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Pathogens distribution and drug resistance in patients with acute cerebral infarction complicated with diabetes and nosocomial pulmonary infection.
BMC Infect Dis 2019; 19(1):603BI

Abstract

BACKGROUND

This study aims to investigate the pathogen distribution and drug resistance in patients with acute cerebral infarction complicated with diabetes mellitus and nosocomial pulmonary infection.

METHODS

From August 2015 to December 2017, 172 pathogenic bacterial strains from patients with acute cerebral infarction complicated with diabetes mellitus and nosocomial pulmonary infection in our hospital were identified, and the drug sensitivity was analyzed.

RESULTS

Among these 172 strains of pathogenic bacteria, gram negative bacteria was the main cause of pulmonary infection in hospitalized patients with acute cerebral infarction, accounting for 75.6% of all pathogens. Furthermore, 80% of diabetic patients with cerebral infarction had lung infection induced by gram negative bacteria, which was significantly higher than that in non-diabetic patients (72.2%). Moreover, the drug resistance rate in the diabetic group (68.3%) was significantly higher than that in the non-diabetic group (54.3%). Gram positive bacteria accounted for 19.1% of all pathogenic bacteria. The infection rate of gram-positive bacteria in diabetic patients with cerebral infarction was 14.7%, which was lower than that in the non-diabetic group (22.6%). The drug-resistance rate was higher in the diabetic group (45.5%) than in the non-diabetic group (28.2%). Furthermore, the fungal infection rate in patients with lung infection in these two groups was 5.3 and 5.2%, respectively, and fungi presented with high sensitivity to commonly used antifungal agents.

CONCLUSION

In patients with acute cerebral infarction complicated with diabetes mellitus and nosocomial pulmonary infection, the majority of pathogens are multidrug-resistant gram negative bacilli. Pathogen culture should be conducted as soon as possible before using antibiotics, and antimicrobial agents should be reasonably used according to drug sensitivity test results.

Authors+Show Affiliations

Department of Emergency at Beijing Tongren Hospital of Capital Medical University, Beijing, 100176, China.Department of Emergency at Beijing Tongren Hospital of Capital Medical University, Beijing, 100176, China. caoqiumei89@163.com.Department of General Medicine at Beijing Tongren Hospital of Capital Medical University, No. 2 of Western South Road of Yizhuang, Daxing District, Beijing, 100176, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31291896

Citation

Liu, Yu-Xin, et al. "Pathogens Distribution and Drug Resistance in Patients With Acute Cerebral Infarction Complicated With Diabetes and Nosocomial Pulmonary Infection." BMC Infectious Diseases, vol. 19, no. 1, 2019, p. 603.
Liu YX, Cao QM, Ma BC. Pathogens distribution and drug resistance in patients with acute cerebral infarction complicated with diabetes and nosocomial pulmonary infection. BMC Infect Dis. 2019;19(1):603.
Liu, Y. X., Cao, Q. M., & Ma, B. C. (2019). Pathogens distribution and drug resistance in patients with acute cerebral infarction complicated with diabetes and nosocomial pulmonary infection. BMC Infectious Diseases, 19(1), p. 603. doi:10.1186/s12879-019-4142-9.
Liu YX, Cao QM, Ma BC. Pathogens Distribution and Drug Resistance in Patients With Acute Cerebral Infarction Complicated With Diabetes and Nosocomial Pulmonary Infection. BMC Infect Dis. 2019 Jul 10;19(1):603. PubMed PMID: 31291896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogens distribution and drug resistance in patients with acute cerebral infarction complicated with diabetes and nosocomial pulmonary infection. AU - Liu,Yu-Xin, AU - Cao,Qiu-Mei, AU - Ma,Bing-Chen, Y1 - 2019/07/10/ PY - 2018/12/04/received PY - 2019/05/29/accepted PY - 2019/7/12/entrez PY - 2019/7/12/pubmed PY - 2019/7/12/medline KW - Acute cerebral infarction KW - Diabetes mellitus(DM) KW - Drug-resistance KW - Pathogen KW - Pulmonary infection SP - 603 EP - 603 JF - BMC infectious diseases JO - BMC Infect. Dis. VL - 19 IS - 1 N2 - BACKGROUND: This study aims to investigate the pathogen distribution and drug resistance in patients with acute cerebral infarction complicated with diabetes mellitus and nosocomial pulmonary infection. METHODS: From August 2015 to December 2017, 172 pathogenic bacterial strains from patients with acute cerebral infarction complicated with diabetes mellitus and nosocomial pulmonary infection in our hospital were identified, and the drug sensitivity was analyzed. RESULTS: Among these 172 strains of pathogenic bacteria, gram negative bacteria was the main cause of pulmonary infection in hospitalized patients with acute cerebral infarction, accounting for 75.6% of all pathogens. Furthermore, 80% of diabetic patients with cerebral infarction had lung infection induced by gram negative bacteria, which was significantly higher than that in non-diabetic patients (72.2%). Moreover, the drug resistance rate in the diabetic group (68.3%) was significantly higher than that in the non-diabetic group (54.3%). Gram positive bacteria accounted for 19.1% of all pathogenic bacteria. The infection rate of gram-positive bacteria in diabetic patients with cerebral infarction was 14.7%, which was lower than that in the non-diabetic group (22.6%). The drug-resistance rate was higher in the diabetic group (45.5%) than in the non-diabetic group (28.2%). Furthermore, the fungal infection rate in patients with lung infection in these two groups was 5.3 and 5.2%, respectively, and fungi presented with high sensitivity to commonly used antifungal agents. CONCLUSION: In patients with acute cerebral infarction complicated with diabetes mellitus and nosocomial pulmonary infection, the majority of pathogens are multidrug-resistant gram negative bacilli. Pathogen culture should be conducted as soon as possible before using antibiotics, and antimicrobial agents should be reasonably used according to drug sensitivity test results. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/31291896/Pathogens_distribution_and_drug_resistance_in_patients_with_acute_cerebral_infarction_complicated_with_diabetes_and_nosocomial_pulmonary_infection L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-4142-9 DB - PRIME DP - Unbound Medicine ER -