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Randomized prospective study evaluating addition of corticoid to viscosupplementation: three months of follow-up.
Rev Bras Ortop 2013 Jul-Aug; 48(4):322-329RB

Abstract

Objective

To assess if the initial results of viscosupplementation are improved by the addition of corticosteroid.

Design

We evaluated 104 patients receiving usual care for knee osteoarthritis at the Universidade de São Paulo Medical Center. Patients were randomized to receive either a single intra-articular injection of 6 mL of Hylan GF-20 (Group 1) or a single intra-articular injection of 6 mL of Hylan GF-20 plus 1 mL (20 mg) of Triamcinolone Hexacetonide (Group 2). VAS, WOMAC and Lequesne questionnaires were applied at weeks zero (prior the injection), and after one, four, and 12 weeks.

Results

The baseline measurements of the two groups with 52 patients each were not statistically different. At week one, WOMAC and VAS showed significantly better results for Group 2 compared to Group 1 (p < 0,05). At week four the scores did not show a statistically significant differences. The groups showed similar results at week 12.

Conclusion

The addition of Triamcinolone Hexacetonide improves the short term symptom/functional scores of viscosupplementation.

Authors+Show Affiliations

Postgraduate Student in the Discipline of Orthopedics and Traumatology, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.MSc and PhD in Orthopedics and Traumatology from the School of Medicine, Universidade de São Paulo; Head of the Osteometabolic Diseases Group, Institute of Orthopedics and Traumatology, Hospital das Clínicas, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.Orthopedist in the Department of Orthopedics and Traumatology, Hospital das Clínicas, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.Orthopedist in the Department of Orthopedics and Traumatology, Hospital das Clínicas, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.Orthopedist in the Department of Orthopedics and Traumatology, Hospital das Clínicas, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.Titular Professor of the Department of Orthopedics and Traumatology, Hospital das Clínicas, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31304128

Citation

Campos, Gustavo Constantino de, et al. "Randomized Prospective Study Evaluating Addition of Corticoid to Viscosupplementation: Three Months of Follow-up." Revista Brasileira De Ortopedia, vol. 48, no. 4, 2013, pp. 322-329.
Campos GC, Rezende MU, Pailo AF, et al. Randomized prospective study evaluating addition of corticoid to viscosupplementation: three months of follow-up. Rev Bras Ortop. 2013;48(4):322-329.
Campos, G. C., Rezende, M. U., Pailo, A. F., Frucchi, R., Pasqualim, T., & Camargo, O. P. (2013). Randomized prospective study evaluating addition of corticoid to viscosupplementation: three months of follow-up. Revista Brasileira De Ortopedia, 48(4), pp. 322-329. doi:10.1016/j.rboe.2012.08.005.
Campos GC, et al. Randomized Prospective Study Evaluating Addition of Corticoid to Viscosupplementation: Three Months of Follow-up. Rev Bras Ortop. 2013;48(4):322-329. PubMed PMID: 31304128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized prospective study evaluating addition of corticoid to viscosupplementation: three months of follow-up. AU - Campos,Gustavo Constantino de, AU - Rezende,Márcia Uchôa de, AU - Pailo,Alexandre Felício, AU - Frucchi,Renato, AU - Pasqualim,Thiago, AU - Camargo,Olavo Pires de, Y1 - 2013/09/27/ PY - 2012/06/28/received PY - 2012/08/03/accepted PY - 2019/7/16/entrez PY - 2013/9/27/pubmed PY - 2013/9/27/medline KW - Adrenal cortex hormones Clinical trial KW - Controlled clinical trial Double-blind method Hyaluronic acid Injections KW - Pain measurement Treatment outcome Viscosupplementation KW - intra-articular Osteoarthritis KW - knee SP - 322 EP - 329 JF - Revista brasileira de ortopedia JO - Rev Bras Ortop VL - 48 IS - 4 N2 - Objective: To assess if the initial results of viscosupplementation are improved by the addition of corticosteroid. Design: We evaluated 104 patients receiving usual care for knee osteoarthritis at the Universidade de São Paulo Medical Center. Patients were randomized to receive either a single intra-articular injection of 6 mL of Hylan GF-20 (Group 1) or a single intra-articular injection of 6 mL of Hylan GF-20 plus 1 mL (20 mg) of Triamcinolone Hexacetonide (Group 2). VAS, WOMAC and Lequesne questionnaires were applied at weeks zero (prior the injection), and after one, four, and 12 weeks. Results: The baseline measurements of the two groups with 52 patients each were not statistically different. At week one, WOMAC and VAS showed significantly better results for Group 2 compared to Group 1 (p < 0,05). At week four the scores did not show a statistically significant differences. The groups showed similar results at week 12. Conclusion: The addition of Triamcinolone Hexacetonide improves the short term symptom/functional scores of viscosupplementation. SN - 2255-4971 UR - https://www.unboundmedicine.com/medline/citation/31304128/Randomized_prospective_study_evaluating_addition_of_corticoid_to_viscosupplementation:_three_months_of_follow-up L2 - https://linkinghub.elsevier.com/retrieve/pii/S2255-4971(13)00078-5 DB - PRIME DP - Unbound Medicine ER -