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Effect of aging on behaviour of mesenchymal stem cells.
World J Stem Cells 2019; 11(6):337-346WJ

Abstract

Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult stem cells, called "mesenchymal stem cells" or "mesenchymal stromal cells (MSCs)", contributes directly to the homeostatic maintenance of their organs; hence, their senescence could be very deleterious for human bodily functions. MSCs are easily isolated and amenable their expansion in vitro because of the research demanding to test them in many diverse clinical indications. All of these works are shown by the rapidly expanding literature that includes many in vivo animal models. We do not have an in-depth understanding of mechanisms that induce cellular senescence, and to further clarify the consequences of the senescence process in MSCs, some hints may be derived from the study of cellular behaviour in vivo and in vitro, autophagy, mitochondrial stress and exosomal activity. In this particular work, we decided to review these biological features in the literature on MSC senescence over the last three years.

Authors+Show Affiliations

Grupo de Terapia Celular y Medicina Regenerativa, Departamento de Fisioterapia, Ciencias Biomédicas y Medicina, Universidade da Coruña, A Coruña 15006, Spain.Grupo de Terapia Celular y Medicina Regenerativa, Departamento de Fisioterapia, Ciencias Biomédicas y Medicina, Universidade da Coruña, A Coruña 15006, Spain.Grupo de Terapia Celular y Medicina Regenerativa, Departamento de Fisioterapia, Ciencias Biomédicas y Medicina, Universidade da Coruña, A Coruña 15006, Spain. maria.arufe@udc.es.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31293716

Citation

Fafián-Labora, Juan Antonio, et al. "Effect of Aging On Behaviour of Mesenchymal Stem Cells." World Journal of Stem Cells, vol. 11, no. 6, 2019, pp. 337-346.
Fafián-Labora JA, Morente-López M, Arufe MC. Effect of aging on behaviour of mesenchymal stem cells. World J Stem Cells. 2019;11(6):337-346.
Fafián-Labora, J. A., Morente-López, M., & Arufe, M. C. (2019). Effect of aging on behaviour of mesenchymal stem cells. World Journal of Stem Cells, 11(6), pp. 337-346. doi:10.4252/wjsc.v11.i6.337.
Fafián-Labora JA, Morente-López M, Arufe MC. Effect of Aging On Behaviour of Mesenchymal Stem Cells. World J Stem Cells. 2019 Jun 26;11(6):337-346. PubMed PMID: 31293716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of aging on behaviour of mesenchymal stem cells. AU - Fafián-Labora,Juan Antonio, AU - Morente-López,Miriam, AU - Arufe,María C, PY - 2019/02/23/received PY - 2019/03/29/revised PY - 2019/05/06/accepted PY - 2019/7/12/entrez PY - 2019/7/12/pubmed PY - 2019/7/12/medline KW - Aging KW - Autophagy KW - Extracellular vesicles KW - Mesenchymal stem cells KW - Mitochondrial stress SP - 337 EP - 346 JF - World journal of stem cells JO - World J Stem Cells VL - 11 IS - 6 N2 - Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult stem cells, called "mesenchymal stem cells" or "mesenchymal stromal cells (MSCs)", contributes directly to the homeostatic maintenance of their organs; hence, their senescence could be very deleterious for human bodily functions. MSCs are easily isolated and amenable their expansion in vitro because of the research demanding to test them in many diverse clinical indications. All of these works are shown by the rapidly expanding literature that includes many in vivo animal models. We do not have an in-depth understanding of mechanisms that induce cellular senescence, and to further clarify the consequences of the senescence process in MSCs, some hints may be derived from the study of cellular behaviour in vivo and in vitro, autophagy, mitochondrial stress and exosomal activity. In this particular work, we decided to review these biological features in the literature on MSC senescence over the last three years. SN - 1948-0210 UR - https://www.unboundmedicine.com/medline/citation/31293716/Effect_of_aging_on_behaviour_of_mesenchymal_stem_cells L2 - http://www.wjgnet.com/1948-0210/full/v11/i6/337.htm DB - PRIME DP - Unbound Medicine ER -