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Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.
Science 2019; 365(6449)Sci

Abstract

To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.

Authors+Show Affiliations

Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.Division of Comparative Medicine, Washington University, St. Louis, MO 63110, USA.Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique and Aix-Marseille Université, 13288 Marseille cedex 9, France. Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA.Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA.Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA. Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA. Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA. Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. Genome Technology Access Center, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. Genome Technology Access Center, Washington University School of Medicine, St. Louis, MO 63110, USA.A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia. Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia. Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia. Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. jgordon@wustl.edu. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31296738

Citation

Gehrig, Jeanette L., et al. "Effects of Microbiota-directed Foods in Gnotobiotic Animals and Undernourished Children." Science (New York, N.Y.), vol. 365, no. 6449, 2019.
Gehrig JL, Venkatesh S, Chang HW, et al. Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. Science. 2019;365(6449).
Gehrig, J. L., Venkatesh, S., Chang, H. W., Hibberd, M. C., Kung, V. L., Cheng, J., ... Gordon, J. I. (2019). Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. Science (New York, N.Y.), 365(6449), doi:10.1126/science.aau4732.
Gehrig JL, et al. Effects of Microbiota-directed Foods in Gnotobiotic Animals and Undernourished Children. Science. 2019 07 12;365(6449) PubMed PMID: 31296738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. AU - Gehrig,Jeanette L, AU - Venkatesh,Siddarth, AU - Chang,Hao-Wei, AU - Hibberd,Matthew C, AU - Kung,Vanderlene L, AU - Cheng,Jiye, AU - Chen,Robert Y, AU - Subramanian,Sathish, AU - Cowardin,Carrie A, AU - Meier,Martin F, AU - O'Donnell,David, AU - Talcott,Michael, AU - Spears,Larry D, AU - Semenkovich,Clay F, AU - Henrissat,Bernard, AU - Giannone,Richard J, AU - Hettich,Robert L, AU - Ilkayeva,Olga, AU - Muehlbauer,Michael, AU - Newgard,Christopher B, AU - Sawyer,Christopher, AU - Head,Richard D, AU - Rodionov,Dmitry A, AU - Arzamasov,Aleksandr A, AU - Leyn,Semen A, AU - Osterman,Andrei L, AU - Hossain,Md Iqbal, AU - Islam,Munirul, AU - Choudhury,Nuzhat, AU - Sarker,Shafiqul Alam, AU - Huq,Sayeeda, AU - Mahmud,Imteaz, AU - Mostafa,Ishita, AU - Mahfuz,Mustafa, AU - Barratt,Michael J, AU - Ahmed,Tahmeed, AU - Gordon,Jeffrey I, PY - 2018/06/13/received PY - 2019/04/24/revised PY - 2019/06/07/accepted PY - 2019/7/13/entrez PY - 2019/7/13/pubmed PY - 2019/7/13/medline JF - Science (New York, N.Y.) JO - Science VL - 365 IS - 6449 N2 - To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/31296738/Effects_of_microbiota-directed_foods_in_gnotobiotic_animals_and_undernourished_children L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=31296738 DB - PRIME DP - Unbound Medicine ER -