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The contact pathway and sepsis.
Res Pract Thromb Haemost 2019; 3(3):331-339RP

Abstract

The contact pathway factors XI (FXI) and XII (FXII) have been demonstrated to be largely dispensable for hemostasis, as their absence results in a mild to absent bleeding diathesis. A growing body of literature, however, suggests that the contact pathway contributes to the pathologic host response to certain infectious organisms that produces the often-fatal syndrome known as sepsis. The contact pathway factors serve as a central node connecting inflammation to coagulation, and may offer a potentially safe therapeutic target to mitigate the morbidity and mortality associated with sepsis. Herein, we summarize published in vivo and in vitro data that have explored the roles of the contact pathway in sepsis, and discuss potential clinical applications of novel FXI- and FXII-inhibiting drugs currently under investigation.

Authors+Show Affiliations

Division of Hematology-Medical Oncology Knight Cancer Institute Oregon Health & Science University Portland Oregon USA.Department of Biomedical Engineering Oregon Health & Science University Portland Oregon USA.Division of Hematology-Medical Oncology Knight Cancer Institute Oregon Health & Science University Portland Oregon USA. Department of Biomedical Engineering Oregon Health & Science University Portland Oregon USA.Cardiovascular Biology Research Program Oklahoma Medical Research Foundation Oklahoma City Oklahoma USA.Department of Biomedical Engineering Oregon Health & Science University Portland Oregon USA.Division of Hematology-Medical Oncology Knight Cancer Institute Oregon Health & Science University Portland Oregon USA. Department of Biomedical Engineering Oregon Health & Science University Portland Oregon USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31294319

Citation

Raghunathan, Vikram, et al. "The Contact Pathway and Sepsis." Research and Practice in Thrombosis and Haemostasis, vol. 3, no. 3, 2019, pp. 331-339.
Raghunathan V, Zilberman-Rudenko J, Olson SR, et al. The contact pathway and sepsis. Res Pract Thromb Haemost. 2019;3(3):331-339.
Raghunathan, V., Zilberman-Rudenko, J., Olson, S. R., Lupu, F., McCarty, O. J. T., & Shatzel, J. J. (2019). The contact pathway and sepsis. Research and Practice in Thrombosis and Haemostasis, 3(3), pp. 331-339. doi:10.1002/rth2.12217.
Raghunathan V, et al. The Contact Pathway and Sepsis. Res Pract Thromb Haemost. 2019;3(3):331-339. PubMed PMID: 31294319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The contact pathway and sepsis. AU - Raghunathan,Vikram, AU - Zilberman-Rudenko,Jevgenia, AU - Olson,Sven R, AU - Lupu,Florea, AU - McCarty,Owen J T, AU - Shatzel,Joseph J, Y1 - 2019/05/23/ PY - 2019/03/19/received PY - 2019/04/15/accepted PY - 2019/7/12/entrez PY - 2019/7/12/pubmed PY - 2019/7/12/medline KW - contact activation KW - factor XI KW - factor XII KW - kallikrein‐kinin system KW - sepsis SP - 331 EP - 339 JF - Research and practice in thrombosis and haemostasis JO - Res Pract Thromb Haemost VL - 3 IS - 3 N2 - The contact pathway factors XI (FXI) and XII (FXII) have been demonstrated to be largely dispensable for hemostasis, as their absence results in a mild to absent bleeding diathesis. A growing body of literature, however, suggests that the contact pathway contributes to the pathologic host response to certain infectious organisms that produces the often-fatal syndrome known as sepsis. The contact pathway factors serve as a central node connecting inflammation to coagulation, and may offer a potentially safe therapeutic target to mitigate the morbidity and mortality associated with sepsis. Herein, we summarize published in vivo and in vitro data that have explored the roles of the contact pathway in sepsis, and discuss potential clinical applications of novel FXI- and FXII-inhibiting drugs currently under investigation. SN - 2475-0379 UR - https://www.unboundmedicine.com/medline/citation/31294319/The_contact_pathway_and_sepsis L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31294319/ DB - PRIME DP - Unbound Medicine ER -