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Acid Base Balance and Progression of Kidney Disease.
Semin Nephrol 2019; 39(4):406-417SN

Abstract

A large body of work in animals and human beings supports the hypothesis that metabolic acidosis has a deleterious effect on the progression of kidney disease. Alkali therapy, whether pharmacologically or through dietary intervention, appears to slow CKD progression, but an appropriately powered randomized controlled trial with a low risk of bias is required to reach a more definitive conclusion. Recent work on urinary ammonium excretion has shown that the development of prognostic tools related to acidosis is not straightforward, and that application of urine markers such as ammonium may require more nuance than would be predicted based on our understanding of the pathophysiology.

Authors+Show Affiliations

Department of Medicine, Nephrology Division, Albert Einstein College of Medicine, Bronx, NY; Department of Medicine, Nephrology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY. Electronic address: weichen@montefiore.org.Department of Medicine, Nephrology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY.Department of Medicine, Nephrology Division, Albert Einstein College of Medicine, Bronx, NY.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31300095

Citation

Chen, Wei, et al. "Acid Base Balance and Progression of Kidney Disease." Seminars in Nephrology, vol. 39, no. 4, 2019, pp. 406-417.
Chen W, Levy DS, Abramowitz MK. Acid Base Balance and Progression of Kidney Disease. Semin Nephrol. 2019;39(4):406-417.
Chen, W., Levy, D. S., & Abramowitz, M. K. (2019). Acid Base Balance and Progression of Kidney Disease. Seminars in Nephrology, 39(4), pp. 406-417. doi:10.1016/j.semnephrol.2019.04.009.
Chen W, Levy DS, Abramowitz MK. Acid Base Balance and Progression of Kidney Disease. Semin Nephrol. 2019;39(4):406-417. PubMed PMID: 31300095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acid Base Balance and Progression of Kidney Disease. AU - Chen,Wei, AU - Levy,David S, AU - Abramowitz,Matthew K, PY - 2020/07/01/pmc-release PY - 2019/7/14/entrez PY - 2019/7/14/pubmed PY - 2019/7/14/medline KW - Renal insufficiency KW - acidosis KW - alkali therapy KW - alkalosis KW - chronic KW - kidney disease progression SP - 406 EP - 417 JF - Seminars in nephrology JO - Semin. Nephrol. VL - 39 IS - 4 N2 - A large body of work in animals and human beings supports the hypothesis that metabolic acidosis has a deleterious effect on the progression of kidney disease. Alkali therapy, whether pharmacologically or through dietary intervention, appears to slow CKD progression, but an appropriately powered randomized controlled trial with a low risk of bias is required to reach a more definitive conclusion. Recent work on urinary ammonium excretion has shown that the development of prognostic tools related to acidosis is not straightforward, and that application of urine markers such as ammonium may require more nuance than would be predicted based on our understanding of the pathophysiology. SN - 1558-4488 UR - https://www.unboundmedicine.com/medline/citation/31300095/Acid_Base_Balance_and_Progression_of_Kidney_Disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S0270-9295(19)30042-7 DB - PRIME DP - Unbound Medicine ER -