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Young patient with treatment-resistant schizophrenia drastically improved by combination of clozapine and maintenance electroconvulsive therapy: a case report.
Int Med Case Rep J. 2019; 12:185-188.IM

Abstract

Objectives:

Although clozapine is considered the only effective pharmacological option for patients with treatment-resistant schizophrenia (TRS), around 30-40% of patients show clozapine resistance. Modified electroconvulsive therapy augmentation is reportedly clinically effective for clozapine-resistant schizophrenia, but few case reports have described the efficacy of combining clozapine and continuous/maintenance ECT for patients with TRS.

Methods:

We present the case of a young patient with TRS who was treated using combination therapy with clozapine and maintenance ECT (m-ECT).

Results:

The patient achieved drastic improvement under combination therapy with clozapine and m-ECT. Total Positive and Negative Syndrome Scale (PANSS) score fell markedly by 36 (from 108 to 72) using the combination of clozapine and m-ECT. Behaviors not reflected directly by PANSS score also improved. For example, the problem of being unable to take oral drugs stably because of delusions of poisoning was resolved. Furthermore, the patient maintained improvement under m-ECT, and long-term homestays became possible.

Conclusion:

Combination therapy with clozapine and m-ECT proved greatly effective in this case. Further clinical trials of this combination therapy for TRS are needed to confirm the effectiveness. Further studies are also expected to examine effective periods for this therapy.

Authors+Show Affiliations

Department of Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan.Department of Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan. Department of Neuropsychiatry, Fukushima Medical University School of Aizu Medical Center, Fukushima, Japan.Department of Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan.Department of Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan.Department of Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan.Department of Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan.Department of Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31297000

Citation

Ito, Masashi, et al. "Young Patient With Treatment-resistant Schizophrenia Drastically Improved By Combination of Clozapine and Maintenance Electroconvulsive Therapy: a Case Report." International Medical Case Reports Journal, vol. 12, 2019, pp. 185-188.
Ito M, Kunii Y, Horikoshi S, et al. Young patient with treatment-resistant schizophrenia drastically improved by combination of clozapine and maintenance electroconvulsive therapy: a case report. Int Med Case Rep J. 2019;12:185-188.
Ito, M., Kunii, Y., Horikoshi, S., Miura, I., Itagaki, S., Shiga, T., & Yabe, H. (2019). Young patient with treatment-resistant schizophrenia drastically improved by combination of clozapine and maintenance electroconvulsive therapy: a case report. International Medical Case Reports Journal, 12, 185-188. https://doi.org/10.2147/IMCRJ.S198124
Ito M, et al. Young Patient With Treatment-resistant Schizophrenia Drastically Improved By Combination of Clozapine and Maintenance Electroconvulsive Therapy: a Case Report. Int Med Case Rep J. 2019;12:185-188. PubMed PMID: 31297000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Young patient with treatment-resistant schizophrenia drastically improved by combination of clozapine and maintenance electroconvulsive therapy: a case report. AU - Ito,Masashi, AU - Kunii,Yasuto, AU - Horikoshi,Sho, AU - Miura,Itaru, AU - Itagaki,Shuntaro, AU - Shiga,Tetsuya, AU - Yabe,Hirooki, Y1 - 2019/06/21/ PY - 2018/12/13/received PY - 2019/04/03/accepted PY - 2019/7/13/entrez PY - 2019/7/13/pubmed PY - 2019/7/13/medline KW - augmentation KW - clozapine KW - maintenance ECT(m-ECT) KW - modified electroconvulsive therapy KW - treatment-resistant schizophrenia (TRS) SP - 185 EP - 188 JF - International medical case reports journal JO - Int Med Case Rep J VL - 12 N2 - Objectives: Although clozapine is considered the only effective pharmacological option for patients with treatment-resistant schizophrenia (TRS), around 30-40% of patients show clozapine resistance. Modified electroconvulsive therapy augmentation is reportedly clinically effective for clozapine-resistant schizophrenia, but few case reports have described the efficacy of combining clozapine and continuous/maintenance ECT for patients with TRS. Methods: We present the case of a young patient with TRS who was treated using combination therapy with clozapine and maintenance ECT (m-ECT). Results: The patient achieved drastic improvement under combination therapy with clozapine and m-ECT. Total Positive and Negative Syndrome Scale (PANSS) score fell markedly by 36 (from 108 to 72) using the combination of clozapine and m-ECT. Behaviors not reflected directly by PANSS score also improved. For example, the problem of being unable to take oral drugs stably because of delusions of poisoning was resolved. Furthermore, the patient maintained improvement under m-ECT, and long-term homestays became possible. Conclusion: Combination therapy with clozapine and m-ECT proved greatly effective in this case. Further clinical trials of this combination therapy for TRS are needed to confirm the effectiveness. Further studies are also expected to examine effective periods for this therapy. SN - 1179-142X UR - https://www.unboundmedicine.com/medline/citation/31297000/Young_patient_with_treatment_resistant_schizophrenia_drastically_improved_by_combination_of_clozapine_and_maintenance_electroconvulsive_therapy:_a_case_report_ L2 - https://dx.doi.org/10.2147/IMCRJ.S198124 DB - PRIME DP - Unbound Medicine ER -
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