Tags

Type your tag names separated by a space and hit enter

Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology.
Semin Nephrol 2019; 39(4):353-367SN

Abstract

The epithelium of the kidney collecting duct (CD) is composed mainly of two different types of cells with distinct and complementary functions. CD principal cells traditionally have been considered to have a major role in Na+ and water regulation, while intercalated cells (ICs) were thought to largely modulate acid-base homeostasis. In recent years, our understanding of IC function has improved significantly owing to new research findings. Thus, we now have a new model for CD transport that integrates mechanisms of salt and water reabsorption, K+ homeostasis, and acid-base status between principal cells and ICs. There are three main types of ICs (type A, type B, and non-A, non-B), which first appear in the late distal convoluted tubule or in the connecting segment in a species-dependent manner. ICs can be detected in CD from cortex to the initial part of the inner medulla, although some transport proteins that are key components of ICs also are present in medullary CD, cells considered inner medullary. Of the three types of ICs, each has a distinct morphology and expresses different complements of membrane transport proteins that translate into very different functions in homeostasis and contributions to CD luminal pro-urine composition. This review includes recent discoveries in IC intracellular and paracrine signaling that contributes to acid-base regulation as well as Na+, Cl-, K+, and Ca2+ homeostasis. Thus, these new findings highlight the potential role of ICs as targets for potential hypertension treatments.

Authors+Show Affiliations

University of Southern California/University Kidney Research Organization, Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA.Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.University of Southern California/University Kidney Research Organization, Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA. Electronic address: nuria.pastor-soler@med.usc.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31300091

Citation

Rao, Renee, et al. "Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology." Seminars in Nephrology, vol. 39, no. 4, 2019, pp. 353-367.
Rao R, Bhalla V, Pastor-Soler NM. Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology. Semin Nephrol. 2019;39(4):353-367.
Rao, R., Bhalla, V., & Pastor-Soler, N. M. (2019). Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology. Seminars in Nephrology, 39(4), pp. 353-367. doi:10.1016/j.semnephrol.2019.04.005.
Rao R, Bhalla V, Pastor-Soler NM. Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology. Semin Nephrol. 2019;39(4):353-367. PubMed PMID: 31300091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology. AU - Rao,Renee, AU - Bhalla,Vivek, AU - Pastor-Soler,Núria M, PY - 2020/07/01/pmc-release PY - 2019/7/14/entrez PY - 2019/7/14/pubmed PY - 2019/7/14/medline KW - Acidosis KW - acidemia KW - alkalemia KW - alkalosis KW - calcium KW - chloride KW - potassium KW - sodium SP - 353 EP - 367 JF - Seminars in nephrology JO - Semin. Nephrol. VL - 39 IS - 4 N2 - The epithelium of the kidney collecting duct (CD) is composed mainly of two different types of cells with distinct and complementary functions. CD principal cells traditionally have been considered to have a major role in Na+ and water regulation, while intercalated cells (ICs) were thought to largely modulate acid-base homeostasis. In recent years, our understanding of IC function has improved significantly owing to new research findings. Thus, we now have a new model for CD transport that integrates mechanisms of salt and water reabsorption, K+ homeostasis, and acid-base status between principal cells and ICs. There are three main types of ICs (type A, type B, and non-A, non-B), which first appear in the late distal convoluted tubule or in the connecting segment in a species-dependent manner. ICs can be detected in CD from cortex to the initial part of the inner medulla, although some transport proteins that are key components of ICs also are present in medullary CD, cells considered inner medullary. Of the three types of ICs, each has a distinct morphology and expresses different complements of membrane transport proteins that translate into very different functions in homeostasis and contributions to CD luminal pro-urine composition. This review includes recent discoveries in IC intracellular and paracrine signaling that contributes to acid-base regulation as well as Na+, Cl-, K+, and Ca2+ homeostasis. Thus, these new findings highlight the potential role of ICs as targets for potential hypertension treatments. SN - 1558-4488 UR - https://www.unboundmedicine.com/medline/citation/31300091/Intercalated_Cells_of_the_Kidney_Collecting_Duct_in_Kidney_Physiology L2 - https://linkinghub.elsevier.com/retrieve/pii/S0270-9295(19)30038-5 DB - PRIME DP - Unbound Medicine ER -