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Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance.
Semin Nephrol 2019; 39(4):394-405SN

Abstract

Ammonia metabolism has a critical role in acid-base homeostasis and in other cellular functions. Kidneys have a central role in bicarbonate generation, which occurs through the process of net acid excretion; ammonia metabolism is the quantitatively greatest component of net acid excretion, both under basal conditions and in response to acid-base disturbances. Several recent studies have advanced our understanding substantially of the molecular mechanisms and regulation of ammonia metabolism. First, the previous paradigm that ammonia transport could be explained by passive NH3 diffusion and NH4+ trapping has been advanced by the recognition that specific transport of NH3 and of NH4+ by specific membrane proteins is critical to ammonia transport. Second, significant advances have been made in the understanding of the regulation of ammonia metabolism. Novel studies have shown that hyperkalemia directly inhibits ammonia metabolism, thereby leading to the metabolic acidosis present in type IV renal tubular acidosis. Other studies have shown that the proximal tubule protein NBCe1, specifically the A variant NBCe1-A, has a major role in regulating renal ammonia metabolism. Third, there are important sex differences in ammonia metabolism that involve structural and functional differences in the kidney. This review addresses these important aspects of ammonia metabolism and transport.

Authors+Show Affiliations

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL; Nephrology and Hypertension Section, Gainesville Veterans Affairs Medical Center, Gainesville, FL. Electronic address: david.weiner@medicine.ufl.edu.Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31300094

Citation

Weiner, I David, and Jill W. Verlander. "Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance." Seminars in Nephrology, vol. 39, no. 4, 2019, pp. 394-405.
Weiner ID, Verlander JW. Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance. Semin Nephrol. 2019;39(4):394-405.
Weiner, I. D., & Verlander, J. W. (2019). Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance. Seminars in Nephrology, 39(4), pp. 394-405. doi:10.1016/j.semnephrol.2019.04.008.
Weiner ID, Verlander JW. Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance. Semin Nephrol. 2019;39(4):394-405. PubMed PMID: 31300094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance. AU - Weiner,I David, AU - Verlander,Jill W, PY - 2020/07/01/pmc-release PY - 2019/7/14/entrez PY - 2019/7/14/pubmed PY - 2019/7/14/medline KW - Ammonia KW - NBCe1 KW - chronic kidney disease KW - glutamine synthetase KW - hepatic encephalopathy KW - lithium SP - 394 EP - 405 JF - Seminars in nephrology JO - Semin. Nephrol. VL - 39 IS - 4 N2 - Ammonia metabolism has a critical role in acid-base homeostasis and in other cellular functions. Kidneys have a central role in bicarbonate generation, which occurs through the process of net acid excretion; ammonia metabolism is the quantitatively greatest component of net acid excretion, both under basal conditions and in response to acid-base disturbances. Several recent studies have advanced our understanding substantially of the molecular mechanisms and regulation of ammonia metabolism. First, the previous paradigm that ammonia transport could be explained by passive NH3 diffusion and NH4+ trapping has been advanced by the recognition that specific transport of NH3 and of NH4+ by specific membrane proteins is critical to ammonia transport. Second, significant advances have been made in the understanding of the regulation of ammonia metabolism. Novel studies have shown that hyperkalemia directly inhibits ammonia metabolism, thereby leading to the metabolic acidosis present in type IV renal tubular acidosis. Other studies have shown that the proximal tubule protein NBCe1, specifically the A variant NBCe1-A, has a major role in regulating renal ammonia metabolism. Third, there are important sex differences in ammonia metabolism that involve structural and functional differences in the kidney. This review addresses these important aspects of ammonia metabolism and transport. SN - 1558-4488 UR - https://www.unboundmedicine.com/medline/citation/31300094/Emerging_Features_of_Ammonia_Metabolism_and_Transport_in_Acid-Base_Balance L2 - https://linkinghub.elsevier.com/retrieve/pii/S0270-9295(19)30041-5 DB - PRIME DP - Unbound Medicine ER -