizophrenia and bipolar disorders are serious psychiatric disorders with substantial health risks. Asenapine is a new second-generation antipsychotic, available as a sublingual tablet, approved in Europe for the treatment of moderate-to-severe manic episodes in adults, and in US for manic or mixed episodes of bipolar I disorder in adults and adolescents. In this review, we searched the available literature to appreciate the role of asenapine in the management of psychiatric conditions such as bipolar disorders and schizophrenia and describe its mechanism of action, efficacy and tolerability. Asenapine has demonstrated efficacy in the management of bipolar disorders and schizophrenia, while a possible role in the management of borderline personality disorder and agitation needs further research. Asenapine has favourable side effects profile and combining with other pharmacological treatment in post-traumatic stress disorder has shown promising results. Asenapine fulfils important requirements of efficacy and tolerability as an anti-psychotic. These findings should support psychiatrists and pharmacists in the care of their patients while on asenapine. SN - 0353-5053 UR - https://www.unboundmedicine.com/medline/citation/31291219/Asenapine:_Pharmacological_Aspects_and_Role_in_Psychiatric_Disorders L2 - http://www.psychiatria-danubina.com/UserDocsImages/pdf/dnb_vol31_no2/dnb_vol31_no2_157.pdf DB - PRIME DP - Unbound Medicine ER -