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17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil.
Emerg Infect Dis. 2019 08; 25(8):1511-1521.EI

Abstract

We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine-specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-γ+CD8+ T cells, 10 years after primary vaccination. Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-γ+CD8+ T cells. Moreover, secondary or multiple vaccinations guarantee long-term persistence of PRNT positivity and cell-mediated memory 10 years after booster vaccination. These findings support the relevance of booster doses to heighten the 17DD-YF-specific immune response to guarantee the long-term persistence of memory components. Secondary or multiple vaccinations improved the correlates of protection triggered by 17DD-YF primary vaccination, indicating that booster regimens are needed to achieve efficient immunity in areas with high risk for virus transmission.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31298654

Citation

Campi-Azevedo, Ana Carolina, et al. "17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil." Emerging Infectious Diseases, vol. 25, no. 8, 2019, pp. 1511-1521.
Campi-Azevedo AC, Peruhype-Magalhāes V, Coelho-Dos-Reis JG, et al. 17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil. Emerg Infect Dis. 2019;25(8):1511-1521.
Campi-Azevedo, A. C., Peruhype-Magalhāes, V., Coelho-Dos-Reis, J. G., Antonelli, L. R., Costa-Pereira, C., Speziali, E., Reis, L. R., Lemos, J. A., Ribeiro, J. G. L., Bastos Camacho, L. A., de Sousa Maia, M. L., Barbosa de Lima, S. M., Simões, M., de Menezes Martins, R., Homma, A., Cota Malaquias, L. C., Tauil, P. L., Costa Vasconcelos, P. F., Martins Romano, A. P., ... Martins-Filho, O. A. (2019). 17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil. Emerging Infectious Diseases, 25(8), 1511-1521. https://doi.org/10.3201/eid2508.181432
Campi-Azevedo AC, et al. 17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil. Emerg Infect Dis. 2019;25(8):1511-1521. PubMed PMID: 31298654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil. AU - Campi-Azevedo,Ana Carolina, AU - Peruhype-Magalhāes,Vanessa, AU - Coelho-Dos-Reis,Jordana Grazziela, AU - Antonelli,Lis Ribeiro, AU - Costa-Pereira,Christiane, AU - Speziali,Elaine, AU - Reis,Laise Rodrigues, AU - Lemos,Jandira Aparecida, AU - Ribeiro,José Geraldo Leite, AU - Bastos Camacho,Luiz Antônio, AU - de Sousa Maia,Maria de Lourdes, AU - Barbosa de Lima,Sheila Maria, AU - Simões,Marisol, AU - de Menezes Martins,Reinaldo, AU - Homma,Akira, AU - Cota Malaquias,Luiz Cosme, AU - Tauil,Pedro Luiz, AU - Costa Vasconcelos,Pedro Fernando, AU - Martins Romano,Alessandro Pecego, AU - Domingues,Carla Magda, AU - Teixeira-Carvalho,Andréa, AU - Martins-Filho,Olindo Assis, AU - ,, Y1 - 2019/08/17/ PY - 2019/7/13/pubmed PY - 2019/12/24/medline PY - 2019/7/13/entrez KW - 17DD vaccine KW - Brazil KW - memory CD8+ T-cells KW - neutralizing antibodies KW - vector-borne infections KW - viruses KW - yellow fever SP - 1511 EP - 1521 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 25 IS - 8 N2 - We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine-specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-γ+CD8+ T cells, 10 years after primary vaccination. Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-γ+CD8+ T cells. Moreover, secondary or multiple vaccinations guarantee long-term persistence of PRNT positivity and cell-mediated memory 10 years after booster vaccination. These findings support the relevance of booster doses to heighten the 17DD-YF-specific immune response to guarantee the long-term persistence of memory components. Secondary or multiple vaccinations improved the correlates of protection triggered by 17DD-YF primary vaccination, indicating that booster regimens are needed to achieve efficient immunity in areas with high risk for virus transmission. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/31298654/17DD_Yellow_Fever_Revaccination_and_Heightened_Long_Term_Immunity_in_Populations_of_Disease_Endemic_Areas_Brazil_ L2 - https://doi.org/10.3201/eid2508.181432 DB - PRIME DP - Unbound Medicine ER -