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The effects of naringin on different cyclophosphamide-induced organ toxicities in rats: investigation of changes in some metabolic enzyme activities.
Environ Sci Pollut Res Int. 2019 Sep; 26(26):26664-26673.ES

Abstract

Cyclophosphamide (CYP) is a common anticancer drug used in the treatment of various malignancies. Naringin (NG) is a natural bioflavonoid that have been reported to have many medicinal and pharmacological properties. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase (CA), α-glycosidase (α-Gly), and aldose reductase (AR) enzymes are the essential biological molecules needed for metabolic processes in all living cells. In the present study, the aim was to investigate the effect of NG against CYP-induced liver, brain, kidney, heart, and testis toxicities on some metabolic enzyme activities such as AChE, BChE, CA, α-Gly, and AR. Thirty-five male Wistar rats were randomly divided into five groups with each group consisting of seven rats. The rats were subjected to oral treatment of NG (50 and 100 mg/kg body weight) for 7 days before administering a single dose of CYP (200 mg/kg body weight, i.p) on the seventh day. Treatment with NG in all tissues regulated these enzyme activities in CYP-induced rats. The results of this study showed that NG regulates abnormal increases and decreases in CYP-induced metabolic enzyme activities in all tissues.

Authors+Show Affiliations

Faculty of Veterinary Medicine, Department of Biochemistry, Bingol University, 12000, Bingol, Turkey. ccaglayan@bingol.edu.tr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31292874

Citation

Caglayan, Cuneyt. "The Effects of Naringin On Different Cyclophosphamide-induced Organ Toxicities in Rats: Investigation of Changes in some Metabolic Enzyme Activities." Environmental Science and Pollution Research International, vol. 26, no. 26, 2019, pp. 26664-26673.
Caglayan C. The effects of naringin on different cyclophosphamide-induced organ toxicities in rats: investigation of changes in some metabolic enzyme activities. Environ Sci Pollut Res Int. 2019;26(26):26664-26673.
Caglayan, C. (2019). The effects of naringin on different cyclophosphamide-induced organ toxicities in rats: investigation of changes in some metabolic enzyme activities. Environmental Science and Pollution Research International, 26(26), 26664-26673. https://doi.org/10.1007/s11356-019-05915-3
Caglayan C. The Effects of Naringin On Different Cyclophosphamide-induced Organ Toxicities in Rats: Investigation of Changes in some Metabolic Enzyme Activities. Environ Sci Pollut Res Int. 2019;26(26):26664-26673. PubMed PMID: 31292874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of naringin on different cyclophosphamide-induced organ toxicities in rats: investigation of changes in some metabolic enzyme activities. A1 - Caglayan,Cuneyt, Y1 - 2019/07/10/ PY - 2019/05/23/received PY - 2019/07/03/accepted PY - 2019/7/12/pubmed PY - 2019/11/14/medline PY - 2019/7/12/entrez KW - Acetylcholinesterase KW - Aldose reductase KW - Butyrylcholinesterase KW - Carbonic anhydrase KW - Cyclophosphamide KW - Naringin SP - 26664 EP - 26673 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 26 IS - 26 N2 - Cyclophosphamide (CYP) is a common anticancer drug used in the treatment of various malignancies. Naringin (NG) is a natural bioflavonoid that have been reported to have many medicinal and pharmacological properties. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase (CA), α-glycosidase (α-Gly), and aldose reductase (AR) enzymes are the essential biological molecules needed for metabolic processes in all living cells. In the present study, the aim was to investigate the effect of NG against CYP-induced liver, brain, kidney, heart, and testis toxicities on some metabolic enzyme activities such as AChE, BChE, CA, α-Gly, and AR. Thirty-five male Wistar rats were randomly divided into five groups with each group consisting of seven rats. The rats were subjected to oral treatment of NG (50 and 100 mg/kg body weight) for 7 days before administering a single dose of CYP (200 mg/kg body weight, i.p) on the seventh day. Treatment with NG in all tissues regulated these enzyme activities in CYP-induced rats. The results of this study showed that NG regulates abnormal increases and decreases in CYP-induced metabolic enzyme activities in all tissues. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/31292874/The_effects_of_naringin_on_different_cyclophosphamide_induced_organ_toxicities_in_rats:_investigation_of_changes_in_some_metabolic_enzyme_activities_ L2 - https://dx.doi.org/10.1007/s11356-019-05915-3 DB - PRIME DP - Unbound Medicine ER -