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Inverse associations of bisphenol A and phthalate metabolites with serum bilirubin levels in Korean population.
Environ Sci Pollut Res Int. 2019 Sep; 26(26):26685-26695.ES

Abstract

Bisphenol A (BPA) and phthalates are endocrine disruptors that can induce oxidative stress. Serum bilirubin has antioxidant properties and may serve as a biomarker of oxidative stress. The objective of this study was to explore the relationship of BPA and phthalates with serum bilirubin levels in a Korean population. Urinary concentrations of BPA and six phthalate [mono-n-butyl phthalate (MnBP), mono-iso-butyl phthalate (MiBP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(2-ethyl-5- hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), and mono-benzyl phthalate (MBzP)] were measured in 709 participants. Serum concentrations of BPA and three phthalate metabolites [MnBP, MiBP, and mono-(2-ethylhexyl) phthalate (MEHP)] were measured in 752 participants. After excluding missing variables, associations between above chemicals and serum bilirubin levels were analyzed using multivariate linear regression with age, sex, BMI, GGT, GOT, GPT, and alcohol intake adjustment. Participants were further stratified by sex. Among the urinary chemicals, BPA and four phthalate metabolites (MnBP, MEOHP, MEHHP and MECPP) were inversely associated with serum bilirubin levels (BPA: β = - 0.071, P < 0.0001; MnBP: β = - 0.055, P = 0.025; MEOHP: β = - 0.101, P < 0.0001; MEHHP: β = - 0.106, P < 0.0001; MECPP: β = - 0.052, P = 0.003). In a case of serum chemicals, only MiBP showed significantly positive association (β = 0.036, P = 0.016). After stratification by sex, the associations of urinary BPA remained both in male and female, of which urinary phthalates disappeared in female. The association of serum MiBP was disappeared after stratification. Urinary BPA and phthalate metabolites were inversely associated with serum bilirubin levels, whereas serum MiBP showed positive association with bilirubin. These results could provide clues for understanding the mechanisms of endocrine disruptor from oxidative stress to excretion from our body.

Authors+Show Affiliations

Department of Public Health, Graduate School, Yonsei University, Seoul, 03722, South Korea. Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, 03722, South Korea.Department of Public Health, Graduate School, Yonsei University, Seoul, 03722, South Korea. Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, 03722, South Korea.Department of Public Health, Graduate School, Yonsei University, Seoul, 03722, South Korea. Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, 03722, South Korea.Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, 03722, South Korea.Department of Public Health, Graduate School, Yonsei University, Seoul, 03722, South Korea. jsunha@yuhs.ac. Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, 03722, South Korea. jsunha@yuhs.ac.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31292880

Citation

Choi, Yoonjeong, et al. "Inverse Associations of Bisphenol a and Phthalate Metabolites With Serum Bilirubin Levels in Korean Population." Environmental Science and Pollution Research International, vol. 26, no. 26, 2019, pp. 26685-26695.
Choi Y, Lee SJ, Jeon J, et al. Inverse associations of bisphenol A and phthalate metabolites with serum bilirubin levels in Korean population. Environ Sci Pollut Res Int. 2019;26(26):26685-26695.
Choi, Y., Lee, S. J., Jeon, J., Jung, K. J., & Jee, S. H. (2019). Inverse associations of bisphenol A and phthalate metabolites with serum bilirubin levels in Korean population. Environmental Science and Pollution Research International, 26(26), 26685-26695. https://doi.org/10.1007/s11356-019-05205-y
Choi Y, et al. Inverse Associations of Bisphenol a and Phthalate Metabolites With Serum Bilirubin Levels in Korean Population. Environ Sci Pollut Res Int. 2019;26(26):26685-26695. PubMed PMID: 31292880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inverse associations of bisphenol A and phthalate metabolites with serum bilirubin levels in Korean population. AU - Choi,Yoonjeong, AU - Lee,Sun Ju, AU - Jeon,Jooeun, AU - Jung,Keum Ji, AU - Jee,Sun Ha, Y1 - 2019/07/11/ PY - 2018/09/11/received PY - 2019/04/15/accepted PY - 2019/7/12/pubmed PY - 2019/11/26/medline PY - 2019/7/12/entrez KW - Bilirubin KW - Bisphenol KW - Endocrine disruptors KW - Inverse association KW - Linear models KW - Phthalate SP - 26685 EP - 26695 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 26 IS - 26 N2 - Bisphenol A (BPA) and phthalates are endocrine disruptors that can induce oxidative stress. Serum bilirubin has antioxidant properties and may serve as a biomarker of oxidative stress. The objective of this study was to explore the relationship of BPA and phthalates with serum bilirubin levels in a Korean population. Urinary concentrations of BPA and six phthalate [mono-n-butyl phthalate (MnBP), mono-iso-butyl phthalate (MiBP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(2-ethyl-5- hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), and mono-benzyl phthalate (MBzP)] were measured in 709 participants. Serum concentrations of BPA and three phthalate metabolites [MnBP, MiBP, and mono-(2-ethylhexyl) phthalate (MEHP)] were measured in 752 participants. After excluding missing variables, associations between above chemicals and serum bilirubin levels were analyzed using multivariate linear regression with age, sex, BMI, GGT, GOT, GPT, and alcohol intake adjustment. Participants were further stratified by sex. Among the urinary chemicals, BPA and four phthalate metabolites (MnBP, MEOHP, MEHHP and MECPP) were inversely associated with serum bilirubin levels (BPA: β = - 0.071, P < 0.0001; MnBP: β = - 0.055, P = 0.025; MEOHP: β = - 0.101, P < 0.0001; MEHHP: β = - 0.106, P < 0.0001; MECPP: β = - 0.052, P = 0.003). In a case of serum chemicals, only MiBP showed significantly positive association (β = 0.036, P = 0.016). After stratification by sex, the associations of urinary BPA remained both in male and female, of which urinary phthalates disappeared in female. The association of serum MiBP was disappeared after stratification. Urinary BPA and phthalate metabolites were inversely associated with serum bilirubin levels, whereas serum MiBP showed positive association with bilirubin. These results could provide clues for understanding the mechanisms of endocrine disruptor from oxidative stress to excretion from our body. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/31292880/Inverse_associations_of_bisphenol_A_and_phthalate_metabolites_with_serum_bilirubin_levels_in_Korean_population_ L2 - https://dx.doi.org/10.1007/s11356-019-05205-y DB - PRIME DP - Unbound Medicine ER -