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Sleep and neurological autoimmune diseases.

Abstract

Neurological autoimmune diseases are characterized by an inappropriate immune response that by mistake targets the nervous system. As a result, patients experiment a number of neurological manifestations that may include insomnia, excessive daytime sleepiness, cataplexy, central hypoventilation, and REM sleep behavior disorder. Polysomnographic evaluation may reveal disorganized sleep architecture involving both NREM and REM sleep, and REM sleep intrusions into wakefulness. The study of sleep disorders in the setting of autoimmune diseases (e.g., narcolepsy, anti-IgLON5 disease, paraneoplastic neurological syndromes) shows that an abnormal immune-mediated (humoral or cellular) response target the neuronal structures (e.g., brainstem, hypothalamus) and neurotransmitters systems (e.g., hypocretin) that regulate sleep resulting in sleep impairment. It is a window to examine the link between the autoimmune system and the sleep regulation at the molecular, cellular, and anatomic level.

Authors+Show Affiliations

Neurology Service, Sleep Center, Hospital Clinic de Barcelona, Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain. airanzo@clinic.cat.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31302665

Citation

Iranzo, Alex. "Sleep and Neurological Autoimmune Diseases." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2019.
Iranzo A. Sleep and neurological autoimmune diseases. Neuropsychopharmacology. 2019.
Iranzo, A. (2019). Sleep and neurological autoimmune diseases. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, doi:10.1038/s41386-019-0463-z.
Iranzo A. Sleep and Neurological Autoimmune Diseases. Neuropsychopharmacology. 2019 Jul 14; PubMed PMID: 31302665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep and neurological autoimmune diseases. A1 - Iranzo,Alex, Y1 - 2019/07/14/ PY - 2019/03/03/received PY - 2019/07/02/accepted PY - 2019/06/17/revised PY - 2019/7/16/pubmed PY - 2019/7/16/medline PY - 2019/7/15/entrez JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology N2 - Neurological autoimmune diseases are characterized by an inappropriate immune response that by mistake targets the nervous system. As a result, patients experiment a number of neurological manifestations that may include insomnia, excessive daytime sleepiness, cataplexy, central hypoventilation, and REM sleep behavior disorder. Polysomnographic evaluation may reveal disorganized sleep architecture involving both NREM and REM sleep, and REM sleep intrusions into wakefulness. The study of sleep disorders in the setting of autoimmune diseases (e.g., narcolepsy, anti-IgLON5 disease, paraneoplastic neurological syndromes) shows that an abnormal immune-mediated (humoral or cellular) response target the neuronal structures (e.g., brainstem, hypothalamus) and neurotransmitters systems (e.g., hypocretin) that regulate sleep resulting in sleep impairment. It is a window to examine the link between the autoimmune system and the sleep regulation at the molecular, cellular, and anatomic level. SN - 1740-634X UR - https://www.unboundmedicine.com/medline/citation/31302665/Sleep_and_neurological_autoimmune_diseases L2 - http://dx.doi.org/10.1038/s41386-019-0463-z DB - PRIME DP - Unbound Medicine ER -
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