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Meat intake and risk of hepatocellular carcinoma in two large US prospective cohorts of women and men.
Int J Epidemiol. 2019 12 01; 48(6):1863-1871.IJ

Abstract

BACKGROUND

Epidemiological evidence on the associations between meat intake and risk of hepatocellular carcinoma (HCC) was limited and inconsistent.

METHODS

We prospectively examined the association between consumption of meats and meat mutagens with HCC risk using data from the Nurses' Health Study and the Health Professionals Follow-up Study. Cox proportional-hazards regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for known liver-cancer risk factors.

RESULTS

During up to 32 years of follow-up, we documented 163 incident HCC cases. The HRs of HCC for the highest vs the lowest tertile intake levels were 1.84 (95% CI: 1.16-2.92, Ptrend = 0.04) for processed red meats and 0.61 (95% CI: 0.40-0.91, Ptrend = 0.02) for total white meats. There was a null association between unprocessed red meats and HCC risk (HR = 1.06, 95% CI: 0.68-1.63, Ptrend = 0.85). We found both poultry (HR = 0.60, 95% CI: 0.40-0.90, Ptrend = 0.01) and fish (HR = 0.70, 95% CI: 0.47-1.05, Ptrend = 0.10) were inversely associated with HCC risk. The HR for HCC risk was 0.79 (95% CI: 0.61-1.02) when 1 standard deviation of processed red meats was substituted with an equivalent amount of poultry or fish intake. We also found a suggestive positive association of intake of meat-derived mutagenicity or heterocyclic amines with risk of HCC.

CONCLUSIONS

Processed red meat intake might be associated with higher, whereas poultry or possibly fish intake might be associated with lower, risk of HCC. Replacing processed red meat with poultry or fish might be associated with reduced HCC risk.

Links

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Authors+Show Affiliations

Ma Y
School of Public Health, China Medical University, Shenyang, Liaoning, P. R. China. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Yang W
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Department of Nutrition, School of Public Health, Anhui Medical University, Hefei, Anhui, P.R. China.
Li T
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Liu Y
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Center for Evidence-Based Chinese Medicine, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, P.R. China.
Simon TG
Liver Center, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Clinical and Translational Epidemiology Unit (CTEU), Massachusetts General Hospital, Boston, MA, USA.
Sui J
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, P.R. China.
Wu K
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Giovannucci EL
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Chan AT
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Clinical and Translational Epidemiology Unit (CTEU), Massachusetts General Hospital, Boston, MA, USA.
Zhang X
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

MeSH

AgedAnimalsCarcinoma, HepatocellularDietFemaleFishesFollow-Up StudiesHumansLiver NeoplasmsMaleMiddle AgedPoultryProportional Hazards ModelsProspective StudiesRed MeatRisk AssessmentRisk FactorsUnited States

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31302687

Citation

Ma, Yanan, et al. "Meat Intake and Risk of Hepatocellular Carcinoma in Two Large US Prospective Cohorts of Women and Men." International Journal of Epidemiology, vol. 48, no. 6, 2019, pp. 1863-1871.
Ma Y, Yang W, Li T, et al. Meat intake and risk of hepatocellular carcinoma in two large US prospective cohorts of women and men. Int J Epidemiol. 2019;48(6):1863-1871.
Ma, Y., Yang, W., Li, T., Liu, Y., Simon, T. G., Sui, J., Wu, K., Giovannucci, E. L., Chan, A. T., & Zhang, X. (2019). Meat intake and risk of hepatocellular carcinoma in two large US prospective cohorts of women and men. International Journal of Epidemiology, 48(6), 1863-1871. https://doi.org/10.1093/ije/dyz146
Ma Y, et al. Meat Intake and Risk of Hepatocellular Carcinoma in Two Large US Prospective Cohorts of Women and Men. Int J Epidemiol. 2019 12 1;48(6):1863-1871. PubMed PMID: 31302687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meat intake and risk of hepatocellular carcinoma in two large US prospective cohorts of women and men. AU - Ma,Yanan, AU - Yang,Wanshui, AU - Li,Tricia, AU - Liu,Yue, AU - Simon,Tracey G, AU - Sui,Jing, AU - Wu,Kana, AU - Giovannucci,Edward L, AU - Chan,Andrew T, AU - Zhang,Xuehong, PY - 2019/06/28/accepted PY - 2019/7/16/pubmed PY - 2020/7/16/medline PY - 2019/7/15/entrez KW - Red meat KW - cohort study KW - fish KW - hepatocellular carcinoma KW - poultry KW - processed red meat SP - 1863 EP - 1871 JF - International journal of epidemiology JO - Int J Epidemiol VL - 48 IS - 6 N2 - BACKGROUND: Epidemiological evidence on the associations between meat intake and risk of hepatocellular carcinoma (HCC) was limited and inconsistent. METHODS: We prospectively examined the association between consumption of meats and meat mutagens with HCC risk using data from the Nurses' Health Study and the Health Professionals Follow-up Study. Cox proportional-hazards regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for known liver-cancer risk factors. RESULTS: During up to 32 years of follow-up, we documented 163 incident HCC cases. The HRs of HCC for the highest vs the lowest tertile intake levels were 1.84 (95% CI: 1.16-2.92, Ptrend = 0.04) for processed red meats and 0.61 (95% CI: 0.40-0.91, Ptrend = 0.02) for total white meats. There was a null association between unprocessed red meats and HCC risk (HR = 1.06, 95% CI: 0.68-1.63, Ptrend = 0.85). We found both poultry (HR = 0.60, 95% CI: 0.40-0.90, Ptrend = 0.01) and fish (HR = 0.70, 95% CI: 0.47-1.05, Ptrend = 0.10) were inversely associated with HCC risk. The HR for HCC risk was 0.79 (95% CI: 0.61-1.02) when 1 standard deviation of processed red meats was substituted with an equivalent amount of poultry or fish intake. We also found a suggestive positive association of intake of meat-derived mutagenicity or heterocyclic amines with risk of HCC. CONCLUSIONS: Processed red meat intake might be associated with higher, whereas poultry or possibly fish intake might be associated with lower, risk of HCC. Replacing processed red meat with poultry or fish might be associated with reduced HCC risk. SN - 1464-3685 UR - https://www.unboundmedicine.com/medline/citation/31302687/Meat_intake_and_risk_of_hepatocellular_carcinoma_in_two_large_US_prospective_cohorts_of_women_and_men_ DB - PRIME DP - Unbound Medicine ER -